Single cell type - BAALC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BAALC
Gene descriptionⁱ Full gene name according to HGNC.	BAALC binder of MAP3K1 and KLF4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Astrocytes, Muller glia cells, Excitatory neurons, Oligodendrocyte precursor cells, Adipocytes, Inhibitory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (NK-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AF22, BJ hTERT+, SCLC-21H, SH-SY5Y, U-87 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Astrocytes, Muller glia cells, Excitatory neurons, Oligodendrocyte precursor cells, Adipocytes, Inhibitory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BAALC is part of cluster 21 Neurons & Oligodendrocytes - Neuronal signaling with confidenceⁱ 1
589 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TRPM3	Transient receptor potential cation channel subfamily M member 3	0.7632	21
NAV3	Neuron navigator 3	0.6853	21
OR51B5	Olfactory receptor family 51 subfamily B member 5	0.6638	21
FMN2	Formin 2	0.6626	21
OR3A1	Olfactory receptor family 3 subfamily A member 1	0.6577	21
MAPK10	Mitogen-activated protein kinase 10	0.6548	21
FOXP2	Forkhead box P2	0.6533	21
TLL1	Tolloid like 1	0.6486	21
ADAMTSL1	ADAMTS like 1	0.6474	21
ASIC2	Acid sensing ion channel subunit 2	0.6448	21
HS3ST4	Heparan sulfate-glucosamine 3-sulfotransferase 4	0.6400	21
OLFM3	Olfactomedin 3	0.6349	21
SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1	0.6336	21
FAM155A	Family with sequence similarity 155 member A	0.6283	21
PTPRD	Protein tyrosine phosphatase receptor type D	0.6224	21

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	1.8 nTPM
Lung	1.8 nTPM

B-cells	0.3 nTPM
Liver	1.8 nTPM
Adipose tissue	1.5 nTPM
Lymph node	0.1 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Basal keratinocytes	5.5 nTPM
Skin	5.5 nTPM

Basal prostatic cells	0.7 nTPM
Prostate	0.7 nTPM

Dendritic cells	2.1 nTPM
Adipose tissue	3.6 nTPM
Breast	2.5 nTPM
PBMC	0.0 nTPM

Endothelial cells	33.4 nTPM
Placenta	64.8 nTPM
Breast	64.1 nTPM
Testis	59.5 nTPM
Skin	50.6 nTPM
Skeletal muscle	37.9 nTPM
Ovary	37.5 nTPM
Liver	36.7 nTPM
Heart muscle	24.8 nTPM
Esophagus	23.4 nTPM
Eye	20.3 nTPM
Pancreas	15.5 nTPM
Endometrium	11.8 nTPM
Prostate	11.5 nTPM
Lung	9.3 nTPM

Fibroblasts	1.6 nTPM
Skin	6.3 nTPM
Lung	3.4 nTPM
Heart muscle	2.8 nTPM
Placenta	1.5 nTPM
Prostate	1.5 nTPM
Skeletal muscle	0.7 nTPM
Breast	0.6 nTPM
Esophagus	0.3 nTPM
Ovary	0.2 nTPM
Adipose tissue	0.1 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	3.4 nTPM
Small intestine	10.2 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	2.1 nTPM
Pancreas	23.0 nTPM
Ovary	2.5 nTPM
Prostate	2.2 nTPM
Endometrium	1.7 nTPM
Breast	0.7 nTPM
Lung	0.6 nTPM
Testis	0.6 nTPM
Skeletal muscle	0.4 nTPM
Adipose tissue	0.2 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	1.2 nTPM
Small intestine	3.7 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	0.8 nTPM
Adipose tissue	3.9 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	21.7 nTPM
Bronchus	24.4 nTPM
Lung	19.0 nTPM

Smooth muscle cells	8.1 nTPM
Pancreas	60.0 nTPM
Bronchus	8.4 nTPM
Skin	6.4 nTPM
Endometrium	4.0 nTPM
Heart muscle	3.3 nTPM
Skeletal muscle	1.9 nTPM
Breast	1.7 nTPM
Esophagus	1.5 nTPM
Prostate	1.3 nTPM
Ovary	0.4 nTPM
Adipose tissue	0.4 nTPM

T-cells	1.3 nTPM
Liver	9.2 nTPM
Endometrium	5.3 nTPM
Ovary	2.2 nTPM
Skin	1.9 nTPM
Lung	1.5 nTPM
Spleen	0.9 nTPM
Breast	0.6 nTPM
Colon	0.5 nTPM
Skeletal muscle	0.5 nTPM
Bone marrow	0.2 nTPM
PBMC	0.1 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Stomach	0.0 nTPM

Astrocytes	198.2 nTPM
Brain	198.2 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Distal tubular cells	7.9 nTPM
Kidney	7.9 nTPM

Early spermatids	2.9 nTPM
Testis	2.9 nTPM

Undifferentiated cells	0.1 nTPM
Small intestine	0.2 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC