Single cell type - FBP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FBP1
Gene descriptionⁱ Full gene name according to HGNC.	Fructose-bisphosphatase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Hepatocytes, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HaCaT, MCF7, OE19, RT4, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Hepatocytes, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FBP1 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GPD1	Glycerol-3-phosphate dehydrogenase 1	0.7997	67
DHDH	Dihydrodiol dehydrogenase	0.7622	67
KHK	Ketohexokinase	0.7622	67
SLC28A1	Solute carrier family 28 member 1	0.7600	67
PEPD	Peptidase D	0.7591	67
ERICH4	Glutamate rich 4	0.7515	67
GCHFR	GTP cyclohydrolase I feedback regulator	0.7470	2
CMBL	Carboxymethylenebutenolidase homolog	0.7438	67
DHRS4L2	Dehydrogenase/reductase 4 like 2	0.7353	67
AKR7A3	Aldo-keto reductase family 7 member A3	0.7276	67
SLC34A3	Solute carrier family 34 member 3	0.7198	67
ALDOB	Aldolase, fructose-bisphosphate B	0.7145	67
FAM151A	Family with sequence similarity 151 member A	0.7129	67
PCK1	Phosphoenolpyruvate carboxykinase 1	0.7098	67
CRYL1	Crystallin lambda 1	0.7042	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.8 nTPM
Breast	3.1 nTPM
Adipose tissue	2.4 nTPM

Alveolar cells type 1	76.9 nTPM
Lung	76.9 nTPM

Alveolar cells type 2	182.8 nTPM
Lung	182.8 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	10.3 nTPM
Kidney	23.8 nTPM
Liver	21.2 nTPM
Breast	17.3 nTPM
Stomach	11.3 nTPM
Lymph node	6.9 nTPM
Colon	6.4 nTPM
Spleen	5.5 nTPM
PBMC	4.3 nTPM
Bone marrow	4.1 nTPM
Adipose tissue	2.0 nTPM

Dendritic cells	14.8 nTPM
PBMC	27.9 nTPM
Adipose tissue	10.3 nTPM
Breast	6.2 nTPM

Endothelial cells	4.8 nTPM
Lung	24.9 nTPM
Eye	20.3 nTPM
Liver	7.3 nTPM
Breast	4.3 nTPM
Placenta	4.0 nTPM
Prostate	2.1 nTPM
Heart muscle	1.2 nTPM
Esophagus	1.0 nTPM
Skin	0.9 nTPM
Endometrium	0.9 nTPM
Skeletal muscle	0.5 nTPM
Testis	0.3 nTPM
Pancreas	0.0 nTPM
Ovary	0.0 nTPM

Fibroblasts	5.4 nTPM
Lung	30.1 nTPM
Stomach	7.4 nTPM
Skeletal muscle	5.2 nTPM
Esophagus	5.0 nTPM
Heart muscle	3.8 nTPM
Adipose tissue	2.5 nTPM
Placenta	2.1 nTPM
Breast	2.0 nTPM
Skin	1.1 nTPM
Prostate	0.2 nTPM
Ovary	0.1 nTPM

Intestinal goblet cells	61.4 nTPM
Small intestine	109.2 nTPM
Rectum	48.5 nTPM
Colon	26.4 nTPM

Macrophages	238.6 nTPM
Lung	1284.6 nTPM
Pancreas	1026.1 nTPM
Kidney	270.0 nTPM
Stomach	146.6 nTPM
Endometrium	144.9 nTPM
Bone marrow	121.2 nTPM
Ovary	84.5 nTPM
Adipose tissue	82.5 nTPM
Spleen	80.9 nTPM
Testis	80.2 nTPM
Prostate	78.0 nTPM
Breast	64.7 nTPM
Skeletal muscle	61.3 nTPM
Esophagus	53.5 nTPM
PBMC	0.0 nTPM

Paneth cells	77.6 nTPM
Small intestine	154.0 nTPM
Rectum	75.5 nTPM
Colon	3.3 nTPM

Plasma cells	18.3 nTPM
Stomach	27.7 nTPM
Adipose tissue	26.4 nTPM
Esophagus	24.6 nTPM
Bone marrow	9.9 nTPM
Spleen	2.9 nTPM

Respiratory ciliated cells	9.1 nTPM
Lung	14.6 nTPM
Bronchus	3.6 nTPM

Smooth muscle cells	2.0 nTPM
Ovary	6.7 nTPM
Bronchus	3.7 nTPM
Heart muscle	3.2 nTPM
Breast	2.1 nTPM
Esophagus	1.5 nTPM
Adipose tissue	1.4 nTPM
Prostate	1.3 nTPM
Skin	1.1 nTPM
Pancreas	1.0 nTPM
Endometrium	0.6 nTPM
Skeletal muscle	0.0 nTPM

T-cells	12.1 nTPM
Lung	56.2 nTPM
Kidney	34.2 nTPM
Liver	26.8 nTPM
Ovary	15.6 nTPM
Prostate	14.2 nTPM
Lymph node	12.6 nTPM
PBMC	8.5 nTPM
Endometrium	6.2 nTPM
Spleen	6.0 nTPM
Breast	4.8 nTPM
Bone marrow	4.6 nTPM
Colon	4.3 nTPM
Stomach	3.9 nTPM
Skeletal muscle	3.0 nTPM
Adipose tissue	2.7 nTPM
Skin	1.9 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	0.8 nTPM
Skin	0.8 nTPM

Basal prostatic cells	8.9 nTPM
Prostate	8.9 nTPM

Basal respiratory cells	0.7 nTPM
Bronchus	0.7 nTPM

Cholangiocytes	102.9 nTPM
Liver	102.9 nTPM

Undifferentiated cells	90.4 nTPM
Small intestine	146.5 nTPM
Rectum	65.9 nTPM
Colon	59.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC