Single cell type - FABP5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FABP5
Gene descriptionⁱ Full gene name according to HGNC.	Fatty acid binding protein 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Squamous epithelial cells, Adipocytes, Hofbauer cells, Alveolar cells type 2)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, MOLT-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Squamous epithelial cells, Adipocytes, Hofbauer cells, Alveolar cells type 2)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FABP5 is part of cluster 61 Squamous epithelial cells - Keratinization with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SPINK5	Serine peptidase inhibitor Kazal type 5	0.8391	61
GBP6	Guanylate binding protein family member 6	0.8380	61
UGT1A7	UDP glucuronosyltransferase family 1 member A7	0.8359	61
KRT6C	Keratin 6C	0.8323	61
KRT13	Keratin 13	0.8314	61
CALML3	Calmodulin like 3	0.8288	61
KRT4	Keratin 4	0.8278	61
RHCG	Rh family C glycoprotein	0.8275	61
PGLYRP3	Peptidoglycan recognition protein 3	0.8248	61
SPINK7	Serine peptidase inhibitor Kazal type 7	0.8237	61
CRNN	Cornulin	0.8232	61
MC5R	Melanocortin 5 receptor	0.8217	61
DSG3	Desmoglein 3	0.8201	61
NMU	Neuromedin U	0.8188	61
PITX1	Paired like homeodomain 1	0.8184	61

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	288.4 nTPM
Lung	288.4 nTPM

Astrocytes	30.7 nTPM
Brain	30.7 nTPM

B-cells	93.0 nTPM
Liver	238.8 nTPM
Breast	141.8 nTPM
Colon	111.8 nTPM
Spleen	106.9 nTPM
Lymph node	90.3 nTPM
Adipose tissue	84.7 nTPM
Stomach	55.0 nTPM
PBMC	34.3 nTPM
Kidney	33.4 nTPM
Bone marrow	32.7 nTPM

Basal keratinocytes	121.0 nTPM
Skin	121.0 nTPM

Basal prostatic cells	90.0 nTPM
Prostate	90.0 nTPM

Adipocytes	2511.2 nTPM
Breast	3706.1 nTPM
Adipose tissue	1316.4 nTPM

Basal squamous epithelial cells	727.3 nTPM
Esophagus	727.3 nTPM

Dendritic cells	97.5 nTPM
Breast	138.9 nTPM
PBMC	103.6 nTPM
Adipose tissue	49.8 nTPM

Endothelial cells	662.2 nTPM
Skeletal muscle	2913.1 nTPM
Pancreas	2053.9 nTPM
Breast	1154.2 nTPM
Testis	553.5 nTPM
Esophagus	540.2 nTPM
Placenta	496.8 nTPM
Ovary	451.2 nTPM
Lung	427.3 nTPM
Skin	384.6 nTPM
Heart muscle	173.1 nTPM
Endometrium	63.6 nTPM
Prostate	38.2 nTPM
Eye	13.7 nTPM
Liver	7.3 nTPM

Enteroendocrine cells	197.2 nTPM
Rectum	199.0 nTPM
Colon	195.4 nTPM

Fibroblasts	140.6 nTPM
Stomach	399.5 nTPM
Lung	297.2 nTPM
Ovary	242.5 nTPM
Prostate	161.5 nTPM
Placenta	120.3 nTPM
Breast	84.7 nTPM
Skin	68.6 nTPM
Adipose tissue	67.4 nTPM
Esophagus	50.5 nTPM
Skeletal muscle	37.8 nTPM
Heart muscle	16.4 nTPM

Intestinal goblet cells	216.3 nTPM
Colon	393.8 nTPM
Rectum	141.3 nTPM
Small intestine	113.9 nTPM

Macrophages	405.5 nTPM
Pancreas	1245.5 nTPM
Prostate	840.2 nTPM
Lung	723.9 nTPM
Breast	654.4 nTPM
Kidney	575.5 nTPM
Ovary	473.1 nTPM
Spleen	312.1 nTPM
Esophagus	262.8 nTPM
Endometrium	239.2 nTPM
Adipose tissue	237.6 nTPM
Skeletal muscle	185.7 nTPM
Testis	134.8 nTPM
Bone marrow	93.7 nTPM
Stomach	90.8 nTPM
PBMC	13.6 nTPM

Paneth cells	561.0 nTPM
Colon	1067.2 nTPM
Rectum	507.2 nTPM
Small intestine	108.8 nTPM

Plasma cells	132.9 nTPM
Spleen	283.5 nTPM
Bone marrow	204.4 nTPM
Esophagus	98.5 nTPM
Stomach	45.2 nTPM
Adipose tissue	32.8 nTPM

Cholangiocytes	2.8 nTPM
Liver	2.8 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Cone photoreceptor cells	45.9 nTPM
Eye	45.9 nTPM

Cytotrophoblasts	28.0 nTPM
Placenta	28.0 nTPM

Respiratory ciliated cells	115.7 nTPM
Bronchus	122.0 nTPM
Lung	109.3 nTPM

Smooth muscle cells	336.8 nTPM
Skeletal muscle	1281.0 nTPM
Adipose tissue	729.7 nTPM
Ovary	565.3 nTPM
Breast	341.4 nTPM
Esophagus	212.4 nTPM
Pancreas	192.5 nTPM
Bronchus	134.4 nTPM
Skin	84.0 nTPM
Endometrium	78.2 nTPM
Heart muscle	43.5 nTPM
Prostate	42.5 nTPM

T-cells	102.3 nTPM
Breast	300.0 nTPM
Esophagus	163.7 nTPM
Colon	145.9 nTPM
Skin	119.3 nTPM
Endometrium	118.0 nTPM
Stomach	117.4 nTPM
Adipose tissue	107.0 nTPM
Prostate	99.4 nTPM
Lymph node	99.2 nTPM
Spleen	87.8 nTPM
Lung	82.0 nTPM
Skeletal muscle	72.9 nTPM
Ovary	66.8 nTPM
Liver	54.6 nTPM
Bone marrow	42.1 nTPM
Kidney	34.2 nTPM
PBMC	29.5 nTPM

Undifferentiated cells	419.2 nTPM
Colon	807.7 nTPM
Rectum	349.4 nTPM
Small intestine	100.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC