Single cell type - CDK2AP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CDK2AP2
Gene descriptionⁱ Full gene name according to HGNC.	Cyclin dependent kinase 2 associated protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CDK2AP2 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SEPHS2	Selenophosphate synthetase 2	0.6675	7
COA3	Cytochrome c oxidase assembly factor 3	0.5960	67
MIF	Macrophage migration inhibitory factor	0.5265	67
C12orf75	Chromosome 12 open reading frame 75	0.5247	67
NDUFB11	NADH:ubiquinone oxidoreductase subunit B11	0.5044	39
FKBP2	FKBP prolyl isomerase 2	0.5024	55
ADAT3	Adenosine deaminase tRNA specific 3	0.4892	61
SIGIRR	Single Ig and TIR domain containing	0.4803	67
DBI	Diazepam binding inhibitor, acyl-CoA binding protein	0.4782	39
TIMM17B	Translocase of inner mitochondrial membrane 17B	0.4681	39
UBL5	Ubiquitin like 5	0.4674	39
DDIT3	DNA damage inducible transcript 3	0.4615	7
RGS14	Regulator of G protein signaling 14	0.4540	61
CALR	Calreticulin	0.4391	38
SPX	Spexin hormone	0.4330	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	54.6 nTPM
Breast	70.4 nTPM
Adipose tissue	38.8 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	86.2 nTPM
Lung	86.2 nTPM

Astrocytes	4.2 nTPM
Brain	4.2 nTPM

B-cells	112.0 nTPM
Liver	204.1 nTPM
Breast	193.8 nTPM
Lymph node	146.6 nTPM
Kidney	123.8 nTPM
Colon	108.6 nTPM
Spleen	92.0 nTPM
PBMC	72.9 nTPM
Stomach	64.1 nTPM
Bone marrow	60.5 nTPM
Adipose tissue	53.1 nTPM

Basal squamous epithelial cells	186.1 nTPM
Esophagus	186.1 nTPM

Dendritic cells	206.5 nTPM
Breast	249.3 nTPM
PBMC	215.2 nTPM
Adipose tissue	154.9 nTPM

Endothelial cells	56.8 nTPM
Eye	104.4 nTPM
Breast	83.3 nTPM
Placenta	74.4 nTPM
Esophagus	72.8 nTPM
Skin	69.8 nTPM
Heart muscle	55.1 nTPM
Ovary	52.2 nTPM
Liver	51.3 nTPM
Pancreas	50.2 nTPM
Endometrium	47.7 nTPM
Prostate	43.5 nTPM
Skeletal muscle	35.1 nTPM
Testis	33.5 nTPM
Lung	21.8 nTPM

Enteroendocrine cells	102.8 nTPM
Colon	174.1 nTPM
Rectum	31.6 nTPM

Fibroblasts	49.0 nTPM
Lung	121.7 nTPM
Heart muscle	80.4 nTPM
Prostate	71.8 nTPM
Placenta	52.6 nTPM
Esophagus	41.7 nTPM
Skin	38.6 nTPM
Stomach	35.6 nTPM
Breast	34.2 nTPM
Ovary	30.0 nTPM
Adipose tissue	17.7 nTPM
Skeletal muscle	14.5 nTPM

Intestinal goblet cells	151.1 nTPM
Colon	309.5 nTPM
Small intestine	84.7 nTPM
Rectum	59.0 nTPM

Macrophages	71.5 nTPM
Esophagus	125.9 nTPM
Breast	124.0 nTPM
Kidney	114.9 nTPM
Prostate	106.5 nTPM
Endometrium	97.7 nTPM
Adipose tissue	76.2 nTPM
Pancreas	74.0 nTPM
Bone marrow	58.8 nTPM
Spleen	57.0 nTPM
Lung	52.0 nTPM
Ovary	45.3 nTPM
Skeletal muscle	43.5 nTPM
Testis	41.8 nTPM
PBMC	40.9 nTPM
Stomach	14.7 nTPM

Paneth cells	158.5 nTPM
Colon	329.4 nTPM
Small intestine	97.6 nTPM
Rectum	48.6 nTPM

Plasma cells	240.8 nTPM
Esophagus	455.8 nTPM
Stomach	263.1 nTPM
Spleen	252.9 nTPM
Bone marrow	141.8 nTPM
Adipose tissue	90.4 nTPM

Respiratory ciliated cells	64.6 nTPM
Lung	74.4 nTPM
Bronchus	54.8 nTPM

Cholangiocytes	88.6 nTPM
Liver	88.6 nTPM

Collecting duct cells	117.7 nTPM
Kidney	117.7 nTPM

Cone photoreceptor cells	31.3 nTPM
Eye	31.3 nTPM

Cytotrophoblasts	94.9 nTPM
Placenta	94.9 nTPM

Smooth muscle cells	76.2 nTPM
Skin	125.6 nTPM
Esophagus	117.8 nTPM
Heart muscle	102.1 nTPM
Pancreas	92.2 nTPM
Breast	86.8 nTPM
Prostate	81.6 nTPM
Ovary	81.0 nTPM
Endometrium	45.2 nTPM
Adipose tissue	40.0 nTPM
Skeletal muscle	34.4 nTPM
Bronchus	31.9 nTPM

T-cells	131.4 nTPM
Breast	203.1 nTPM
Skin	189.7 nTPM
Stomach	181.8 nTPM
Colon	177.2 nTPM
Esophagus	176.9 nTPM
Lymph node	150.9 nTPM
Kidney	142.3 nTPM
Lung	133.7 nTPM
Spleen	127.2 nTPM
Adipose tissue	115.1 nTPM
Bone marrow	103.0 nTPM
Liver	100.5 nTPM
Prostate	94.7 nTPM
Endometrium	91.7 nTPM
Skeletal muscle	82.8 nTPM
Ovary	82.3 nTPM
PBMC	80.4 nTPM

Undifferentiated cells	123.2 nTPM
Colon	208.7 nTPM
Small intestine	93.2 nTPM
Rectum	67.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC