Single cell type - ADAM9 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADAM9
Gene descriptionⁱ Full gene name according to HGNC.	ADAM metallopeptidase domain 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Pancreatic endocrine cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (classical monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ADAM9 is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MACC1	MET transcriptional regulator MACC1	0.7202	22
SPOCD1	SPOC domain containing 1	0.6302	22
ITGAV	Integrin subunit alpha V	0.6210	44
ITGA2	Integrin subunit alpha 2	0.6018	22
CD63	CD63 molecule	0.5877	16
CST6	Cystatin E/M	0.5831	49
CDCP1	CUB domain containing protein 1	0.5821	26
AC008687.4	Novel protein	0.5807	16
TMEM51	Transmembrane protein 51	0.5744	1
ZSWIM4	Zinc finger SWIM-type containing 4	0.5712	44
LCE3D	Late cornified envelope 3D	0.5695	16
LAMC2	Laminin subunit gamma 2	0.5588	16
LCN2	Lipocalin 2	0.5574	26
MUC1	Mucin 1, cell surface associated	0.5549	16
TGFA	Transforming growth factor alpha	0.5495	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.4 nTPM
Adipose tissue	16.5 nTPM
Breast	12.3 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	37.0 nTPM
Lung	37.0 nTPM

Astrocytes	16.0 nTPM
Brain	16.0 nTPM

B-cells	3.8 nTPM
Colon	14.4 nTPM
Liver	8.1 nTPM
Adipose tissue	5.0 nTPM
Stomach	2.7 nTPM
Lymph node	2.6 nTPM
Breast	2.6 nTPM
Bone marrow	1.7 nTPM
Spleen	1.0 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM

Dendritic cells	8.9 nTPM
PBMC	12.0 nTPM
Adipose tissue	8.1 nTPM
Breast	6.5 nTPM

Endothelial cells	20.5 nTPM
Ovary	38.9 nTPM
Heart muscle	36.3 nTPM
Lung	31.2 nTPM
Skin	26.1 nTPM
Endometrium	24.6 nTPM
Prostate	23.5 nTPM
Liver	18.3 nTPM
Eye	16.2 nTPM
Placenta	15.9 nTPM
Testis	15.7 nTPM
Skeletal muscle	13.7 nTPM
Breast	13.4 nTPM
Esophagus	9.7 nTPM
Pancreas	3.9 nTPM

Fibroblasts	42.0 nTPM
Esophagus	60.4 nTPM
Adipose tissue	58.4 nTPM
Skin	55.9 nTPM
Skeletal muscle	53.8 nTPM
Placenta	53.6 nTPM
Heart muscle	46.7 nTPM
Stomach	43.0 nTPM
Lung	33.5 nTPM
Prostate	23.4 nTPM
Breast	17.7 nTPM
Ovary	15.3 nTPM

Intestinal goblet cells	32.2 nTPM
Colon	36.4 nTPM
Rectum	32.3 nTPM
Small intestine	27.8 nTPM

Macrophages	54.7 nTPM
Ovary	94.1 nTPM
Pancreas	84.2 nTPM
Esophagus	81.8 nTPM
Stomach	70.3 nTPM
Prostate	68.8 nTPM
Adipose tissue	63.4 nTPM
Spleen	57.0 nTPM
Skeletal muscle	51.5 nTPM
Testis	48.7 nTPM
Bone marrow	47.5 nTPM
Endometrium	44.7 nTPM
Lung	40.0 nTPM
Kidney	28.7 nTPM
Breast	25.9 nTPM
PBMC	13.6 nTPM

Paneth cells	30.6 nTPM
Rectum	35.7 nTPM
Colon	29.6 nTPM
Small intestine	26.3 nTPM

Plasma cells	5.2 nTPM
Spleen	6.7 nTPM
Esophagus	6.1 nTPM
Adipose tissue	5.8 nTPM
Bone marrow	5.0 nTPM
Stomach	2.6 nTPM

Respiratory ciliated cells	51.9 nTPM
Bronchus	87.8 nTPM
Lung	16.0 nTPM

Smooth muscle cells	31.9 nTPM
Pancreas	42.8 nTPM
Endometrium	40.1 nTPM
Heart muscle	37.4 nTPM
Ovary	36.0 nTPM
Bronchus	31.9 nTPM
Skin	31.1 nTPM
Adipose tissue	30.9 nTPM
Skeletal muscle	28.4 nTPM
Prostate	28.2 nTPM
Esophagus	24.8 nTPM
Breast	19.9 nTPM

T-cells	5.6 nTPM
Esophagus	19.7 nTPM
Lung	12.2 nTPM
Endometrium	12.1 nTPM
Colon	7.1 nTPM
Skeletal muscle	5.4 nTPM
Kidney	4.7 nTPM
Prostate	4.7 nTPM
Skin	4.6 nTPM
Ovary	4.5 nTPM
Adipose tissue	4.2 nTPM
Breast	3.4 nTPM
Stomach	3.1 nTPM
Lymph node	2.5 nTPM
Bone marrow	2.5 nTPM
Spleen	1.9 nTPM
Liver	1.7 nTPM
PBMC	0.9 nTPM

Basal keratinocytes	35.9 nTPM
Skin	35.9 nTPM

Basal prostatic cells	66.6 nTPM
Prostate	66.6 nTPM

Basal respiratory cells	78.3 nTPM
Bronchus	78.3 nTPM

Basal squamous epithelial cells	26.7 nTPM
Esophagus	26.7 nTPM

Undifferentiated cells	32.7 nTPM
Rectum	37.0 nTPM
Colon	36.1 nTPM
Small intestine	25.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC