Single cell type - DHRSX - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DHRSX
Gene descriptionⁱ Full gene name according to HGNC.	Dehydrogenase/reductase X-linked
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic cells - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DHRSX is part of cluster 1 Pancreatic cells - Digestion with confidenceⁱ 0.67
148 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GALNT2	Polypeptide N-acetylgalactosaminyltransferase 2	0.5203	55
CD63	CD63 molecule	0.5069	16
PSMA1	Proteasome 20S subunit alpha 1	0.4921	47
TTC17	Tetratricopeptide repeat domain 17	0.4671	59
ATP6V0E1	ATPase H+ transporting V0 subunit e1	0.4582	26
MTHFS	Methenyltetrahydrofolate synthetase	0.4528	18
KRT8	Keratin 8	0.4464	16
NUBP1	Nucleotide binding protein 1	0.4404	3
DENND5B	DENN domain containing 5B	0.4358	8
ACOX3	Acyl-CoA oxidase 3, pristanoyl	0.4322	18
IL10RB	Interleukin 10 receptor subunit beta	0.4298	18
DTNA	Dystrobrevin alpha	0.4276	64
IFNAR2	Interferon alpha and beta receptor subunit 2	0.4263	55
STK38L	Serine/threonine kinase 38 like	0.4252	1
MMADHC	Metabolism of cobalamin associated D	0.4241	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.7 nTPM
Breast	9.5 nTPM
Adipose tissue	7.9 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	9.3 nTPM
Lung	9.3 nTPM

Astrocytes	64.3 nTPM
Brain	64.3 nTPM

B-cells	19.2 nTPM
Bone marrow	28.6 nTPM
Stomach	22.7 nTPM
Breast	21.3 nTPM
Spleen	20.4 nTPM
Liver	20.2 nTPM
PBMC	20.0 nTPM
Kidney	19.0 nTPM
Adipose tissue	16.1 nTPM
Lymph node	13.8 nTPM
Colon	9.6 nTPM

Dendritic cells	17.0 nTPM
PBMC	23.9 nTPM
Breast	14.6 nTPM
Adipose tissue	12.5 nTPM

Endothelial cells	14.8 nTPM
Pancreas	38.6 nTPM
Prostate	29.9 nTPM
Esophagus	16.5 nTPM
Ovary	16.0 nTPM
Placenta	15.3 nTPM
Eye	13.7 nTPM
Heart muscle	12.2 nTPM
Skin	11.2 nTPM
Liver	11.0 nTPM
Skeletal muscle	11.0 nTPM
Breast	10.5 nTPM
Testis	9.5 nTPM
Endometrium	8.1 nTPM
Lung	3.1 nTPM

Fibroblasts	26.9 nTPM
Prostate	72.7 nTPM
Adipose tissue	34.0 nTPM
Placenta	31.8 nTPM
Lung	29.0 nTPM
Esophagus	24.0 nTPM
Breast	22.6 nTPM
Skeletal muscle	19.8 nTPM
Stomach	19.3 nTPM
Heart muscle	16.8 nTPM
Skin	14.8 nTPM
Ovary	11.6 nTPM

Intestinal goblet cells	21.4 nTPM
Colon	21.5 nTPM
Small intestine	21.3 nTPM
Rectum	21.3 nTPM

Macrophages	26.3 nTPM
Pancreas	74.0 nTPM
Prostate	34.4 nTPM
Ovary	33.4 nTPM
Testis	30.3 nTPM
Kidney	29.5 nTPM
Stomach	26.4 nTPM
Spleen	26.0 nTPM
Bone marrow	25.0 nTPM
Adipose tissue	24.0 nTPM
Skeletal muscle	20.5 nTPM
Breast	20.3 nTPM
Esophagus	18.9 nTPM
Endometrium	17.7 nTPM
Lung	14.2 nTPM
PBMC	0.0 nTPM

Paneth cells	28.8 nTPM
Colon	32.9 nTPM
Rectum	31.1 nTPM
Small intestine	22.5 nTPM

Plasma cells	29.1 nTPM
Stomach	39.6 nTPM
Spleen	31.2 nTPM
Esophagus	30.7 nTPM
Bone marrow	29.7 nTPM
Adipose tissue	14.2 nTPM

Respiratory ciliated cells	14.8 nTPM
Bronchus	22.4 nTPM
Lung	7.3 nTPM

Smooth muscle cells	18.3 nTPM
Pancreas	51.1 nTPM
Ovary	28.1 nTPM
Prostate	22.2 nTPM
Heart muscle	15.6 nTPM
Bronchus	14.9 nTPM
Adipose tissue	13.9 nTPM
Breast	13.8 nTPM
Skeletal muscle	11.4 nTPM
Skin	11.2 nTPM
Endometrium	11.0 nTPM
Esophagus	7.8 nTPM

T-cells	14.0 nTPM
Liver	20.7 nTPM
Spleen	20.1 nTPM
Esophagus	19.7 nTPM
Bone marrow	19.7 nTPM
Stomach	19.7 nTPM
Ovary	15.6 nTPM
Lymph node	14.9 nTPM
Kidney	14.4 nTPM
Colon	14.2 nTPM
Adipose tissue	12.8 nTPM
Breast	11.9 nTPM
PBMC	10.8 nTPM
Endometrium	10.6 nTPM
Prostate	9.5 nTPM
Skin	9.2 nTPM
Skeletal muscle	8.2 nTPM
Lung	6.1 nTPM

Basal prostatic cells	22.9 nTPM
Prostate	22.9 nTPM

Basal respiratory cells	58.0 nTPM
Bronchus	58.0 nTPM

Cholangiocytes	25.8 nTPM
Liver	25.8 nTPM

Collecting duct cells	25.8 nTPM
Kidney	25.8 nTPM

Undifferentiated cells	24.1 nTPM
Small intestine	29.2 nTPM
Rectum	26.7 nTPM
Colon	16.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC