Single cell type - TMEM144 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM144
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 144
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (plasmacytoid DC, myeloid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BEWO)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM144 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LRRC63	Leucine rich repeat containing 63	0.8352	42
MOBP	Myelin associated oligodendrocyte basic protein	0.8319	42
CTNNA3	Catenin alpha 3	0.8016	42
OR9A2	Olfactory receptor family 9 subfamily A member 2	0.7893	42
SLC5A11	Solute carrier family 5 member 11	0.7876	42
CNTN2	Contactin 2	0.7664	42
RNF220	Ring finger protein 220	0.7663	42
OPALIN	Oligodendrocytic myelin paranodal and inner loop protein	0.7645	42
TRPV5	Transient receptor potential cation channel subfamily V member 5	0.7641	42
ERMN	Ermin	0.7591	42
MOG	Myelin oligodendrocyte glycoprotein	0.7587	42
MAN2A1	Mannosidase alpha class 2A member 1	0.7572	42
TMEM235	Transmembrane protein 235	0.7562	42
ST18	ST18 C2H2C-type zinc finger transcription factor	0.7457	42
SLCO1A2	Solute carrier organic anion transporter family member 1A2	0.7366	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.9 nTPM
Breast	3.5 nTPM
Adipose tissue	2.2 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	9.1 nTPM
Lung	9.1 nTPM

Astrocytes	53.2 nTPM
Brain	53.2 nTPM

B-cells	0.3 nTPM
Liver	1.3 nTPM
Bone marrow	0.8 nTPM
Stomach	0.5 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	1.5 nTPM
PBMC	4.0 nTPM
Breast	0.4 nTPM
Adipose tissue	0.1 nTPM

Endothelial cells	4.8 nTPM
Heart muscle	14.4 nTPM
Testis	11.6 nTPM
Skeletal muscle	5.7 nTPM
Liver	5.5 nTPM
Endometrium	5.2 nTPM
Skin	4.6 nTPM
Pancreas	3.9 nTPM
Ovary	3.5 nTPM
Breast	3.5 nTPM
Prostate	3.1 nTPM
Placenta	2.9 nTPM
Esophagus	2.1 nTPM
Eye	1.6 nTPM
Lung	0.0 nTPM

Fibroblasts	4.4 nTPM
Breast	12.4 nTPM
Heart muscle	12.2 nTPM
Skeletal muscle	6.2 nTPM
Esophagus	5.0 nTPM
Ovary	4.2 nTPM
Adipose tissue	2.5 nTPM
Prostate	2.4 nTPM
Skin	2.4 nTPM
Placenta	1.5 nTPM
Lung	0.0 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	21.4 nTPM
Small intestine	24.5 nTPM
Rectum	21.7 nTPM
Colon	17.9 nTPM

Macrophages	12.9 nTPM
Ovary	31.4 nTPM
Prostate	20.7 nTPM
Breast	16.3 nTPM
Kidney	15.8 nTPM
Pancreas	15.3 nTPM
Esophagus	14.2 nTPM
Testis	14.0 nTPM
Spleen	11.4 nTPM
Endometrium	10.9 nTPM
Skeletal muscle	10.5 nTPM
Stomach	8.8 nTPM
Bone marrow	8.7 nTPM
Adipose tissue	7.9 nTPM
Lung	7.6 nTPM
PBMC	0.0 nTPM

Paneth cells	18.9 nTPM
Colon	32.9 nTPM
Rectum	16.2 nTPM
Small intestine	7.5 nTPM

Plasma cells	0.2 nTPM
Adipose tissue	0.6 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	8.8 nTPM
Bronchus	11.8 nTPM
Lung	5.8 nTPM

Smooth muscle cells	2.6 nTPM
Heart muscle	6.6 nTPM
Ovary	6.3 nTPM
Breast	2.9 nTPM
Endometrium	2.7 nTPM
Pancreas	2.6 nTPM
Skin	2.4 nTPM
Bronchus	1.9 nTPM
Prostate	1.5 nTPM
Adipose tissue	1.1 nTPM
Skeletal muscle	0.2 nTPM
Esophagus	0.0 nTPM

T-cells	0.9 nTPM
Prostate	9.5 nTPM
Endometrium	2.8 nTPM
Breast	0.6 nTPM
Colon	0.5 nTPM
Skin	0.5 nTPM
Skeletal muscle	0.5 nTPM
PBMC	0.1 nTPM
Stomach	0.1 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Lung	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Basal prostatic cells	7.7 nTPM
Prostate	7.7 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Cytotrophoblasts	13.7 nTPM
Placenta	13.7 nTPM

Distal enterocytes	36.6 nTPM
Rectum	48.5 nTPM
Colon	24.7 nTPM

Undifferentiated cells	18.6 nTPM
Small intestine	22.9 nTPM
Rectum	17.1 nTPM
Colon	15.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC