Single cell type - WEE1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WEE1
Gene descriptionⁱ Full gene name according to HGNC.	WEE1 G2 checkpoint kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Glandular and luminal cells, Basal squamous epithelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Glandular and luminal cells, Basal squamous epithelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

WEE1 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ITPKC	Inositol-trisphosphate 3-kinase C	0.7053	44
RNF223	Ring finger protein 223	0.6913	35
MAFF	MAF bZIP transcription factor F	0.6601	44
ALDH3B2	Aldehyde dehydrogenase 3 family member B2	0.6382	61
LRRC8E	Leucine rich repeat containing 8 VRAC subunit E	0.6256	44
ESR1	Estrogen receptor 1	0.6152	44
PARD6B	Par-6 family cell polarity regulator beta	0.6097	44
VMP1	Vacuole membrane protein 1	0.6081	22
VTCN1	V-set domain containing T cell activation inhibitor 1	0.6064	44
AMOTL2	Angiomotin like 2	0.6059	44
RIPK4	Receptor interacting serine/threonine kinase 4	0.6055	44
TESMIN	Testis expressed metallothionein like protein	0.6044	44
YTHDC1	YTH domain containing 1	0.5986	44
ATF3	Activating transcription factor 3	0.5971	7
PER2	Period circadian regulator 2	0.5970	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.2 nTPM
Adipose tissue	28.0 nTPM
Breast	6.4 nTPM

Alveolar cells type 1	51.3 nTPM
Lung	51.3 nTPM

Alveolar cells type 2	33.9 nTPM
Lung	33.9 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	36.8 nTPM
Adipose tissue	160.9 nTPM
Stomach	66.3 nTPM
Spleen	24.6 nTPM
PBMC	21.4 nTPM
Liver	21.2 nTPM
Lymph node	19.4 nTPM
Bone marrow	17.2 nTPM
Colon	14.4 nTPM
Breast	13.4 nTPM
Kidney	9.5 nTPM

Basal squamous epithelial cells	213.9 nTPM
Esophagus	213.9 nTPM

Dendritic cells	11.2 nTPM
Adipose tissue	19.6 nTPM
Breast	13.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	18.7 nTPM
Skin	47.3 nTPM
Endometrium	40.3 nTPM
Breast	34.6 nTPM
Prostate	23.7 nTPM
Skeletal muscle	18.2 nTPM
Heart muscle	17.2 nTPM
Esophagus	16.5 nTPM
Ovary	15.0 nTPM
Liver	13.7 nTPM
Placenta	11.9 nTPM
Testis	8.3 nTPM
Eye	8.1 nTPM
Pancreas	3.9 nTPM
Lung	3.1 nTPM

Enteroendocrine cells	61.1 nTPM
Colon	110.1 nTPM
Rectum	12.1 nTPM

Fibroblasts	39.2 nTPM
Adipose tissue	75.5 nTPM
Lung	61.4 nTPM
Heart muscle	48.9 nTPM
Prostate	43.7 nTPM
Placenta	41.8 nTPM
Skin	36.6 nTPM
Esophagus	28.9 nTPM
Ovary	28.3 nTPM
Skeletal muscle	25.6 nTPM
Stomach	20.8 nTPM
Breast	20.0 nTPM

Intestinal goblet cells	65.6 nTPM
Colon	127.9 nTPM
Small intestine	40.7 nTPM
Rectum	28.3 nTPM

Macrophages	10.0 nTPM
Adipose tissue	35.6 nTPM
Endometrium	32.4 nTPM
Prostate	24.1 nTPM
Skeletal muscle	12.3 nTPM
Esophagus	9.4 nTPM
Lung	8.6 nTPM
Breast	8.0 nTPM
Stomach	5.9 nTPM
Bone marrow	3.7 nTPM
Testis	2.9 nTPM
Pancreas	2.5 nTPM
Kidney	1.5 nTPM
Ovary	1.4 nTPM
Spleen	1.0 nTPM
PBMC	0.0 nTPM

Paneth cells	38.5 nTPM
Colon	75.8 nTPM
Rectum	28.3 nTPM
Small intestine	11.3 nTPM

Plasma cells	17.2 nTPM
Adipose tissue	32.8 nTPM
Esophagus	18.4 nTPM
Bone marrow	16.5 nTPM
Spleen	15.5 nTPM
Stomach	2.8 nTPM

Respiratory ciliated cells	62.6 nTPM
Bronchus	71.2 nTPM
Lung	54.0 nTPM

Cholangiocytes	65.8 nTPM
Liver	65.8 nTPM

Collecting duct cells	42.3 nTPM
Kidney	42.3 nTPM

Cytotrophoblasts	94.8 nTPM
Placenta	94.8 nTPM

Distal enterocytes	54.7 nTPM
Colon	73.8 nTPM
Rectum	35.5 nTPM

Smooth muscle cells	23.7 nTPM
Endometrium	53.8 nTPM
Ovary	40.3 nTPM
Prostate	35.7 nTPM
Heart muscle	24.3 nTPM
Skin	23.4 nTPM
Adipose tissue	22.8 nTPM
Esophagus	15.5 nTPM
Breast	12.8 nTPM
Pancreas	11.2 nTPM
Skeletal muscle	10.8 nTPM
Bronchus	10.4 nTPM

T-cells	19.0 nTPM
Adipose tissue	57.4 nTPM
Skin	43.3 nTPM
Endometrium	41.7 nTPM
Skeletal muscle	36.8 nTPM
Esophagus	19.7 nTPM
Colon	19.0 nTPM
Breast	15.1 nTPM
Liver	14.2 nTPM
Prostate	14.2 nTPM
Kidney	13.1 nTPM
Bone marrow	10.4 nTPM
Spleen	9.1 nTPM
Ovary	8.9 nTPM
PBMC	7.5 nTPM
Stomach	6.1 nTPM
Lymph node	5.2 nTPM
Lung	1.5 nTPM

Undifferentiated cells	55.5 nTPM
Colon	86.4 nTPM
Small intestine	45.1 nTPM
Rectum	34.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC