Single cell type - AKTIP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AKTIP
Gene descriptionⁱ Full gene name according to HGNC.	AKT interacting protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AKTIP is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HERPUD2	HERPUD family member 2	0.5470	31
ATMIN	ATM interactor	0.5470	34
P2RY2	Purinergic receptor P2Y2	0.5387	47
CCSER2	Coiled-coil serine rich protein 2	0.4821	31
SBDS	SBDS ribosome maturation factor	0.4709	31
PBXIP1	PBX homeobox interacting protein 1	0.4648	24
OTOG	Otogelin	0.4602	31
CROT	Carnitine O-octanoyltransferase	0.4509	47
TMEM266	Transmembrane protein 266	0.4457	47
RAB33B	RAB33B, member RAS oncogene family	0.4379	31
LMNTD2	Lamin tail domain containing 2	0.4370	31
TCAF2	TRPM8 channel associated factor 2	0.4308	58
SLC16A5	Solute carrier family 16 member 5	0.4287	45
TRPV6	Transient receptor potential cation channel subfamily V member 6	0.4274	1
IGDCC3	Immunoglobulin superfamily DCC subclass member 3	0.4269	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	41.9 nTPM
Adipose tissue	62.2 nTPM
Breast	21.6 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	15.4 nTPM
Lung	15.4 nTPM

Astrocytes	11.8 nTPM
Brain	11.8 nTPM

B-cells	9.3 nTPM
PBMC	18.6 nTPM
Liver	11.9 nTPM
Stomach	11.8 nTPM
Lymph node	11.3 nTPM
Spleen	10.4 nTPM
Adipose tissue	10.0 nTPM
Breast	6.6 nTPM
Bone marrow	5.7 nTPM
Kidney	4.8 nTPM
Colon	1.6 nTPM

Dendritic cells	13.6 nTPM
Breast	22.9 nTPM
Adipose tissue	17.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	22.2 nTPM
Skeletal muscle	39.1 nTPM
Pancreas	38.6 nTPM
Lung	28.1 nTPM
Testis	26.6 nTPM
Ovary	26.4 nTPM
Breast	24.4 nTPM
Skin	24.3 nTPM
Heart muscle	17.8 nTPM
Eye	17.0 nTPM
Placenta	17.0 nTPM
Liver	13.7 nTPM
Prostate	13.0 nTPM
Endometrium	12.8 nTPM
Esophagus	12.4 nTPM

Fibroblasts	16.4 nTPM
Skeletal muscle	22.4 nTPM
Skin	19.6 nTPM
Lung	19.0 nTPM
Adipose tissue	18.9 nTPM
Breast	17.5 nTPM
Placenta	17.4 nTPM
Esophagus	16.7 nTPM
Stomach	16.3 nTPM
Prostate	12.4 nTPM
Heart muscle	10.7 nTPM
Ovary	9.2 nTPM

Intestinal goblet cells	6.5 nTPM
Small intestine	7.6 nTPM
Rectum	7.5 nTPM
Colon	4.3 nTPM

Macrophages	6.2 nTPM
Breast	10.8 nTPM
Pancreas	10.2 nTPM
Lung	10.0 nTPM
Kidney	9.9 nTPM
Testis	8.8 nTPM
Skeletal muscle	7.8 nTPM
Spleen	7.2 nTPM
Ovary	6.0 nTPM
Endometrium	5.1 nTPM
Bone marrow	5.0 nTPM
Esophagus	4.8 nTPM
Adipose tissue	4.7 nTPM
Prostate	3.4 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	6.0 nTPM
Rectum	10.9 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM

Plasma cells	12.2 nTPM
Adipose tissue	24.5 nTPM
Stomach	15.7 nTPM
Spleen	9.7 nTPM
Esophagus	6.1 nTPM
Bone marrow	5.0 nTPM

Respiratory ciliated cells	22.0 nTPM
Bronchus	22.1 nTPM
Lung	21.9 nTPM

Smooth muscle cells	22.2 nTPM
Prostate	34.0 nTPM
Skin	33.9 nTPM
Breast	27.1 nTPM
Pancreas	24.6 nTPM
Skeletal muscle	24.6 nTPM
Esophagus	21.7 nTPM
Heart muscle	20.9 nTPM
Bronchus	17.1 nTPM
Adipose tissue	13.9 nTPM
Ovary	13.8 nTPM
Endometrium	12.8 nTPM

T-cells	28.7 nTPM
Adipose tissue	55.0 nTPM
PBMC	46.1 nTPM
Kidney	43.1 nTPM
Skin	37.3 nTPM
Breast	35.8 nTPM
Ovary	33.3 nTPM
Stomach	30.4 nTPM
Spleen	29.2 nTPM
Bone marrow	27.4 nTPM
Skeletal muscle	26.8 nTPM
Lymph node	25.5 nTPM
Esophagus	19.7 nTPM
Colon	18.1 nTPM
Endometrium	18.1 nTPM
Liver	17.3 nTPM
Lung	15.2 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	7.0 nTPM
Skin	7.0 nTPM

Basal prostatic cells	15.1 nTPM
Prostate	15.1 nTPM

Basal respiratory cells	29.0 nTPM
Bronchus	29.0 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Undifferentiated cells	11.5 nTPM
Rectum	12.1 nTPM
Small intestine	11.3 nTPM
Colon	11.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC