Single cell type - CCDC126 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCDC126
Gene descriptionⁱ Full gene name according to HGNC.	Coiled-coil domain containing 126
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Early spermatids, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Early spermatids, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CCDC126 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ARL13A	ADP ribosylation factor like GTPase 13A	0.9143	34
NOXRED1	NADP dependent oxidoreductase domain containing 1	0.8810	34
ADAM29	ADAM metallopeptidase domain 29	0.8476	34
DDX20	DEAD-box helicase 20	0.8306	34
ZNF679	Zinc finger protein 679	0.8302	34
PLCZ1	Phospholipase C zeta 1	0.8229	34
TBC1D3F	TBC1 domain family member 3F	0.8164	34
PRSS54	Serine protease 54	0.8161	29
PRB4	Proline rich protein BstNI subfamily 4	0.8068	34
TAS2R1	Taste 2 receptor member 1	0.8059	34
SPATA9	Spermatogenesis associated 9	0.7954	34
TMEM191B	Transmembrane protein 191B	0.7888	34
C9orf153	Chromosome 9 open reading frame 153	0.7724	34
OR4N4	Olfactory receptor family 4 subfamily N member 4	0.7636	34
TMEM191C	Transmembrane protein 191C	0.7611	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.3 nTPM
Adipose tissue	19.3 nTPM
Breast	15.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	8.1 nTPM
Lung	8.1 nTPM

Astrocytes	12.7 nTPM
Brain	12.7 nTPM

B-cells	12.8 nTPM
Lymph node	21.0 nTPM
Adipose tissue	18.0 nTPM
Breast	17.3 nTPM
Spleen	16.9 nTPM
Stomach	12.3 nTPM
Kidney	9.5 nTPM
Liver	8.8 nTPM
PBMC	8.5 nTPM
Colon	8.0 nTPM
Bone marrow	7.4 nTPM

Dendritic cells	9.3 nTPM
Breast	12.4 nTPM
Adipose tissue	11.4 nTPM
PBMC	4.0 nTPM

Endothelial cells	10.8 nTPM
Heart muscle	17.7 nTPM
Skin	14.5 nTPM
Endometrium	14.2 nTPM
Testis	13.3 nTPM
Skeletal muscle	12.7 nTPM
Prostate	12.1 nTPM
Esophagus	11.3 nTPM
Breast	10.6 nTPM
Liver	10.1 nTPM
Eye	8.9 nTPM
Placenta	8.6 nTPM
Pancreas	7.7 nTPM
Ovary	6.9 nTPM
Lung	3.1 nTPM

Fibroblasts	11.5 nTPM
Adipose tissue	17.6 nTPM
Prostate	15.8 nTPM
Heart muscle	13.4 nTPM
Breast	13.3 nTPM
Skeletal muscle	13.1 nTPM
Skin	12.6 nTPM
Lung	12.3 nTPM
Stomach	10.4 nTPM
Esophagus	9.0 nTPM
Placenta	5.9 nTPM
Ovary	3.5 nTPM

Intestinal goblet cells	8.7 nTPM
Rectum	10.7 nTPM
Small intestine	9.7 nTPM
Colon	5.8 nTPM

Macrophages	9.5 nTPM
Kidney	15.8 nTPM
Skeletal muscle	13.3 nTPM
Pancreas	12.8 nTPM
Esophagus	12.6 nTPM
Adipose tissue	12.5 nTPM
Breast	11.3 nTPM
Bone marrow	10.0 nTPM
Endometrium	9.9 nTPM
Testis	9.8 nTPM
Spleen	9.3 nTPM
Ovary	7.5 nTPM
Stomach	5.9 nTPM
Prostate	5.7 nTPM
Lung	5.4 nTPM
PBMC	0.0 nTPM

Paneth cells	7.3 nTPM
Small intestine	15.0 nTPM
Rectum	7.0 nTPM
Colon	0.0 nTPM

Plasma cells	12.8 nTPM
Esophagus	24.6 nTPM
Stomach	13.5 nTPM
Adipose tissue	10.9 nTPM
Spleen	10.1 nTPM
Bone marrow	5.0 nTPM

Respiratory ciliated cells	14.6 nTPM
Bronchus	18.9 nTPM
Lung	10.2 nTPM

Smooth muscle cells	12.9 nTPM
Adipose tissue	19.9 nTPM
Endometrium	17.4 nTPM
Heart muscle	15.8 nTPM
Skin	15.0 nTPM
Prostate	13.8 nTPM
Ovary	12.4 nTPM
Skeletal muscle	12.0 nTPM
Breast	11.7 nTPM
Bronchus	8.4 nTPM
Pancreas	8.3 nTPM
Esophagus	7.8 nTPM

T-cells	11.3 nTPM
Kidney	17.8 nTPM
Skin	17.5 nTPM
Bone marrow	15.1 nTPM
Stomach	14.4 nTPM
Spleen	13.6 nTPM
Esophagus	13.1 nTPM
Breast	12.6 nTPM
Lymph node	11.8 nTPM
Adipose tissue	11.4 nTPM
PBMC	11.1 nTPM
Skeletal muscle	9.5 nTPM
Liver	9.3 nTPM
Lung	9.1 nTPM
Endometrium	7.6 nTPM
Colon	7.1 nTPM
Ovary	6.7 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	19.1 nTPM
Skin	19.1 nTPM

Basal prostatic cells	7.9 nTPM
Prostate	7.9 nTPM

Distal tubular cells	7.9 nTPM
Kidney	7.9 nTPM

Early spermatids	642.3 nTPM
Testis	642.3 nTPM

Undifferentiated cells	5.9 nTPM
Small intestine	8.2 nTPM
Rectum	6.3 nTPM
Colon	3.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC