Single cell type - ALDH7A1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALDH7A1
Gene descriptionⁱ Full gene name according to HGNC.	Aldehyde dehydrogenase 7 family member A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts, Proximal tubular cells, Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HBEC3-KT)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, Proximal tubular cells, Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ALDH7A1 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PAGE4	PAGE family member 4	0.8379	47
MYORG	Myogenesis regulating glycosidase (putative)	0.8339	47
SMIM43	Small integral membrane protein 43	0.8303	47
SOX14	SRY-box transcription factor 14	0.8296	47
MTARC1	Mitochondrial amidoxime reducing component 1	0.8253	47
IL36RN	Interleukin 36 receptor antagonist	0.8202	47
MAGEA8	MAGE family member A8	0.8144	47
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.8092	47
SMAGP	Small cell adhesion glycoprotein	0.8033	47
LARGE2	LARGE xylosyl- and glucuronyltransferase 2	0.8025	47
FBN2	Fibrillin 2	0.7916	47
GSDME	Gasdermin E	0.7909	47
RTL8B	Retrotransposon Gag like 8B	0.7906	47
XAGE3	X antigen family member 3	0.7900	47
MAB21L4	Mab-21 like 4	0.7888	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.6 nTPM
Breast	19.3 nTPM
Adipose tissue	15.9 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	29.3 nTPM
Lung	29.3 nTPM

Astrocytes	99.3 nTPM
Brain	99.3 nTPM

B-cells	5.0 nTPM
Kidney	33.4 nTPM
Liver	8.7 nTPM
Breast	2.6 nTPM
Bone marrow	1.7 nTPM
Adipose tissue	1.5 nTPM
Lymph node	0.9 nTPM
Spleen	0.7 nTPM
Stomach	0.5 nTPM
Colon	0.0 nTPM
PBMC	0.0 nTPM

Dendritic cells	3.7 nTPM
PBMC	4.0 nTPM
Adipose tissue	3.9 nTPM
Breast	3.3 nTPM

Endothelial cells	19.1 nTPM
Placenta	31.8 nTPM
Ovary	27.9 nTPM
Endometrium	23.0 nTPM
Eye	20.3 nTPM
Testis	19.6 nTPM
Pancreas	19.3 nTPM
Breast	19.3 nTPM
Esophagus	18.6 nTPM
Skeletal muscle	16.0 nTPM
Lung	15.6 nTPM
Heart muscle	15.1 nTPM
Liver	14.7 nTPM
Prostate	12.9 nTPM
Skin	12.9 nTPM

Fibroblasts	34.0 nTPM
Ovary	84.2 nTPM
Placenta	50.1 nTPM
Breast	36.7 nTPM
Lung	34.7 nTPM
Heart muscle	33.4 nTPM
Adipose tissue	28.5 nTPM
Esophagus	26.2 nTPM
Skeletal muscle	25.2 nTPM
Stomach	23.7 nTPM
Skin	16.0 nTPM
Prostate	15.2 nTPM

Intestinal goblet cells	25.9 nTPM
Rectum	33.4 nTPM
Colon	24.3 nTPM
Small intestine	20.0 nTPM

Macrophages	9.1 nTPM
Kidney	24.9 nTPM
Esophagus	18.9 nTPM
Ovary	18.8 nTPM
Adipose tissue	13.5 nTPM
Testis	11.1 nTPM
Endometrium	10.6 nTPM
Breast	10.3 nTPM
Lung	8.9 nTPM
Prostate	8.1 nTPM
Skeletal muscle	6.9 nTPM
Pancreas	2.5 nTPM
Bone marrow	1.2 nTPM
Spleen	1.0 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	15.6 nTPM
Rectum	33.3 nTPM
Colon	9.9 nTPM
Small intestine	3.7 nTPM

Plasma cells	2.0 nTPM
Adipose tissue	3.9 nTPM
Stomach	2.6 nTPM
Spleen	1.9 nTPM
Bone marrow	1.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	23.4 nTPM
Bronchus	25.0 nTPM
Lung	21.9 nTPM

Smooth muscle cells	25.8 nTPM
Pancreas	47.9 nTPM
Ovary	42.5 nTPM
Endometrium	41.7 nTPM
Breast	25.1 nTPM
Bronchus	23.5 nTPM
Adipose tissue	19.5 nTPM
Prostate	19.4 nTPM
Skin	18.8 nTPM
Skeletal muscle	17.8 nTPM
Esophagus	15.5 nTPM
Heart muscle	11.7 nTPM

T-cells	4.6 nTPM
Kidney	26.0 nTPM
Endometrium	9.7 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM
Prostate	4.7 nTPM
Lung	4.5 nTPM
Liver	4.4 nTPM
Breast	4.2 nTPM
Adipose tissue	3.8 nTPM
Skin	3.3 nTPM
Colon	1.4 nTPM
Lymph node	0.9 nTPM
Skeletal muscle	0.8 nTPM
PBMC	0.7 nTPM
Spleen	0.7 nTPM
Bone marrow	0.4 nTPM
Stomach	0.2 nTPM

Basal prostatic cells	59.5 nTPM
Prostate	59.5 nTPM

Basal respiratory cells	110.0 nTPM
Bronchus	110.0 nTPM

Basal squamous epithelial cells	87.0 nTPM
Esophagus	87.0 nTPM

Cholangiocytes	27.1 nTPM
Liver	27.1 nTPM

Undifferentiated cells	46.4 nTPM
Small intestine	50.5 nTPM
Rectum	49.7 nTPM
Colon	39.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC