Single cell type - NDUFB8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFB8
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit B8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFB8 is part of cluster 7 Non-specific - Mitochondria with confidenceⁱ 1
481 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UQCC3	Ubiquinol-cytochrome c reductase complex assembly factor 3	0.6514	7
BORCS8	BLOC-1 related complex subunit 8	0.6214	7
BORCS7	BLOC-1 related complex subunit 7	0.6061	39
IER3IP1	Immediate early response 3 interacting protein 1	0.6011	67
AK6	Adenylate kinase 6	0.5854	25
UQCR11	Ubiquinol-cytochrome c reductase, complex III subunit XI	0.5851	39
MMP24OS	MMP24 opposite strand	0.5812	7
SF3B6	Splicing factor 3b subunit 6	0.5753	22
COPS9	COP9 signalosome subunit 9	0.5718	7
ATP5MG	ATP synthase membrane subunit g	0.5672	7
ATP5MD	ATP synthase membrane subunit DAPIT	0.5641	7
ATP5PF	ATP synthase peripheral stalk subunit F6	0.5624	7
COX4I1	Cytochrome c oxidase subunit 4I1	0.5618	39
COX7C	Cytochrome c oxidase subunit 7C	0.5586	39
SDHAF3	Succinate dehydrogenase complex assembly factor 3	0.5580	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	184.8 nTPM
Breast	243.3 nTPM
Adipose tissue	126.3 nTPM

Alveolar cells type 1	76.9 nTPM
Lung	76.9 nTPM

Alveolar cells type 2	132.7 nTPM
Lung	132.7 nTPM

Astrocytes	41.8 nTPM
Brain	41.8 nTPM

B-cells	107.6 nTPM
Liver	403.7 nTPM
Kidney	180.9 nTPM
Breast	155.2 nTPM
PBMC	151.3 nTPM
Adipose tissue	82.2 nTPM
Bone marrow	29.4 nTPM
Lymph node	25.8 nTPM
Spleen	24.3 nTPM
Stomach	23.6 nTPM
Colon	0.0 nTPM

Dendritic cells	175.8 nTPM
Breast	199.8 nTPM
PBMC	175.3 nTPM
Adipose tissue	152.3 nTPM

Endothelial cells	142.7 nTPM
Pancreas	324.3 nTPM
Placenta	240.5 nTPM
Breast	211.6 nTPM
Liver	165.1 nTPM
Testis	155.3 nTPM
Heart muscle	145.1 nTPM
Eye	141.6 nTPM
Prostate	133.8 nTPM
Ovary	132.9 nTPM
Skeletal muscle	120.7 nTPM
Lung	118.5 nTPM
Endometrium	83.6 nTPM
Esophagus	24.3 nTPM
Skin	0.0 nTPM

Enteroendocrine cells	105.6 nTPM
Rectum	211.1 nTPM
Colon	0.0 nTPM

Erythroid cells	114.3 nTPM
Liver	187.3 nTPM
Bone marrow	41.2 nTPM

Fibroblasts	128.8 nTPM
Heart muscle	269.5 nTPM
Placenta	255.4 nTPM
Breast	196.6 nTPM
Adipose tissue	165.8 nTPM
Ovary	161.0 nTPM
Prostate	154.1 nTPM
Skeletal muscle	115.4 nTPM
Lung	59.2 nTPM
Esophagus	20.6 nTPM
Stomach	19.3 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	171.6 nTPM
Small intestine	277.0 nTPM
Rectum	237.7 nTPM
Colon	0.0 nTPM

Macrophages	142.2 nTPM
Pancreas	436.5 nTPM
Kidney	338.1 nTPM
Prostate	183.5 nTPM
Breast	178.9 nTPM
Testis	169.1 nTPM
Lung	160.4 nTPM
Adipose tissue	149.1 nTPM
Ovary	137.7 nTPM
Endometrium	126.4 nTPM
Skeletal muscle	94.6 nTPM
Stomach	41.0 nTPM
Bone marrow	40.0 nTPM
Spleen	37.4 nTPM
Esophagus	26.8 nTPM
PBMC	13.6 nTPM

Paneth cells	191.7 nTPM
Rectum	297.1 nTPM
Small intestine	277.9 nTPM
Colon	0.0 nTPM

Plasma cells	59.3 nTPM
Adipose tissue	87.1 nTPM
Bone marrow	77.4 nTPM
Spleen	73.6 nTPM
Stomach	33.9 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	85.2 nTPM
Lung	170.5 nTPM
Bronchus	0.0 nTPM

Basal prostatic cells	187.1 nTPM
Prostate	187.1 nTPM

Basal squamous epithelial cells	12.5 nTPM
Esophagus	12.5 nTPM

Cholangiocytes	204.5 nTPM
Liver	204.5 nTPM

Collecting duct cells	198.6 nTPM
Kidney	198.6 nTPM

Smooth muscle cells	176.0 nTPM
Pancreas	323.8 nTPM
Heart muscle	317.0 nTPM
Breast	289.8 nTPM
Prostate	247.9 nTPM
Skeletal muscle	234.2 nTPM
Adipose tissue	192.5 nTPM
Ovary	191.6 nTPM
Endometrium	102.1 nTPM
Esophagus	37.2 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	112.9 nTPM
Kidney	286.8 nTPM
Liver	207.9 nTPM
PBMC	202.4 nTPM
Lung	183.8 nTPM
Adipose tissue	172.2 nTPM
Breast	170.3 nTPM
Ovary	164.6 nTPM
Skeletal muscle	135.3 nTPM
Endometrium	110.5 nTPM
Prostate	108.9 nTPM
Bone marrow	52.8 nTPM
Stomach	41.8 nTPM
Spleen	35.7 nTPM
Lymph node	33.2 nTPM
Esophagus	13.1 nTPM
Colon	0.0 nTPM
Skin	0.0 nTPM

Undifferentiated cells	237.6 nTPM
Small intestine	365.1 nTPM
Rectum	347.6 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC