Single cell type - TIPARP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TIPARP
Gene descriptionⁱ Full gene name according to HGNC.	TCDD inducible poly(ADP-ribose) polymerase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HBEC3-KT)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TIPARP is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ABCF2-H2BE1	ABCF2-H2BE1 readthrough	0.7151	24
JUND	JunD proto-oncogene, AP-1 transcription factor subunit	0.7148	7
NPIPA9	Nuclear pore complex interacting protein family, member A9	0.6929	50
MRTFA	Myocardin related transcription factor A	0.6691	24
KLF6	Kruppel like factor 6	0.6676	7
PER1	Period circadian regulator 1	0.6613	24
ZFP36	ZFP36 ring finger protein	0.6571	50
NOTCH2NLA	Notch 2 N-terminal like A	0.6336	41
H1-10	H1.10 linker histone	0.6238	24
ATF7-NPFF	ATF7-NPFF readthrough	0.6170	24
KRTAP13-4	Keratin associated protein 13-4	0.6117	50
PRXL2C	Peroxiredoxin like 2C	0.6082	24
STRIT1	Small transmembrane regulator of ion transport 1	0.6027	50
FOS	Fos proto-oncogene, AP-1 transcription factor subunit	0.6012	50
TMDD1	Transmembrane and death domain 1	0.5927	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	112.8 nTPM
Adipose tissue	191.1 nTPM
Breast	34.5 nTPM

Alveolar cells type 1	86.6 nTPM
Lung	86.6 nTPM

Alveolar cells type 2	98.3 nTPM
Lung	98.3 nTPM

Astrocytes	27.7 nTPM
Brain	27.7 nTPM

B-cells	43.9 nTPM
Adipose tissue	128.8 nTPM
Breast	74.9 nTPM
Stomach	59.0 nTPM
Spleen	52.2 nTPM
Colon	51.1 nTPM
Lymph node	45.9 nTPM
Bone marrow	9.8 nTPM
Liver	8.0 nTPM
Kidney	4.8 nTPM
PBMC	4.3 nTPM

Basal squamous epithelial cells	185.5 nTPM
Esophagus	185.5 nTPM

Dendritic cells	97.0 nTPM
Adipose tissue	178.9 nTPM
Breast	96.2 nTPM
PBMC	16.0 nTPM

Endothelial cells	45.6 nTPM
Prostate	132.8 nTPM
Endometrium	91.7 nTPM
Skin	77.8 nTPM
Skeletal muscle	68.7 nTPM
Eye	65.5 nTPM
Esophagus	55.8 nTPM
Lung	37.4 nTPM
Breast	27.6 nTPM
Liver	19.2 nTPM
Heart muscle	17.6 nTPM
Pancreas	15.5 nTPM
Ovary	12.4 nTPM
Testis	11.6 nTPM
Placenta	4.6 nTPM

Fibroblasts	109.0 nTPM
Adipose tissue	509.4 nTPM
Prostate	211.7 nTPM
Skeletal muscle	117.9 nTPM
Skin	82.2 nTPM
Lung	75.9 nTPM
Stomach	60.9 nTPM
Esophagus	56.3 nTPM
Heart muscle	38.0 nTPM
Breast	24.3 nTPM
Placenta	15.6 nTPM
Ovary	6.8 nTPM

Intestinal goblet cells	32.4 nTPM
Colon	52.1 nTPM
Small intestine	24.1 nTPM
Rectum	21.0 nTPM

Macrophages	101.7 nTPM
Adipose tissue	538.6 nTPM
Endometrium	180.4 nTPM
Skeletal muscle	166.7 nTPM
Breast	154.1 nTPM
Esophagus	103.9 nTPM
Spleen	76.7 nTPM
Stomach	73.3 nTPM
Ovary	62.5 nTPM
Prostate	57.3 nTPM
Lung	42.1 nTPM
Testis	20.3 nTPM
Bone marrow	18.8 nTPM
Pancreas	17.8 nTPM
Kidney	12.9 nTPM
PBMC	0.0 nTPM

Paneth cells	40.1 nTPM
Colon	69.2 nTPM
Small intestine	30.0 nTPM
Rectum	21.0 nTPM

Plasma cells	60.5 nTPM
Adipose tissue	130.9 nTPM
Stomach	76.4 nTPM
Esophagus	74.0 nTPM
Spleen	16.3 nTPM
Bone marrow	5.0 nTPM

Respiratory ciliated cells	43.5 nTPM
Lung	51.0 nTPM
Bronchus	36.0 nTPM

Smooth muscle cells	87.7 nTPM
Adipose tissue	247.0 nTPM
Prostate	164.7 nTPM
Skin	136.7 nTPM
Bronchus	114.4 nTPM
Skeletal muscle	110.3 nTPM
Endometrium	59.0 nTPM
Breast	46.1 nTPM
Esophagus	32.5 nTPM
Ovary	29.3 nTPM
Heart muscle	16.5 nTPM
Pancreas	8.2 nTPM

Cholangiocytes	31.5 nTPM
Liver	31.5 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cone photoreceptor cells	39.6 nTPM
Eye	39.6 nTPM

Cytotrophoblasts	5.1 nTPM
Placenta	5.1 nTPM

T-cells	105.4 nTPM
Adipose tissue	342.4 nTPM
Breast	207.9 nTPM
Endometrium	192.3 nTPM
Skin	169.5 nTPM
Colon	158.2 nTPM
Skeletal muscle	113.2 nTPM
Stomach	102.8 nTPM
Esophagus	98.3 nTPM
Spleen	96.2 nTPM
Ovary	82.3 nTPM
Prostate	80.4 nTPM
Lymph node	46.0 nTPM
Lung	36.5 nTPM
Liver	24.9 nTPM
Bone marrow	17.3 nTPM
Kidney	13.1 nTPM
PBMC	9.9 nTPM

Undifferentiated cells	18.2 nTPM
Colon	29.7 nTPM
Rectum	13.0 nTPM
Small intestine	12.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC