Single cell type - PPM1K - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPM1K
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase, Mg2+/Mn2+ dependent 1K
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, Karpas-707, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PPM1K is part of cluster 54 Cardiomyocytes - Muscle contraction with confidenceⁱ 1
250 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NEBL	Nebulette	0.5852	54
MT-ATP8	Mitochondrially encoded ATP synthase membrane subunit 8	0.5790	54
TMEM182	Transmembrane protein 182	0.5709	54
POPDC2	Popeye domain containing 2	0.5657	54
FLNC	Filamin C	0.5580	54
MYH7	Myosin heavy chain 7	0.5577	54
MT-ND6	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	0.5556	54
HSPB7	Heat shock protein family B (small) member 7	0.5542	54
FBXO40	F-box protein 40	0.5519	54
MYBPC3	Myosin binding protein C3	0.5513	54
COX7A1	Cytochrome c oxidase subunit 7A1	0.5498	54
GPR22	G protein-coupled receptor 22	0.5497	8
NMRK2	Nicotinamide riboside kinase 2	0.5461	54
MT-ND4L	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L	0.5431	54
CKMT2	Creatine kinase, mitochondrial 2	0.5427	54

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.7 nTPM
Breast	22.6 nTPM
Adipose tissue	18.7 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	12.4 nTPM
Lung	12.4 nTPM

Astrocytes	105.4 nTPM
Brain	105.4 nTPM

B-cells	124.8 nTPM
PBMC	192.7 nTPM
Lymph node	172.8 nTPM
Colon	137.4 nTPM
Adipose tissue	131.8 nTPM
Bone marrow	117.7 nTPM
Spleen	106.9 nTPM
Stomach	106.7 nTPM
Breast	100.3 nTPM
Liver	95.7 nTPM
Kidney	85.7 nTPM

Dendritic cells	153.0 nTPM
PBMC	290.9 nTPM
Breast	93.7 nTPM
Adipose tissue	74.5 nTPM

Endothelial cells	27.2 nTPM
Heart muscle	91.5 nTPM
Eye	43.7 nTPM
Prostate	36.5 nTPM
Skin	31.7 nTPM
Skeletal muscle	27.5 nTPM
Breast	23.7 nTPM
Endometrium	20.9 nTPM
Ovary	19.1 nTPM
Esophagus	17.5 nTPM
Liver	16.5 nTPM
Testis	16.0 nTPM
Lung	15.6 nTPM
Placenta	12.5 nTPM
Pancreas	7.7 nTPM

Fibroblasts	42.9 nTPM
Heart muscle	122.5 nTPM
Esophagus	58.0 nTPM
Prostate	55.7 nTPM
Lung	44.6 nTPM
Ovary	35.3 nTPM
Breast	31.0 nTPM
Placenta	29.4 nTPM
Skeletal muscle	27.9 nTPM
Stomach	26.7 nTPM
Skin	26.2 nTPM
Adipose tissue	14.9 nTPM

Intestinal goblet cells	16.5 nTPM
Colon	22.1 nTPM
Small intestine	14.0 nTPM
Rectum	13.4 nTPM

Macrophages	27.5 nTPM
Ovary	58.2 nTPM
Breast	49.2 nTPM
Endometrium	41.0 nTPM
Esophagus	33.1 nTPM
Testis	29.7 nTPM
Spleen	27.9 nTPM
PBMC	27.3 nTPM
Prostate	26.3 nTPM
Skeletal muscle	24.7 nTPM
Lung	24.4 nTPM
Adipose tissue	23.5 nTPM
Bone marrow	21.2 nTPM
Kidney	13.7 nTPM
Pancreas	12.8 nTPM
Stomach	0.0 nTPM

Paneth cells	9.2 nTPM
Small intestine	18.8 nTPM
Rectum	5.5 nTPM
Colon	3.3 nTPM

Plasma cells	82.7 nTPM
Esophagus	135.4 nTPM
Stomach	99.3 nTPM
Adipose tissue	62.5 nTPM
Bone marrow	59.4 nTPM
Spleen	57.1 nTPM

Respiratory ciliated cells	19.5 nTPM
Lung	26.2 nTPM
Bronchus	12.8 nTPM

Smooth muscle cells	36.4 nTPM
Endometrium	72.3 nTPM
Heart muscle	62.9 nTPM
Prostate	46.5 nTPM
Skeletal muscle	44.5 nTPM
Skin	40.1 nTPM
Esophagus	34.1 nTPM
Breast	30.7 nTPM
Adipose tissue	27.6 nTPM
Ovary	26.9 nTPM
Pancreas	13.2 nTPM
Bronchus	1.9 nTPM

T-cells	70.1 nTPM
Breast	113.1 nTPM
Lymph node	103.2 nTPM
PBMC	86.2 nTPM
Spleen	82.9 nTPM
Skeletal muscle	76.6 nTPM
Adipose tissue	75.3 nTPM
Stomach	73.3 nTPM
Liver	72.3 nTPM
Colon	62.7 nTPM
Bone marrow	62.0 nTPM
Prostate	61.6 nTPM
Kidney	58.9 nTPM
Esophagus	58.9 nTPM
Ovary	57.8 nTPM
Skin	54.7 nTPM
Lung	51.6 nTPM
Endometrium	41.0 nTPM

Basal keratinocytes	9.8 nTPM
Skin	9.8 nTPM

Basal prostatic cells	15.8 nTPM
Prostate	15.8 nTPM

Basal respiratory cells	5.7 nTPM
Bronchus	5.7 nTPM

Basal squamous epithelial cells	29.6 nTPM
Esophagus	29.6 nTPM

Undifferentiated cells	4.1 nTPM
Small intestine	7.8 nTPM
Colon	2.3 nTPM
Rectum	2.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC