Single cell type - SRRM2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SRRM2
Gene descriptionⁱ Full gene name according to HGNC.	Serine/arginine repetitive matrix 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SRRM2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RBM25	RNA binding motif protein 25	0.6664	52
PNN	Pinin, desmosome associated protein	0.6281	52
SREK1	Splicing regulatory glutamic acid and lysine rich protein 1	0.6173	52
HMGXB3	HMG-box containing 3	0.6017	52
ATXN7L3B	Ataxin 7 like 3B	0.5974	10
RBM39	RNA binding motif protein 39	0.5864	52
HOXA6	Homeobox A6	0.5667	36
KIN	Kin17 DNA and RNA binding protein	0.5642	10
TRA2B	Transformer 2 beta homolog	0.5524	7
AC001226.2	Novel protein	0.5505	44
KMT2B	Lysine methyltransferase 2B	0.5502	52
CDK12	Cyclin dependent kinase 12	0.5370	10
NOM1	Nucleolar protein with MIF4G domain 1	0.5268	39
DDX39B	DExD-box helicase 39B	0.5249	52
SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein	0.5172	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	286.4 nTPM
Adipose tissue	292.0 nTPM
Breast	280.6 nTPM

Alveolar cells type 1	141.1 nTPM
Lung	141.1 nTPM

Alveolar cells type 2	232.4 nTPM
Lung	232.4 nTPM

Astrocytes	134.8 nTPM
Brain	134.8 nTPM

B-cells	221.3 nTPM
Adipose tissue	448.6 nTPM
Breast	341.1 nTPM
Liver	241.9 nTPM
Lymph node	207.9 nTPM
Stomach	187.2 nTPM
Bone marrow	167.6 nTPM
PBMC	167.0 nTPM
Spleen	162.0 nTPM
Colon	161.3 nTPM
Kidney	128.5 nTPM

Basal squamous epithelial cells	178.2 nTPM
Esophagus	178.2 nTPM

Dendritic cells	289.0 nTPM
Adipose tissue	375.4 nTPM
Breast	296.3 nTPM
PBMC	195.3 nTPM

Endothelial cells	230.3 nTPM
Prostate	421.0 nTPM
Skeletal muscle	317.6 nTPM
Eye	276.7 nTPM
Endometrium	272.4 nTPM
Breast	265.3 nTPM
Ovary	237.7 nTPM
Skin	232.2 nTPM
Liver	208.2 nTPM
Testis	204.2 nTPM
Esophagus	198.4 nTPM
Placenta	171.1 nTPM
Pancreas	169.9 nTPM
Heart muscle	127.3 nTPM
Lung	121.6 nTPM

Enteroendocrine cells	189.6 nTPM
Colon	223.8 nTPM
Rectum	155.3 nTPM

Erythroid cells	191.6 nTPM
Liver	192.5 nTPM
Bone marrow	190.8 nTPM

Fibroblasts	235.0 nTPM
Prostate	494.9 nTPM
Breast	307.5 nTPM
Adipose tissue	303.1 nTPM
Skeletal muscle	259.4 nTPM
Ovary	215.9 nTPM
Skin	204.6 nTPM
Esophagus	175.0 nTPM
Lung	167.5 nTPM
Stomach	166.3 nTPM
Placenta	155.4 nTPM
Heart muscle	135.6 nTPM

Intestinal goblet cells	245.2 nTPM
Colon	368.7 nTPM
Small intestine	195.7 nTPM
Rectum	171.1 nTPM

Macrophages	208.1 nTPM
Adipose tissue	345.0 nTPM
Endometrium	340.4 nTPM
Breast	289.1 nTPM
Skeletal muscle	281.6 nTPM
Prostate	240.8 nTPM
Ovary	240.6 nTPM
Kidney	183.0 nTPM
Stomach	181.7 nTPM
Bone marrow	181.2 nTPM
Esophagus	165.3 nTPM
Spleen	160.7 nTPM
Lung	159.4 nTPM
Pancreas	155.7 nTPM
Testis	142.9 nTPM
PBMC	54.6 nTPM

Paneth cells	188.4 nTPM
Colon	276.7 nTPM
Rectum	164.6 nTPM
Small intestine	123.9 nTPM

Plasma cells	262.3 nTPM
Adipose tissue	507.7 nTPM
Bone marrow	243.9 nTPM
Spleen	209.7 nTPM
Stomach	196.0 nTPM
Esophagus	154.1 nTPM

Cholangiocytes	147.3 nTPM
Liver	147.3 nTPM

Collecting duct cells	167.3 nTPM
Kidney	167.3 nTPM

Cone photoreceptor cells	291.9 nTPM
Eye	291.9 nTPM

Cytotrophoblasts	179.3 nTPM
Placenta	179.3 nTPM

Respiratory ciliated cells	146.6 nTPM
Bronchus	185.3 nTPM
Lung	107.8 nTPM

Smooth muscle cells	391.0 nTPM
Bronchus	1619.5 nTPM
Prostate	406.3 nTPM
Skeletal muscle	370.2 nTPM
Endometrium	351.8 nTPM
Adipose tissue	297.5 nTPM
Breast	296.5 nTPM
Ovary	267.3 nTPM
Skin	252.8 nTPM
Pancreas	182.0 nTPM
Esophagus	145.7 nTPM
Heart muscle	111.3 nTPM

T-cells	237.5 nTPM
Endometrium	455.9 nTPM
Skeletal muscle	436.3 nTPM
Adipose tissue	370.3 nTPM
Prostate	340.9 nTPM
Breast	313.5 nTPM
Ovary	311.4 nTPM
Colon	193.9 nTPM
Lung	186.8 nTPM
PBMC	179.0 nTPM
Lymph node	178.0 nTPM
Kidney	176.6 nTPM
Esophagus	170.3 nTPM
Bone marrow	158.1 nTPM
Liver	153.6 nTPM
Skin	143.3 nTPM
Spleen	141.2 nTPM
Stomach	128.3 nTPM

Undifferentiated cells	236.5 nTPM
Colon	348.3 nTPM
Small intestine	188.1 nTPM
Rectum	173.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC