Single cell type - ADRB2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADRB2
Gene descriptionⁱ Full gene name according to HGNC.	Adrenoceptor beta 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	FDA approved drug targets G-protein coupled receptors Human disease related genes Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Squamous epithelial cells - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Adipocytes, Basal respiratory cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (hTCEpi, hTERT-HME1, PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Adipocytes, Basal respiratory cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ADRB2 is part of cluster 61 Squamous epithelial cells - Keratinization with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GSDMC	Gasdermin C	0.7771	61
PKP1	Plakophilin 1	0.7757	61
CAPNS2	Calpain small subunit 2	0.7687	61
LY6D	Lymphocyte antigen 6 family member D	0.7469	61
LGALS7	Galectin 7	0.7360	61
KRT5	Keratin 5	0.7319	61
SOX15	SRY-box transcription factor 15	0.7170	61
DSC3	Desmocollin 3	0.7128	61
FGFBP1	Fibroblast growth factor binding protein 1	0.7089	61
DSG3	Desmoglein 3	0.7051	61
TP63	Tumor protein p63	0.7034	61
SLURP1	Secreted LY6/PLAUR domain containing 1	0.7008	61
SERPINB5	Serpin family B member 5	0.7004	61
CLCA2	Chloride channel accessory 2	0.6898	61
IVL	Involucrin	0.6898	61

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	112.2 nTPM
Lung	112.2 nTPM

Alveolar cells type 2	31.6 nTPM
Lung	31.6 nTPM

Astrocytes	1.6 nTPM
Brain	1.6 nTPM

B-cells	16.5 nTPM
Lymph node	33.7 nTPM
Breast	28.1 nTPM
Stomach	23.6 nTPM
Adipose tissue	18.0 nTPM
Kidney	14.3 nTPM
Spleen	11.8 nTPM
PBMC	9.9 nTPM
Colon	9.6 nTPM
Bone marrow	9.0 nTPM
Liver	7.1 nTPM

Basal prostatic cells	36.6 nTPM
Prostate	36.6 nTPM

Adipocytes	196.1 nTPM
Adipose tissue	265.5 nTPM
Breast	126.8 nTPM

Basal squamous epithelial cells	127.5 nTPM
Esophagus	127.5 nTPM

Dendritic cells	59.2 nTPM
Adipose tissue	82.8 nTPM
Breast	82.7 nTPM
PBMC	12.0 nTPM

Endothelial cells	40.3 nTPM
Skin	166.1 nTPM
Esophagus	100.3 nTPM
Breast	93.8 nTPM
Skeletal muscle	78.2 nTPM
Prostate	41.7 nTPM
Eye	22.7 nTPM
Heart muscle	22.6 nTPM
Lung	18.7 nTPM
Pancreas	7.7 nTPM
Ovary	3.4 nTPM
Testis	3.0 nTPM
Placenta	2.9 nTPM
Endometrium	1.8 nTPM
Liver	0.9 nTPM

Fibroblasts	6.2 nTPM
Skin	23.8 nTPM
Heart muscle	12.2 nTPM
Lung	8.9 nTPM
Stomach	7.4 nTPM
Esophagus	5.9 nTPM
Breast	4.0 nTPM
Prostate	3.4 nTPM
Placenta	1.3 nTPM
Skeletal muscle	1.3 nTPM
Adipose tissue	0.6 nTPM
Ovary	0.0 nTPM

Intestinal goblet cells	3.1 nTPM
Colon	7.2 nTPM
Rectum	1.8 nTPM
Small intestine	0.4 nTPM

Macrophages	21.1 nTPM
Breast	63.9 nTPM
Endometrium	43.4 nTPM
Esophagus	34.6 nTPM
Adipose tissue	30.0 nTPM
Skeletal muscle	20.3 nTPM
Testis	18.6 nTPM
Prostate	17.2 nTPM
Lung	16.9 nTPM
Ovary	16.7 nTPM
Spleen	15.6 nTPM
Kidney	12.0 nTPM
Stomach	11.7 nTPM
Pancreas	7.7 nTPM
Bone marrow	7.5 nTPM
PBMC	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	23.2 nTPM
Adipose tissue	48.3 nTPM
Esophagus	36.9 nTPM
Stomach	16.1 nTPM
Spleen	7.8 nTPM
Bone marrow	6.6 nTPM

Respiratory ciliated cells	27.8 nTPM
Bronchus	46.8 nTPM
Lung	8.7 nTPM

Early spermatids	0.5 nTPM
Testis	0.5 nTPM

Endometrial stromal cells	0.5 nTPM
Endometrium	0.5 nTPM

Exocrine glandular cells	0.2 nTPM
Pancreas	0.2 nTPM

Smooth muscle cells	9.6 nTPM
Bronchus	35.0 nTPM
Skin	22.7 nTPM
Skeletal muscle	13.2 nTPM
Breast	11.5 nTPM
Esophagus	10.9 nTPM
Prostate	4.1 nTPM
Heart muscle	3.7 nTPM
Adipose tissue	3.6 nTPM
Endometrium	0.7 nTPM
Ovary	0.1 nTPM
Pancreas	0.0 nTPM

T-cells	40.1 nTPM
Kidney	91.1 nTPM
Prostate	71.1 nTPM
Adipose tissue	60.7 nTPM
Ovary	57.8 nTPM
Liver	55.9 nTPM
Esophagus	45.9 nTPM
Breast	43.9 nTPM
Skeletal muscle	42.0 nTPM
Bone marrow	37.5 nTPM
Skin	35.4 nTPM
Spleen	27.8 nTPM
Endometrium	26.8 nTPM
Lung	25.8 nTPM
PBMC	24.0 nTPM
Lymph node	14.0 nTPM
Stomach	13.1 nTPM
Colon	9.5 nTPM

Undifferentiated cells	3.5 nTPM
Colon	8.5 nTPM
Rectum	1.6 nTPM
Small intestine	0.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC