Single cell type - SLC35G2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC35G2
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 35 member G2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Adipocytes & Endothelial cells - Angiogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Astrocytes, Inhibitory neurons, Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (memory CD8 T-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ hTERT+)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Astrocytes, Inhibitory neurons, Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC35G2 is part of cluster 14 Adipocytes & Endothelial cells - Angiogenesis with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NOS3	Nitric oxide synthase 3	0.5366	14
SMAD1	SMAD family member 1	0.5200	14
CCDC178	Coiled-coil domain containing 178	0.5178	66
PDE2A	Phosphodiesterase 2A	0.5078	14
THSD1	Thrombospondin type 1 domain containing 1	0.5032	14
P4HA3	Prolyl 4-hydroxylase subunit alpha 3	0.5000	23
NUDCD1	NudC domain containing 1	0.4972	23
CPNE8	Copine 8	0.4684	21
CXorf58	Chromosome X open reading frame 58	0.4666	13
ERG	ETS transcription factor ERG	0.4636	14
IQCH	IQ motif containing H	0.4599	49
AGBL3	ATP/GTP binding protein like 3	0.4592	23
RHOJ	Ras homolog family member J	0.4562	14
TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1	0.4556	14
IL33	Interleukin 33	0.4539	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	7.0 nTPM
Lung	7.0 nTPM

B-cells	2.5 nTPM
Kidney	9.5 nTPM
Colon	4.8 nTPM
PBMC	4.3 nTPM
Breast	4.0 nTPM
Liver	1.3 nTPM
Bone marrow	0.8 nTPM
Lymph node	0.3 nTPM
Spleen	0.3 nTPM
Adipose tissue	0.0 nTPM
Stomach	0.0 nTPM

Basal keratinocytes	3.3 nTPM
Skin	3.3 nTPM

Basal prostatic cells	4.9 nTPM
Prostate	4.9 nTPM

Dendritic cells	2.7 nTPM
PBMC	4.0 nTPM
Breast	2.5 nTPM
Adipose tissue	1.5 nTPM

Endothelial cells	30.6 nTPM
Testis	56.8 nTPM
Esophagus	50.5 nTPM
Pancreas	50.2 nTPM
Prostate	48.5 nTPM
Skin	34.6 nTPM
Ovary	28.9 nTPM
Heart muscle	27.2 nTPM
Skeletal muscle	23.8 nTPM
Placenta	23.3 nTPM
Liver	22.9 nTPM
Breast	20.7 nTPM
Lung	18.7 nTPM
Eye	11.3 nTPM
Endometrium	10.3 nTPM

Fibroblasts	12.4 nTPM
Stomach	22.3 nTPM
Heart muscle	20.6 nTPM
Prostate	18.8 nTPM
Skin	14.5 nTPM
Adipose tissue	13.8 nTPM
Lung	13.4 nTPM
Skeletal muscle	10.6 nTPM
Esophagus	8.7 nTPM
Breast	8.6 nTPM
Ovary	2.8 nTPM
Placenta	2.5 nTPM

Intestinal goblet cells	1.0 nTPM
Small intestine	1.8 nTPM
Colon	0.7 nTPM
Rectum	0.4 nTPM

Macrophages	2.1 nTPM
Lung	12.5 nTPM
Kidney	4.6 nTPM
Testis	2.9 nTPM
Pancreas	2.5 nTPM
Prostate	2.2 nTPM
Breast	2.1 nTPM
Skeletal muscle	1.6 nTPM
Esophagus	1.6 nTPM
Ovary	0.9 nTPM
Endometrium	0.6 nTPM
Adipose tissue	0.6 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	3.7 nTPM
Esophagus	12.3 nTPM
Adipose tissue	4.5 nTPM
Stomach	1.0 nTPM
Spleen	0.6 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	1.4 nTPM
Lung	1.5 nTPM
Bronchus	1.3 nTPM

Smooth muscle cells	4.8 nTPM
Heart muscle	13.6 nTPM
Pancreas	13.5 nTPM
Ovary	6.5 nTPM
Skin	6.3 nTPM
Skeletal muscle	2.9 nTPM
Adipose tissue	2.5 nTPM
Prostate	2.2 nTPM
Endometrium	1.9 nTPM
Breast	1.7 nTPM
Esophagus	1.5 nTPM
Bronchus	0.0 nTPM

T-cells	3.8 nTPM
Kidney	9.6 nTPM
Lung	9.1 nTPM
Skin	6.9 nTPM
PBMC	6.8 nTPM
Esophagus	6.6 nTPM
Colon	5.2 nTPM
Liver	4.3 nTPM
Skeletal muscle	2.8 nTPM
Spleen	2.7 nTPM
Bone marrow	2.5 nTPM
Breast	2.1 nTPM
Adipose tissue	1.7 nTPM
Stomach	1.4 nTPM
Endometrium	1.3 nTPM
Lymph node	0.8 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM

Astrocytes	54.2 nTPM
Brain	54.2 nTPM

Early spermatids	65.4 nTPM
Testis	65.4 nTPM

Excitatory neurons	34.0 nTPM
Brain	34.0 nTPM

Exocrine glandular cells	10.7 nTPM
Pancreas	10.7 nTPM

Undifferentiated cells	0.6 nTPM
Rectum	0.8 nTPM
Small intestine	0.6 nTPM
Colon	0.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC