Single cell type - CARD19 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CARD19
Gene descriptionⁱ Full gene name according to HGNC.	Caspase recruitment domain family member 19
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Macrophages, Pancreatic endocrine cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Macrophages, Pancreatic endocrine cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CARD19 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RUFY1	RUN and FYVE domain containing 1	0.7252	51
FERMT3	Fermitin family member 3	0.7224	51
TREML1	Triggering receptor expressed on myeloid cells like 1	0.7140	51
TRAPPC3L	Trafficking protein particle complex 3 like	0.7090	51
SMOX	Spermine oxidase	0.7068	51
RGS18	Regulator of G protein signaling 18	0.7057	51
LY6G5C	Lymphocyte antigen 6 family member G5C	0.7042	51
CDKN2D	Cyclin dependent kinase inhibitor 2D	0.7021	51
LGALS12	Galectin 12	0.6996	51
PPBP	Pro-platelet basic protein	0.6980	51
HBG1	Hemoglobin subunit gamma 1	0.6980	51
MMD	Monocyte to macrophage differentiation associated	0.6952	51
HBG2	Hemoglobin subunit gamma 2	0.6927	51
PF4	Platelet factor 4	0.6918	51
LY6G6F	Lymphocyte antigen 6 family member G6F	0.6891	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.3 nTPM
Breast	30.2 nTPM
Adipose tissue	28.3 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	20.9 nTPM
Lung	20.9 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	14.4 nTPM
PBMC	31.5 nTPM
Breast	26.8 nTPM
Liver	23.5 nTPM
Adipose tissue	16.1 nTPM
Kidney	14.3 nTPM
Lymph node	10.3 nTPM
Stomach	8.6 nTPM
Spleen	7.6 nTPM
Bone marrow	5.7 nTPM
Colon	0.0 nTPM

Dendritic cells	25.7 nTPM
Breast	45.9 nTPM
Adipose tissue	27.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	34.1 nTPM
Prostate	71.1 nTPM
Pancreas	57.9 nTPM
Testis	56.0 nTPM
Placenta	51.2 nTPM
Breast	45.2 nTPM
Esophagus	40.3 nTPM
Ovary	37.5 nTPM
Eye	35.6 nTPM
Skeletal muscle	26.2 nTPM
Endometrium	25.9 nTPM
Liver	24.7 nTPM
Lung	6.2 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM

Fibroblasts	26.2 nTPM
Prostate	62.7 nTPM
Placenta	37.8 nTPM
Stomach	34.1 nTPM
Lung	31.3 nTPM
Breast	31.2 nTPM
Skeletal muscle	25.7 nTPM
Adipose tissue	24.4 nTPM
Esophagus	23.0 nTPM
Ovary	18.1 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	19.8 nTPM
Rectum	32.5 nTPM
Small intestine	27.0 nTPM
Colon	0.0 nTPM

Macrophages	142.0 nTPM
PBMC	995.8 nTPM
Pancreas	229.7 nTPM
Prostate	201.7 nTPM
Testis	105.1 nTPM
Adipose tissue	70.5 nTPM
Kidney	70.4 nTPM
Stomach	70.3 nTPM
Skeletal muscle	64.8 nTPM
Breast	63.6 nTPM
Esophagus	53.5 nTPM
Bone marrow	52.4 nTPM
Ovary	43.7 nTPM
Endometrium	39.6 nTPM
Lung	36.0 nTPM
Spleen	32.1 nTPM

Paneth cells	10.3 nTPM
Rectum	23.2 nTPM
Small intestine	7.5 nTPM
Colon	0.0 nTPM

Plasma cells	15.0 nTPM
Adipose tissue	18.8 nTPM
Esophagus	18.4 nTPM
Bone marrow	16.5 nTPM
Spleen	11.7 nTPM
Stomach	9.7 nTPM

Respiratory ciliated cells	2.2 nTPM
Lung	4.4 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	31.1 nTPM
Prostate	106.3 nTPM
Pancreas	56.6 nTPM
Breast	45.7 nTPM
Esophagus	32.5 nTPM
Skeletal muscle	29.1 nTPM
Endometrium	25.5 nTPM
Adipose tissue	25.3 nTPM
Ovary	21.7 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	34.0 nTPM
Prostate	66.3 nTPM
Breast	52.9 nTPM
Ovary	46.7 nTPM
Esophagus	45.9 nTPM
Adipose tissue	45.8 nTPM
Lung	45.6 nTPM
PBMC	44.7 nTPM
Kidney	41.1 nTPM
Skeletal muscle	40.3 nTPM
Endometrium	33.7 nTPM
Liver	30.5 nTPM
Spleen	24.1 nTPM
Lymph node	21.6 nTPM
Stomach	21.4 nTPM
Bone marrow	17.8 nTPM
Colon	0.0 nTPM
Skin	0.0 nTPM

Basal prostatic cells	52.8 nTPM
Prostate	52.8 nTPM

Basal squamous epithelial cells	25.6 nTPM
Esophagus	25.6 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Cytotrophoblasts	22.9 nTPM
Placenta	22.9 nTPM

Undifferentiated cells	18.6 nTPM
Rectum	33.9 nTPM
Small intestine	21.9 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC