Single cell type - RNF181 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNF181
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger protein 181
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RNF181 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LSM3	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	0.6604	67
MTIF3	Mitochondrial translational initiation factor 3	0.6061	39
STK19	Serine/threonine kinase 19	0.6053	67
MT1H	Metallothionein 1H	0.5951	67
ACY3	Aminoacylase 3	0.5727	67
TPMT	Thiopurine S-methyltransferase	0.5704	67
MT1F	Metallothionein 1F	0.5667	67
TXNDC17	Thioredoxin domain containing 17	0.5637	26
MT1G	Metallothionein 1G	0.5593	67
C4orf3	Chromosome 4 open reading frame 3	0.5565	26
CHCHD5	Coiled-coil-helix-coiled-coil-helix domain containing 5	0.5560	39
INSC	INSC spindle orientation adaptor protein	0.5532	67
ATP5MPL	ATP synthase membrane subunit 6.8PL	0.5516	7
LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	0.5513	67
BPI	Bactericidal permeability increasing protein	0.5508	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	89.3 nTPM
Breast	98.0 nTPM
Adipose tissue	80.7 nTPM

Alveolar cells type 1	147.4 nTPM
Lung	147.4 nTPM

Alveolar cells type 2	104.8 nTPM
Lung	104.8 nTPM

Astrocytes	7.8 nTPM
Brain	7.8 nTPM

B-cells	89.3 nTPM
Kidney	176.2 nTPM
Liver	167.6 nTPM
PBMC	87.1 nTPM
Breast	85.6 nTPM
Bone marrow	72.7 nTPM
Colon	70.3 nTPM
Spleen	68.2 nTPM
Stomach	65.4 nTPM
Adipose tissue	58.7 nTPM
Lymph node	41.0 nTPM

Dendritic cells	104.2 nTPM
PBMC	143.4 nTPM
Adipose tissue	87.5 nTPM
Breast	81.6 nTPM

Endothelial cells	102.8 nTPM
Pancreas	212.4 nTPM
Placenta	170.5 nTPM
Prostate	129.2 nTPM
Skin	120.4 nTPM
Testis	113.8 nTPM
Liver	103.7 nTPM
Heart muscle	95.8 nTPM
Breast	90.5 nTPM
Ovary	79.2 nTPM
Lung	74.8 nTPM
Esophagus	72.1 nTPM
Skeletal muscle	65.0 nTPM
Eye	56.7 nTPM
Endometrium	55.1 nTPM

Fibroblasts	113.7 nTPM
Placenta	256.7 nTPM
Prostate	160.5 nTPM
Heart muscle	133.8 nTPM
Skin	130.8 nTPM
Adipose tissue	97.2 nTPM
Lung	93.8 nTPM
Stomach	81.7 nTPM
Breast	80.0 nTPM
Esophagus	73.8 nTPM
Ovary	72.0 nTPM
Skeletal muscle	70.3 nTPM

Intestinal goblet cells	138.4 nTPM
Colon	173.7 nTPM
Small intestine	135.0 nTPM
Rectum	106.5 nTPM

Macrophages	147.6 nTPM
Kidney	367.6 nTPM
Pancreas	293.6 nTPM
Lung	175.9 nTPM
Testis	174.3 nTPM
Prostate	149.0 nTPM
Bone marrow	145.0 nTPM
Ovary	139.7 nTPM
Stomach	117.2 nTPM
Endometrium	112.4 nTPM
Adipose tissue	103.1 nTPM
Breast	98.7 nTPM
Esophagus	97.6 nTPM
Spleen	97.4 nTPM
Skeletal muscle	87.5 nTPM
PBMC	54.6 nTPM

Paneth cells	201.5 nTPM
Colon	289.8 nTPM
Small intestine	187.7 nTPM
Rectum	127.0 nTPM

Plasma cells	113.8 nTPM
Stomach	153.2 nTPM
Esophagus	141.5 nTPM
Spleen	127.2 nTPM
Bone marrow	87.4 nTPM
Adipose tissue	59.4 nTPM

Respiratory ciliated cells	141.7 nTPM
Bronchus	187.2 nTPM
Lung	96.2 nTPM

Smooth muscle cells	108.8 nTPM
Pancreas	243.8 nTPM
Heart muscle	163.8 nTPM
Skin	125.8 nTPM
Prostate	122.5 nTPM
Esophagus	103.9 nTPM
Breast	97.9 nTPM
Ovary	81.5 nTPM
Skeletal muscle	72.9 nTPM
Adipose tissue	72.8 nTPM
Bronchus	64.7 nTPM
Endometrium	46.9 nTPM

T-cells	86.7 nTPM
Kidney	160.9 nTPM
Skin	123.8 nTPM
Prostate	123.0 nTPM
Esophagus	117.9 nTPM
Liver	97.7 nTPM
Lung	97.2 nTPM
Colon	89.8 nTPM
PBMC	85.2 nTPM
Adipose tissue	78.4 nTPM
Bone marrow	75.8 nTPM
Stomach	75.0 nTPM
Spleen	71.5 nTPM
Ovary	64.5 nTPM
Breast	63.1 nTPM
Endometrium	57.8 nTPM
Skeletal muscle	46.8 nTPM
Lymph node	45.1 nTPM

Basal keratinocytes	116.9 nTPM
Skin	116.9 nTPM

Basal prostatic cells	102.5 nTPM
Prostate	102.5 nTPM

Basal respiratory cells	343.7 nTPM
Bronchus	343.7 nTPM

Basal squamous epithelial cells	75.7 nTPM
Esophagus	75.7 nTPM

Undifferentiated cells	102.0 nTPM
Colon	109.0 nTPM
Small intestine	102.4 nTPM
Rectum	94.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC