Single cell type - CLASP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLASP2
Gene descriptionⁱ Full gene name according to HGNC.	Cytoplasmic linker associated protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CLASP2 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NALCN	Sodium leak channel, non-selective	0.9026	42
DNM3	Dynamin 3	0.8505	42
SPDYE11	Speedy/RINGO cell cycle regulator family member E11	0.8073	42
CADM2	Cell adhesion molecule 2	0.8071	42
LRRC8D	Leucine rich repeat containing 8 VRAC subunit D	0.7842	42
FRMD5	FERM domain containing 5	0.7831	42
TMED7-TICAM2	TMED7-TICAM2 readthrough	0.7742	42
KLHL32	Kelch like family member 32	0.7730	42
EDIL3	EGF like repeats and discoidin domains 3	0.7695	42
DIP2C	Disco interacting protein 2 homolog C	0.7692	42
NHLH1	Nescient helix-loop-helix 1	0.7579	42
GAB2	GRB2 associated binding protein 2	0.7472	42
DTNB	Dystrobrevin beta	0.7458	42
PTH	Parathyroid hormone	0.7396	42
DLG2	Discs large MAGUK scaffold protein 2	0.7342	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.7 nTPM
Adipose tissue	24.4 nTPM
Breast	14.9 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	11.7 nTPM
Lung	11.7 nTPM

B-cells	29.9 nTPM
Spleen	48.2 nTPM
Stomach	48.1 nTPM
Lymph node	42.7 nTPM
Adipose tissue	40.1 nTPM
Bone marrow	36.8 nTPM
Colon	25.5 nTPM
Breast	24.1 nTPM
PBMC	17.1 nTPM
Liver	11.8 nTPM
Kidney	4.8 nTPM

Basal keratinocytes	21.0 nTPM
Skin	21.0 nTPM

Dendritic cells	36.2 nTPM
PBMC	51.8 nTPM
Adipose tissue	36.2 nTPM
Breast	20.7 nTPM

Endothelial cells	16.1 nTPM
Heart muscle	35.7 nTPM
Skeletal muscle	23.2 nTPM
Esophagus	23.1 nTPM
Endometrium	19.4 nTPM
Skin	18.5 nTPM
Ovary	18.3 nTPM
Breast	17.7 nTPM
Prostate	14.1 nTPM
Placenta	13.1 nTPM
Liver	12.8 nTPM
Testis	12.5 nTPM
Eye	11.3 nTPM
Lung	6.2 nTPM
Pancreas	0.0 nTPM

Fibroblasts	19.2 nTPM
Esophagus	33.7 nTPM
Stomach	32.7 nTPM
Skin	23.1 nTPM
Skeletal muscle	21.4 nTPM
Lung	19.0 nTPM
Adipose tissue	17.2 nTPM
Breast	16.5 nTPM
Ovary	14.9 nTPM
Heart muscle	13.5 nTPM
Prostate	13.1 nTPM
Placenta	6.5 nTPM

Intestinal goblet cells	8.8 nTPM
Rectum	11.3 nTPM
Small intestine	9.4 nTPM
Colon	5.8 nTPM

Macrophages	26.0 nTPM
Esophagus	59.8 nTPM
Spleen	41.4 nTPM
Adipose tissue	36.7 nTPM
Stomach	35.1 nTPM
Skeletal muscle	29.8 nTPM
Ovary	27.9 nTPM
Endometrium	26.3 nTPM
Bone marrow	26.2 nTPM
Kidney	21.1 nTPM
Breast	20.0 nTPM
Prostate	19.5 nTPM
Lung	18.3 nTPM
Testis	17.4 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	5.6 nTPM
Rectum	9.2 nTPM
Small intestine	7.5 nTPM
Colon	0.0 nTPM

Plasma cells	28.8 nTPM
Adipose tissue	49.7 nTPM
Spleen	30.2 nTPM
Bone marrow	29.7 nTPM
Stomach	28.3 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	13.8 nTPM
Bronchus	17.3 nTPM
Lung	10.2 nTPM

Smooth muscle cells	22.9 nTPM
Esophagus	43.4 nTPM
Heart muscle	33.1 nTPM
Endometrium	30.1 nTPM
Skeletal muscle	28.1 nTPM
Adipose tissue	25.6 nTPM
Breast	22.1 nTPM
Prostate	21.3 nTPM
Skin	20.2 nTPM
Ovary	12.2 nTPM
Pancreas	9.8 nTPM
Bronchus	5.7 nTPM

T-cells	25.6 nTPM
Esophagus	45.9 nTPM
Skeletal muscle	35.3 nTPM
Stomach	35.3 nTPM
Skin	34.0 nTPM
Spleen	32.7 nTPM
Adipose tissue	32.0 nTPM
Bone marrow	32.0 nTPM
Endometrium	30.6 nTPM
Lymph node	29.7 nTPM
Breast	25.7 nTPM
Liver	20.4 nTPM
PBMC	19.3 nTPM
Colon	18.5 nTPM
Ovary	13.4 nTPM
Kidney	13.1 nTPM
Prostate	9.5 nTPM
Lung	7.6 nTPM

Astrocytes	294.5 nTPM
Brain	294.5 nTPM

Cholangiocytes	15.7 nTPM
Liver	15.7 nTPM

Collecting duct cells	14.7 nTPM
Kidney	14.7 nTPM

Cone photoreceptor cells	156.4 nTPM
Eye	156.4 nTPM

Undifferentiated cells	11.2 nTPM
Rectum	12.2 nTPM
Small intestine	11.6 nTPM
Colon	9.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC