Single cell type - DDX21 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDX21
Gene descriptionⁱ Full gene name according to HGNC.	DExD-box helicase 21
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DDX21 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.95
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZBTB21	Zinc finger and BTB domain containing 21	0.6945	39
NOM1	Nucleolar protein with MIF4G domain 1	0.6478	39
PPRC1	PPARG related coactivator 1	0.6360	44
NOLC1	Nucleolar and coiled-body phosphoprotein 1	0.6273	39
WDR43	WD repeat domain 43	0.6208	44
GPATCH4	G-patch domain containing 4	0.6069	39
PNO1	Partner of NOB1 homolog	0.6055	39
IPO7	Importin 7	0.6021	10
CHD1	Chromodomain helicase DNA binding protein 1	0.6009	41
RLIM	Ring finger protein, LIM domain interacting	0.6000	41
EIF1AX	Eukaryotic translation initiation factor 1A X-linked	0.5892	39
ZNF593	Zinc finger protein 593	0.5834	39
SEH1L	SEH1 like nucleoporin	0.5806	39
GNL3	G protein nucleolar 3	0.5743	39
TAF1D	TATA-box binding protein associated factor, RNA polymerase I subunit D	0.5732	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	199.4 nTPM
Adipose tissue	296.3 nTPM
Breast	102.4 nTPM

Alveolar cells type 1	102.5 nTPM
Lung	102.5 nTPM

Alveolar cells type 2	141.6 nTPM
Lung	141.6 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	243.7 nTPM
Adipose tissue	599.0 nTPM
Colon	383.4 nTPM
Spleen	279.6 nTPM
Liver	273.7 nTPM
Stomach	244.3 nTPM
Lymph node	182.6 nTPM
Breast	176.5 nTPM
Bone marrow	116.9 nTPM
Kidney	95.3 nTPM
PBMC	85.6 nTPM

Basal squamous epithelial cells	174.2 nTPM
Esophagus	174.2 nTPM

Dendritic cells	139.5 nTPM
Adipose tissue	214.5 nTPM
Breast	128.3 nTPM
PBMC	75.7 nTPM

Endothelial cells	196.7 nTPM
Prostate	601.9 nTPM
Lung	361.8 nTPM
Skin	275.7 nTPM
Skeletal muscle	257.5 nTPM
Placenta	184.8 nTPM
Endometrium	176.4 nTPM
Pancreas	150.6 nTPM
Esophagus	143.4 nTPM
Liver	133.9 nTPM
Breast	129.9 nTPM
Ovary	115.1 nTPM
Testis	85.0 nTPM
Heart muscle	82.3 nTPM
Eye	55.8 nTPM

Enteroendocrine cells	86.7 nTPM
Colon	103.1 nTPM
Rectum	70.4 nTPM

Fibroblasts	162.2 nTPM
Prostate	430.1 nTPM
Lung	225.6 nTPM
Skeletal muscle	217.4 nTPM
Skin	199.6 nTPM
Adipose tissue	165.4 nTPM
Stomach	139.6 nTPM
Heart muscle	115.8 nTPM
Placenta	84.2 nTPM
Ovary	83.2 nTPM
Breast	74.9 nTPM
Esophagus	48.0 nTPM

Intestinal goblet cells	202.7 nTPM
Colon	417.4 nTPM
Small intestine	97.2 nTPM
Rectum	93.5 nTPM

Macrophages	199.1 nTPM
Adipose tissue	505.8 nTPM
Lung	303.1 nTPM
Endometrium	289.4 nTPM
Skeletal muscle	246.9 nTPM
Kidney	214.8 nTPM
Stomach	213.9 nTPM
Spleen	202.2 nTPM
Testis	188.8 nTPM
Esophagus	174.7 nTPM
Breast	158.1 nTPM
Prostate	152.5 nTPM
Bone marrow	148.7 nTPM
Pancreas	94.4 nTPM
Ovary	79.1 nTPM
PBMC	13.6 nTPM

Paneth cells	77.7 nTPM
Colon	105.4 nTPM
Rectum	105.0 nTPM
Small intestine	22.5 nTPM

Plasma cells	148.9 nTPM
Spleen	188.3 nTPM
Adipose tissue	178.7 nTPM
Bone marrow	156.5 nTPM
Esophagus	123.1 nTPM
Stomach	97.8 nTPM

Respiratory ciliated cells	72.8 nTPM
Lung	90.3 nTPM
Bronchus	55.3 nTPM

Collecting duct cells	71.7 nTPM
Kidney	71.7 nTPM

Cone photoreceptor cells	41.7 nTPM
Eye	41.7 nTPM

Cytotrophoblasts	80.8 nTPM
Placenta	80.8 nTPM

Distal enterocytes	134.0 nTPM
Colon	239.9 nTPM
Rectum	28.1 nTPM

Smooth muscle cells	174.9 nTPM
Prostate	487.7 nTPM
Skeletal muscle	325.4 nTPM
Skin	233.7 nTPM
Pancreas	180.4 nTPM
Adipose tissue	167.8 nTPM
Endometrium	166.0 nTPM
Ovary	95.6 nTPM
Heart muscle	94.1 nTPM
Esophagus	89.9 nTPM
Breast	67.1 nTPM
Bronchus	16.1 nTPM

T-cells	159.6 nTPM
Adipose tissue	320.0 nTPM
Endometrium	244.5 nTPM
Skin	217.4 nTPM
Lymph node	189.3 nTPM
Lung	183.8 nTPM
Colon	181.5 nTPM
Prostate	179.9 nTPM
Spleen	169.1 nTPM
Skeletal muscle	168.2 nTPM
Breast	167.9 nTPM
Stomach	140.3 nTPM
PBMC	112.8 nTPM
Esophagus	104.8 nTPM
Liver	94.6 nTPM
Kidney	89.6 nTPM
Bone marrow	87.6 nTPM
Ovary	62.3 nTPM

Undifferentiated cells	210.7 nTPM
Colon	395.7 nTPM
Small intestine	129.0 nTPM
Rectum	107.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC