Single cell type - TERF2IP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TERF2IP
Gene descriptionⁱ Full gene name according to HGNC.	TERF2 interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TERF2IP is part of cluster 6 Erythroid cells - Oxygen transport with confidenceⁱ 1
151 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
VAMP2	Vesicle associated membrane protein 2	0.6187	56
C9orf78	Chromosome 9 open reading frame 78	0.6006	6
PITHD1	PITH domain containing 1	0.5793	6
RBM38	RNA binding motif protein 38	0.5486	24
TMCC2	Transmembrane and coiled-coil domain family 2	0.5366	6
TTC32	Tetratricopeptide repeat domain 32	0.5245	13
EPB42	Erythrocyte membrane protein band 4.2	0.5142	6
YPEL4	Yippee like 4	0.5038	6
HBQ1	Hemoglobin subunit theta 1	0.5036	6
TCEANC	Transcription elongation factor A N-terminal and central domain containing	0.5024	6
EPB41	Erythrocyte membrane protein band 4.1	0.4937	6
RHCE	Rh blood group CcEe antigens	0.4933	6
BPGM	Bisphosphoglycerate mutase	0.4929	6
RAD23A	RAD23 homolog A, nucleotide excision repair protein	0.4927	6
HBA2	Hemoglobin subunit alpha 2	0.4915	6

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	109.1 nTPM
Breast	116.2 nTPM
Adipose tissue	101.9 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	69.3 nTPM
Lung	69.3 nTPM

Astrocytes	30.7 nTPM
Brain	30.7 nTPM

B-cells	160.8 nTPM
Adipose tissue	324.3 nTPM
Lymph node	253.9 nTPM
Stomach	191.7 nTPM
Spleen	165.8 nTPM
Colon	124.6 nTPM
Breast	122.9 nTPM
Bone marrow	116.9 nTPM
PBMC	115.7 nTPM
Kidney	100.0 nTPM
Liver	92.2 nTPM

Basal squamous epithelial cells	163.4 nTPM
Esophagus	163.4 nTPM

Dendritic cells	172.7 nTPM
Adipose tissue	245.3 nTPM
Breast	165.1 nTPM
PBMC	107.6 nTPM

Endothelial cells	102.3 nTPM
Prostate	165.3 nTPM
Skin	135.3 nTPM
Testis	122.4 nTPM
Eye	107.6 nTPM
Ovary	105.4 nTPM
Esophagus	105.0 nTPM
Breast	104.4 nTPM
Skeletal muscle	101.6 nTPM
Lung	99.8 nTPM
Liver	95.4 nTPM
Endometrium	87.7 nTPM
Pancreas	81.1 nTPM
Placenta	61.4 nTPM
Heart muscle	59.3 nTPM

Enteroendocrine cells	97.8 nTPM
Colon	135.0 nTPM
Rectum	60.6 nTPM

Erythroid cells	421.4 nTPM
Liver	759.6 nTPM
Bone marrow	83.2 nTPM

Fibroblasts	115.7 nTPM
Prostate	219.9 nTPM
Skin	133.4 nTPM
Adipose tissue	128.9 nTPM
Breast	119.6 nTPM
Esophagus	117.8 nTPM
Stomach	115.9 nTPM
Lung	115.0 nTPM
Heart muscle	95.0 nTPM
Skeletal muscle	93.4 nTPM
Ovary	70.4 nTPM
Placenta	63.1 nTPM

Intestinal goblet cells	50.1 nTPM
Colon	73.6 nTPM
Rectum	39.5 nTPM
Small intestine	37.2 nTPM

Macrophages	89.3 nTPM
PBMC	190.9 nTPM
Prostate	110.0 nTPM
Adipose tissue	109.5 nTPM
Kidney	107.3 nTPM
Spleen	88.1 nTPM
Bone marrow	86.2 nTPM
Breast	85.6 nTPM
Testis	80.7 nTPM
Endometrium	77.6 nTPM
Lung	74.9 nTPM
Esophagus	70.8 nTPM
Stomach	67.4 nTPM
Pancreas	66.4 nTPM
Skeletal muscle	64.9 nTPM
Ovary	59.8 nTPM

Paneth cells	46.9 nTPM
Small intestine	60.1 nTPM
Rectum	44.5 nTPM
Colon	36.2 nTPM

Plasma cells	162.8 nTPM
Esophagus	240.1 nTPM
Adipose tissue	176.7 nTPM
Stomach	175.2 nTPM
Spleen	116.6 nTPM
Bone marrow	105.4 nTPM

Cholangiocytes	68.6 nTPM
Liver	68.6 nTPM

Collecting duct cells	93.8 nTPM
Kidney	93.8 nTPM

Cone photoreceptor cells	93.8 nTPM
Eye	93.8 nTPM

Cytotrophoblasts	76.8 nTPM
Placenta	76.8 nTPM

Respiratory ciliated cells	66.9 nTPM
Lung	72.9 nTPM
Bronchus	61.0 nTPM

Smooth muscle cells	106.2 nTPM
Prostate	165.4 nTPM
Skin	135.3 nTPM
Esophagus	134.9 nTPM
Pancreas	115.4 nTPM
Skeletal muscle	111.7 nTPM
Breast	108.6 nTPM
Ovary	108.0 nTPM
Adipose tissue	107.8 nTPM
Endometrium	81.1 nTPM
Heart muscle	76.2 nTPM
Bronchus	23.5 nTPM

T-cells	215.0 nTPM
Adipose tissue	394.4 nTPM
Skin	298.4 nTPM
Prostate	250.9 nTPM
Esophagus	242.3 nTPM
Colon	237.1 nTPM
Lymph node	227.0 nTPM
Stomach	221.4 nTPM
Ovary	220.2 nTPM
Liver	204.3 nTPM
Skeletal muscle	199.0 nTPM
Spleen	198.2 nTPM
Kidney	193.7 nTPM
Breast	193.4 nTPM
Bone marrow	168.5 nTPM
Endometrium	158.5 nTPM
PBMC	147.7 nTPM
Lung	100.2 nTPM

Undifferentiated cells	32.2 nTPM
Small intestine	35.2 nTPM
Rectum	31.0 nTPM
Colon	30.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC