Single cell type - METAP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	METAP1
Gene descriptionⁱ Full gene name according to HGNC.	Methionyl aminopeptidase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

METAP1 is part of cluster 25 Spermatids - Spermatogenesis with confidenceⁱ 1
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LELP1	Late cornified envelope like proline rich 1	0.9368	25
UBL4B	Ubiquitin like 4B	0.9319	25
NUP35	Nucleoporin 35	0.9314	25
BOD1L2	Biorientation of chromosomes in cell division 1 like 2	0.9306	25
DCUN1D1	Defective in cullin neddylation 1 domain containing 1	0.9278	25
SMCP	Sperm mitochondria associated cysteine rich protein	0.9253	25
TEX38	Testis expressed 38	0.9253	25
ABHD1	Abhydrolase domain containing 1	0.9253	25
ODF3L2	Outer dense fiber of sperm tails 3 like 2	0.9228	25
CCDC91	Coiled-coil domain containing 91	0.9177	25
NUPR2	Nuclear protein 2, transcriptional regulator	0.9175	25
UBQLN3	Ubiquilin 3	0.9138	25
UBQLNL	Ubiquilin like	0.9136	25
PROCA1	Protein interacting with cyclin A1	0.9133	25
OAZ3	Ornithine decarboxylase antizyme 3	0.9131	25

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.1 nTPM
Adipose tissue	17.1 nTPM
Breast	15.2 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	14.6 nTPM
Lung	14.6 nTPM

Astrocytes	20.2 nTPM
Brain	20.2 nTPM

B-cells	19.8 nTPM
Lymph node	32.3 nTPM
Spleen	31.1 nTPM
Bone marrow	24.5 nTPM
Liver	24.3 nTPM
Adipose tissue	18.6 nTPM
Stomach	18.6 nTPM
Kidney	14.3 nTPM
PBMC	14.3 nTPM
Breast	10.7 nTPM
Colon	9.6 nTPM

Dendritic cells	17.4 nTPM
Adipose tissue	27.6 nTPM
Breast	20.7 nTPM
PBMC	4.0 nTPM

Endothelial cells	17.3 nTPM
Heart muscle	39.2 nTPM
Endometrium	22.2 nTPM
Skin	20.4 nTPM
Testis	20.1 nTPM
Prostate	18.9 nTPM
Ovary	18.4 nTPM
Breast	18.1 nTPM
Esophagus	17.0 nTPM
Liver	13.7 nTPM
Placenta	13.7 nTPM
Skeletal muscle	11.8 nTPM
Pancreas	11.6 nTPM
Lung	9.3 nTPM
Eye	8.1 nTPM

Fibroblasts	15.3 nTPM
Heart muscle	22.7 nTPM
Ovary	19.9 nTPM
Lung	17.9 nTPM
Prostate	17.3 nTPM
Esophagus	15.2 nTPM
Breast	14.5 nTPM
Placenta	14.0 nTPM
Stomach	13.4 nTPM
Skin	12.4 nTPM
Adipose tissue	11.9 nTPM
Skeletal muscle	9.0 nTPM

Intestinal goblet cells	23.3 nTPM
Rectum	35.0 nTPM
Small intestine	19.8 nTPM
Colon	15.0 nTPM

Macrophages	17.4 nTPM
Testis	30.8 nTPM
Endometrium	21.2 nTPM
Bone marrow	21.2 nTPM
Adipose tissue	19.9 nTPM
Lung	19.8 nTPM
Esophagus	18.9 nTPM
Spleen	18.6 nTPM
Skeletal muscle	17.7 nTPM
Stomach	17.6 nTPM
Ovary	17.1 nTPM
Kidney	15.8 nTPM
Breast	14.9 nTPM
Prostate	13.8 nTPM
PBMC	13.6 nTPM
Pancreas	0.0 nTPM

Paneth cells	30.8 nTPM
Small intestine	41.3 nTPM
Rectum	37.8 nTPM
Colon	13.2 nTPM

Plasma cells	17.8 nTPM
Spleen	33.8 nTPM
Stomach	15.0 nTPM
Adipose tissue	14.9 nTPM
Bone marrow	13.2 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	17.2 nTPM
Lung	20.4 nTPM
Bronchus	14.1 nTPM

Smooth muscle cells	21.7 nTPM
Heart muscle	44.1 nTPM
Pancreas	32.6 nTPM
Bronchus	31.9 nTPM
Endometrium	22.9 nTPM
Skin	22.0 nTPM
Esophagus	17.0 nTPM
Ovary	16.8 nTPM
Prostate	15.0 nTPM
Breast	14.8 nTPM
Adipose tissue	12.2 nTPM
Skeletal muscle	9.2 nTPM

T-cells	23.6 nTPM
Lymph node	36.5 nTPM
Spleen	32.8 nTPM
Adipose tissue	31.7 nTPM
Bone marrow	31.4 nTPM
Ovary	31.1 nTPM
Skin	27.1 nTPM
Endometrium	25.6 nTPM
Liver	24.4 nTPM
Stomach	22.5 nTPM
Lung	21.3 nTPM
PBMC	21.0 nTPM
Skeletal muscle	20.9 nTPM
Breast	18.8 nTPM
Kidney	14.4 nTPM
Prostate	14.2 nTPM
Colon	13.8 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	42.4 nTPM
Skin	42.4 nTPM

Basal prostatic cells	47.5 nTPM
Prostate	47.5 nTPM

Basal respiratory cells	26.2 nTPM
Bronchus	26.2 nTPM

Basal squamous epithelial cells	51.2 nTPM
Esophagus	51.2 nTPM

Undifferentiated cells	36.2 nTPM
Rectum	37.3 nTPM
Small intestine	36.9 nTPM
Colon	34.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC