Single cell type - MEAF6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MEAF6
Gene descriptionⁱ Full gene name according to HGNC.	MYST/Esa1 associated factor 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Glandular cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MEAF6 is part of cluster 35 Glandular cells - Unknown function with confidenceⁱ 1
101 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TRMT112	TRNA methyltransferase subunit 11-2	0.6148	39
GOLGA7	Golgin A7	0.5469	39
RLN1	Relaxin 1	0.5192	35
POLR2K	RNA polymerase II, I and III subunit K	0.5101	39
MED31	Mediator complex subunit 31	0.5083	49
TSPYL1	TSPY like 1	0.4979	67
EDDM3B	Epididymal protein 3B	0.4841	35
TSTD1	Thiosulfate sulfurtransferase like domain containing 1	0.4837	53
PYURF	PIGY upstream reading frame	0.4822	32
C2orf76	Chromosome 2 open reading frame 76	0.4819	39
COA5	Cytochrome c oxidase assembly factor 5	0.4787	39
MRPS6	Mitochondrial ribosomal protein S6	0.4707	22
HSD11B1L	Hydroxysteroid 11-beta dehydrogenase 1 like	0.4658	49
ELOVL5	ELOVL fatty acid elongase 5	0.4656	35
TMEM50B	Transmembrane protein 50B	0.4622	13

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	71.4 nTPM
Breast	85.5 nTPM
Adipose tissue	57.4 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	47.2 nTPM
Lung	47.2 nTPM

Astrocytes	30.0 nTPM
Brain	30.0 nTPM

B-cells	102.9 nTPM
Kidney	171.4 nTPM
Bone marrow	127.6 nTPM
PBMC	124.2 nTPM
Stomach	116.7 nTPM
Spleen	111.1 nTPM
Lymph node	103.1 nTPM
Colon	83.1 nTPM
Breast	77.5 nTPM
Liver	57.5 nTPM
Adipose tissue	57.2 nTPM

Dendritic cells	94.0 nTPM
Breast	108.6 nTPM
Adipose tissue	93.5 nTPM
PBMC	79.7 nTPM

Endothelial cells	59.4 nTPM
Skin	100.9 nTPM
Breast	89.0 nTPM
Liver	88.1 nTPM
Placenta	63.6 nTPM
Esophagus	61.4 nTPM
Ovary	59.0 nTPM
Testis	55.1 nTPM
Prostate	51.0 nTPM
Pancreas	50.2 nTPM
Skeletal muscle	50.0 nTPM
Eye	49.3 nTPM
Endometrium	38.5 nTPM
Heart muscle	38.1 nTPM
Lung	37.4 nTPM

Fibroblasts	74.2 nTPM
Skin	122.1 nTPM
Breast	90.7 nTPM
Adipose tissue	82.4 nTPM
Esophagus	81.4 nTPM
Stomach	75.7 nTPM
Prostate	73.0 nTPM
Placenta	70.4 nTPM
Ovary	67.4 nTPM
Lung	65.9 nTPM
Skeletal muscle	49.6 nTPM
Heart muscle	37.7 nTPM

Intestinal goblet cells	60.3 nTPM
Small intestine	80.8 nTPM
Rectum	56.4 nTPM
Colon	43.6 nTPM

Macrophages	61.5 nTPM
Kidney	103.7 nTPM
Testis	84.8 nTPM
Ovary	79.1 nTPM
Bone marrow	76.2 nTPM
Breast	75.2 nTPM
Prostate	64.2 nTPM
Pancreas	63.8 nTPM
Spleen	61.1 nTPM
Adipose tissue	56.9 nTPM
Stomach	52.7 nTPM
Esophagus	48.7 nTPM
Endometrium	47.5 nTPM
Lung	42.5 nTPM
Skeletal muscle	38.5 nTPM
PBMC	27.3 nTPM

Paneth cells	35.8 nTPM
Small intestine	56.3 nTPM
Rectum	41.3 nTPM
Colon	9.9 nTPM

Plasma cells	59.4 nTPM
Stomach	78.0 nTPM
Esophagus	61.7 nTPM
Bone marrow	61.0 nTPM
Spleen	59.2 nTPM
Adipose tissue	37.4 nTPM

Respiratory ciliated cells	174.7 nTPM
Bronchus	212.5 nTPM
Lung	137.0 nTPM

Smooth muscle cells	79.2 nTPM
Esophagus	103.9 nTPM
Skin	101.1 nTPM
Ovary	94.3 nTPM
Bronchus	89.9 nTPM
Breast	88.3 nTPM
Prostate	77.3 nTPM
Heart muscle	74.4 nTPM
Pancreas	71.3 nTPM
Skeletal muscle	65.2 nTPM
Adipose tissue	56.8 nTPM
Endometrium	49.3 nTPM

T-cells	111.6 nTPM
Skin	180.9 nTPM
Kidney	162.2 nTPM
Ovary	135.6 nTPM
Colon	126.4 nTPM
PBMC	122.9 nTPM
Stomach	122.9 nTPM
Bone marrow	120.0 nTPM
Spleen	119.3 nTPM
Liver	117.2 nTPM
Lymph node	110.0 nTPM
Breast	105.8 nTPM
Prostate	104.2 nTPM
Adipose tissue	99.3 nTPM
Skeletal muscle	92.8 nTPM
Endometrium	61.7 nTPM
Esophagus	58.9 nTPM
Lung	56.2 nTPM

Basal keratinocytes	211.8 nTPM
Skin	211.8 nTPM

Basal prostatic cells	179.3 nTPM
Prostate	179.3 nTPM

Basal respiratory cells	158.5 nTPM
Bronchus	158.5 nTPM

Basal squamous epithelial cells	84.2 nTPM
Esophagus	84.2 nTPM

Undifferentiated cells	52.3 nTPM
Small intestine	69.6 nTPM
Colon	45.0 nTPM
Rectum	42.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC