Single cell type - IKBIP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IKBIP
Gene descriptionⁱ Full gene name according to HGNC.	IKBKB interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

IKBIP is part of cluster 33 Fibroblasts - ECM organization with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GPX7	Glutathione peroxidase 7	0.7074	33
FKBP10	FKBP prolyl isomerase 10	0.6283	33
MFAP2	Microfibril associated protein 2	0.6200	33
INKA2	Inka box actin regulator 2	0.6077	33
P3H1	Prolyl 3-hydroxylase 1	0.6060	33
LOXL2	Lysyl oxidase like 2	0.6045	33
CTHRC1	Collagen triple helix repeat containing 1	0.5795	33
ARSI	Arylsulfatase family member I	0.5771	33
NID2	Nidogen 2	0.5764	33
COL5A1	Collagen type V alpha 1 chain	0.5739	33
RCN3	Reticulocalbin 3	0.5671	33
COL3A1	Collagen type III alpha 1 chain	0.5633	33
WNT2	Wnt family member 2	0.5584	33
SPARC	Secreted protein acidic and cysteine rich	0.5525	33
CYTL1	Cytokine like 1	0.5511	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	44.9 nTPM
Breast	53.4 nTPM
Adipose tissue	36.4 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	15.7 nTPM
Lung	15.7 nTPM

Astrocytes	1.6 nTPM
Brain	1.6 nTPM

B-cells	34.4 nTPM
Liver	62.7 nTPM
Adipose tissue	46.7 nTPM
Stomach	41.8 nTPM
Spleen	34.6 nTPM
PBMC	32.9 nTPM
Lymph node	32.3 nTPM
Colon	31.9 nTPM
Breast	26.8 nTPM
Bone marrow	20.4 nTPM
Kidney	14.3 nTPM

Dendritic cells	32.5 nTPM
Adipose tissue	42.1 nTPM
PBMC	27.9 nTPM
Breast	27.4 nTPM

Endothelial cells	47.7 nTPM
Placenta	78.4 nTPM
Ovary	76.1 nTPM
Liver	70.6 nTPM
Pancreas	61.8 nTPM
Prostate	56.6 nTPM
Skeletal muscle	45.0 nTPM
Skin	44.4 nTPM
Endometrium	43.5 nTPM
Testis	41.8 nTPM
Breast	40.1 nTPM
Lung	34.3 nTPM
Esophagus	31.5 nTPM
Eye	21.8 nTPM
Heart muscle	21.8 nTPM

Fibroblasts	47.0 nTPM
Placenta	101.0 nTPM
Lung	55.9 nTPM
Adipose tissue	55.8 nTPM
Breast	55.8 nTPM
Ovary	53.8 nTPM
Skeletal muscle	48.7 nTPM
Skin	37.3 nTPM
Prostate	36.6 nTPM
Heart muscle	27.2 nTPM
Esophagus	22.3 nTPM
Stomach	22.3 nTPM

Intestinal goblet cells	4.8 nTPM
Colon	6.5 nTPM
Small intestine	4.6 nTPM
Rectum	3.4 nTPM

Macrophages	35.4 nTPM
Testis	72.1 nTPM
Breast	49.2 nTPM
Adipose tissue	48.7 nTPM
Esophagus	47.2 nTPM
Lung	43.9 nTPM
Pancreas	40.8 nTPM
Kidney	39.4 nTPM
Endometrium	34.5 nTPM
Prostate	32.0 nTPM
Skeletal muscle	31.5 nTPM
Ovary	28.5 nTPM
Bone marrow	25.0 nTPM
Stomach	20.5 nTPM
Spleen	17.6 nTPM
PBMC	0.0 nTPM

Paneth cells	3.1 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM
Rectum	2.4 nTPM

Plasma cells	74.8 nTPM
Stomach	92.8 nTPM
Spleen	91.4 nTPM
Bone marrow	75.8 nTPM
Esophagus	74.0 nTPM
Adipose tissue	40.0 nTPM

Respiratory ciliated cells	6.3 nTPM
Bronchus	6.8 nTPM
Lung	5.8 nTPM

Smooth muscle cells	46.8 nTPM
Pancreas	205.9 nTPM
Ovary	64.6 nTPM
Endometrium	58.4 nTPM
Bronchus	52.4 nTPM
Breast	27.6 nTPM
Adipose tissue	23.5 nTPM
Prostate	21.6 nTPM
Skeletal muscle	21.6 nTPM
Skin	19.2 nTPM
Esophagus	10.9 nTPM
Heart muscle	8.7 nTPM

T-cells	23.6 nTPM
Ovary	51.2 nTPM
Prostate	47.3 nTPM
Adipose tissue	32.4 nTPM
Liver	23.2 nTPM
Skin	23.0 nTPM
Bone marrow	22.5 nTPM
Stomach	22.2 nTPM
Kidney	22.0 nTPM
Spleen	20.7 nTPM
Breast	18.9 nTPM
PBMC	18.8 nTPM
Skeletal muscle	18.5 nTPM
Colon	17.6 nTPM
Endometrium	17.5 nTPM
Lung	16.7 nTPM
Lymph node	16.1 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	7.6 nTPM
Skin	7.6 nTPM

Basal prostatic cells	15.5 nTPM
Prostate	15.5 nTPM

Basal respiratory cells	55.6 nTPM
Bronchus	55.6 nTPM

Cone photoreceptor cells	4.2 nTPM
Eye	4.2 nTPM

Undifferentiated cells	2.9 nTPM
Colon	3.5 nTPM
Small intestine	2.8 nTPM
Rectum	2.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC