Single cell type - TRAPPC11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRAPPC11
Gene descriptionⁱ Full gene name according to HGNC.	Trafficking protein particle complex 11
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Flagellum & Golgi organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRAPPC11 is part of cluster 23 Spermatids - Flagellum & Golgi organization with confidenceⁱ 1
311 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KLHL12	Kelch like family member 12	0.6367	23
CATSPER3	Cation channel sperm associated 3	0.6147	23
MTG2	Mitochondrial ribosome associated GTPase 2	0.5795	23
IPO8	Importin 8	0.5768	23
METTL6	Methyltransferase like 6	0.5674	23
POLR1B	RNA polymerase I subunit B	0.5622	23
USP50	Ubiquitin specific peptidase 50	0.5547	23
TRUB1	TruB pseudouridine synthase family member 1	0.5480	23
PSMB11	Proteasome subunit beta 11	0.5444	23
CNBD1	Cyclic nucleotide binding domain containing 1	0.5382	23
PRY	PTPN13 like Y-linked	0.5330	23
TIGD4	Tigger transposable element derived 4	0.5306	23
C4orf51	Chromosome 4 open reading frame 51	0.5291	23
TMEM89	Transmembrane protein 89	0.5251	23
ANTXRL	ANTXR like	0.5247	23

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	9.5 nTPM
Adipose tissue	11.2 nTPM
Breast	7.8 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	14.5 nTPM
Lung	14.5 nTPM

Astrocytes	33.0 nTPM
Brain	33.0 nTPM

B-cells	12.3 nTPM
Bone marrow	22.1 nTPM
Stomach	19.1 nTPM
Spleen	14.9 nTPM
Lymph node	14.5 nTPM
PBMC	14.3 nTPM
Adipose tissue	13.0 nTPM
Liver	8.0 nTPM
Breast	6.6 nTPM
Colon	6.4 nTPM
Kidney	4.8 nTPM

Dendritic cells	10.0 nTPM
PBMC	12.0 nTPM
Adipose tissue	11.8 nTPM
Breast	6.2 nTPM

Endothelial cells	9.1 nTPM
Heart muscle	15.7 nTPM
Ovary	14.9 nTPM
Endometrium	13.1 nTPM
Testis	12.8 nTPM
Eye	11.3 nTPM
Liver	11.0 nTPM
Esophagus	10.9 nTPM
Skeletal muscle	9.9 nTPM
Lung	9.3 nTPM
Placenta	6.2 nTPM
Breast	5.8 nTPM
Prostate	3.3 nTPM
Skin	2.8 nTPM
Pancreas	0.0 nTPM

Fibroblasts	12.0 nTPM
Heart muscle	24.7 nTPM
Ovary	18.1 nTPM
Adipose tissue	15.8 nTPM
Skeletal muscle	14.3 nTPM
Esophagus	13.6 nTPM
Lung	8.9 nTPM
Stomach	8.9 nTPM
Placenta	8.5 nTPM
Breast	7.5 nTPM
Prostate	5.7 nTPM
Skin	5.5 nTPM

Intestinal goblet cells	7.2 nTPM
Rectum	11.8 nTPM
Small intestine	6.1 nTPM
Colon	3.6 nTPM

Macrophages	16.1 nTPM
Bone marrow	37.5 nTPM
Spleen	30.0 nTPM
Ovary	21.3 nTPM
Stomach	20.5 nTPM
Lung	20.0 nTPM
Testis	19.7 nTPM
Skeletal muscle	17.0 nTPM
Adipose tissue	15.9 nTPM
Endometrium	11.6 nTPM
Prostate	11.5 nTPM
Esophagus	11.0 nTPM
Kidney	10.6 nTPM
Pancreas	7.7 nTPM
Breast	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	7.1 nTPM
Rectum	11.1 nTPM
Colon	6.5 nTPM
Small intestine	3.7 nTPM

Plasma cells	10.6 nTPM
Stomach	14.0 nTPM
Spleen	12.7 nTPM
Adipose tissue	10.3 nTPM
Bone marrow	9.9 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	12.9 nTPM
Lung	16.0 nTPM
Bronchus	9.7 nTPM

Smooth muscle cells	8.6 nTPM
Esophagus	15.5 nTPM
Adipose tissue	12.5 nTPM
Ovary	11.4 nTPM
Skeletal muscle	10.3 nTPM
Endometrium	8.9 nTPM
Bronchus	7.5 nTPM
Heart muscle	6.9 nTPM
Breast	6.5 nTPM
Pancreas	5.5 nTPM
Prostate	5.3 nTPM
Skin	4.6 nTPM

T-cells	9.4 nTPM
Bone marrow	18.1 nTPM
Lung	15.2 nTPM
Lymph node	14.3 nTPM
Spleen	12.4 nTPM
Stomach	11.8 nTPM
Liver	11.6 nTPM
PBMC	11.6 nTPM
Skeletal muscle	10.7 nTPM
Adipose tissue	10.0 nTPM
Colon	8.5 nTPM
Endometrium	8.0 nTPM
Kidney	6.9 nTPM
Esophagus	6.6 nTPM
Breast	4.9 nTPM
Skin	4.6 nTPM
Ovary	4.5 nTPM
Prostate	0.0 nTPM

Basal prostatic cells	3.1 nTPM
Prostate	3.1 nTPM

Basal respiratory cells	7.4 nTPM
Bronchus	7.4 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cone photoreceptor cells	8.4 nTPM
Eye	8.4 nTPM

Undifferentiated cells	7.9 nTPM
Rectum	9.7 nTPM
Small intestine	9.6 nTPM
Colon	4.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC