Single cell type - COMMD8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COMMD8
Gene descriptionⁱ Full gene name according to HGNC.	COMM domain containing 8
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

COMMD8 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MRPL34	Mitochondrial ribosomal protein L34	0.6468	39
COA5	Cytochrome c oxidase assembly factor 5	0.6079	39
C1QTNF12	C1q and TNF related 12	0.5896	67
NFS1	NFS1 cysteine desulfurase	0.5874	67
IMPA2	Inositol monophosphatase 2	0.5773	67
HJV	Hemojuvelin BMP co-receptor	0.5745	67
C2orf76	Chromosome 2 open reading frame 76	0.5612	39
LACTB2	Lactamase beta 2	0.5555	67
CRYZ	Crystallin zeta	0.5509	67
AIF1L	Allograft inflammatory factor 1 like	0.5358	7
SPSB2	SplA/ryanodine receptor domain and SOCS box containing 2	0.5338	66
CCNA1	Cyclin A1	0.5227	66
SLC5A2	Solute carrier family 5 member 2	0.5205	67
CATIP	Ciliogenesis associated TTC17 interacting protein	0.5194	49
MRPL19	Mitochondrial ribosomal protein L19	0.5187	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.3 nTPM
Breast	37.0 nTPM
Adipose tissue	25.6 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	16.5 nTPM
Lung	16.5 nTPM

Astrocytes	3.3 nTPM
Brain	3.3 nTPM

B-cells	41.6 nTPM
Kidney	104.8 nTPM
Liver	46.2 nTPM
PBMC	44.2 nTPM
Stomach	40.4 nTPM
Spleen	36.0 nTPM
Bone marrow	33.5 nTPM
Lymph node	32.4 nTPM
Breast	29.4 nTPM
Colon	27.1 nTPM
Adipose tissue	21.6 nTPM

Dendritic cells	39.1 nTPM
Breast	58.3 nTPM
Adipose tissue	31.0 nTPM
PBMC	27.9 nTPM

Endothelial cells	26.7 nTPM
Heart muscle	64.2 nTPM
Pancreas	38.6 nTPM
Placenta	35.8 nTPM
Testis	29.3 nTPM
Ovary	27.5 nTPM
Esophagus	24.3 nTPM
Skin	24.2 nTPM
Skeletal muscle	24.0 nTPM
Breast	24.0 nTPM
Lung	21.8 nTPM
Endometrium	18.1 nTPM
Liver	15.6 nTPM
Eye	13.7 nTPM
Prostate	12.4 nTPM

Fibroblasts	28.6 nTPM
Placenta	49.6 nTPM
Ovary	36.4 nTPM
Heart muscle	34.4 nTPM
Adipose tissue	33.5 nTPM
Skeletal muscle	28.8 nTPM
Skin	28.7 nTPM
Breast	25.7 nTPM
Stomach	25.3 nTPM
Esophagus	20.8 nTPM
Lung	19.0 nTPM
Prostate	12.9 nTPM

Intestinal goblet cells	19.4 nTPM
Rectum	23.2 nTPM
Small intestine	20.1 nTPM
Colon	15.0 nTPM

Macrophages	50.7 nTPM
Kidney	95.3 nTPM
Bone marrow	68.7 nTPM
Testis	62.1 nTPM
Prostate	59.6 nTPM
Spleen	58.1 nTPM
Ovary	54.4 nTPM
Breast	54.1 nTPM
Lung	50.4 nTPM
Endometrium	49.5 nTPM
Stomach	46.9 nTPM
Skeletal muscle	43.7 nTPM
Pancreas	40.8 nTPM
Adipose tissue	31.8 nTPM
Esophagus	31.5 nTPM
PBMC	13.6 nTPM

Paneth cells	23.8 nTPM
Small intestine	37.6 nTPM
Rectum	23.7 nTPM
Colon	9.9 nTPM

Plasma cells	22.9 nTPM
Spleen	41.6 nTPM
Bone marrow	24.7 nTPM
Stomach	18.8 nTPM
Esophagus	18.4 nTPM
Adipose tissue	10.9 nTPM

Respiratory ciliated cells	57.4 nTPM
Bronchus	57.9 nTPM
Lung	56.9 nTPM

Smooth muscle cells	29.9 nTPM
Heart muscle	74.0 nTPM
Pancreas	63.2 nTPM
Ovary	26.7 nTPM
Bronchus	26.1 nTPM
Breast	26.0 nTPM
Endometrium	23.6 nTPM
Skin	23.3 nTPM
Skeletal muscle	22.3 nTPM
Adipose tissue	19.7 nTPM
Esophagus	14.0 nTPM
Prostate	9.7 nTPM

T-cells	53.9 nTPM
Stomach	89.6 nTPM
Kidney	86.9 nTPM
Esophagus	72.0 nTPM
Skin	64.0 nTPM
Ovary	60.1 nTPM
Bone marrow	58.4 nTPM
Liver	58.2 nTPM
Colon	57.5 nTPM
Lung	54.6 nTPM
Breast	54.6 nTPM
PBMC	52.3 nTPM
Skeletal muscle	45.0 nTPM
Spleen	41.4 nTPM
Endometrium	37.4 nTPM
Lymph node	33.0 nTPM
Adipose tissue	28.0 nTPM
Prostate	23.6 nTPM

Basal keratinocytes	22.6 nTPM
Skin	22.6 nTPM

Basal prostatic cells	11.4 nTPM
Prostate	11.4 nTPM

Basal respiratory cells	60.5 nTPM
Bronchus	60.5 nTPM

Cholangiocytes	18.6 nTPM
Liver	18.6 nTPM

Undifferentiated cells	28.8 nTPM
Small intestine	33.2 nTPM
Colon	27.6 nTPM
Rectum	25.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC