Single cell type - INO80E - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	INO80E
Gene descriptionⁱ Full gene name according to HGNC.	INO80 complex subunit E
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

INO80E is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RPP21	Ribonuclease P/MRP subunit p21	0.6509	59
ERVK3-1	Endogenous retrovirus group K3 member 1	0.6431	59
POC1B-GALNT4	POC1B-GALNT4 readthrough	0.5800	59
CXXC1	CXXC finger protein 1	0.5782	53
ANKHD1	Ankyrin repeat and KH domain containing 1	0.5674	59
HNRNPL	Heterogeneous nuclear ribonucleoprotein L	0.5657	59
BCKDHA	Branched chain keto acid dehydrogenase E1 subunit alpha	0.5359	59
MDC1	Mediator of DNA damage checkpoint 1	0.5346	13
DPH1	Diphthamide biosynthesis 1	0.5236	59
MRPL38	Mitochondrial ribosomal protein L38	0.5233	59
TRIM34	Tripartite motif containing 34	0.5215	59
DIABLO	Diablo IAP-binding mitochondrial protein	0.5168	59
HCRT	Hypocretin neuropeptide precursor	0.5166	58
PRICKLE4	Prickle planar cell polarity protein 4	0.5166	59
ARPC4-TTLL3	ARPC4-TTLL3 readthrough	0.5147	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.8 nTPM
Breast	34.0 nTPM
Adipose tissue	31.6 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	19.6 nTPM
Lung	19.6 nTPM

Astrocytes	15.0 nTPM
Brain	15.0 nTPM

B-cells	27.6 nTPM
Lymph node	45.6 nTPM
Stomach	42.2 nTPM
Liver	35.1 nTPM
Bone marrow	35.1 nTPM
Spleen	34.3 nTPM
Breast	29.4 nTPM
Colon	19.2 nTPM
Kidney	14.3 nTPM
Adipose tissue	10.5 nTPM
PBMC	9.9 nTPM

Dendritic cells	27.6 nTPM
Breast	34.2 nTPM
PBMC	27.9 nTPM
Adipose tissue	20.6 nTPM

Endothelial cells	25.4 nTPM
Esophagus	40.0 nTPM
Placenta	37.5 nTPM
Liver	34.8 nTPM
Ovary	30.8 nTPM
Testis	28.8 nTPM
Breast	28.7 nTPM
Lung	28.1 nTPM
Skeletal muscle	25.7 nTPM
Eye	23.5 nTPM
Pancreas	23.1 nTPM
Skin	21.8 nTPM
Endometrium	18.2 nTPM
Prostate	12.1 nTPM
Heart muscle	1.6 nTPM

Fibroblasts	20.2 nTPM
Esophagus	34.2 nTPM
Stomach	32.7 nTPM
Ovary	22.6 nTPM
Placenta	22.3 nTPM
Adipose tissue	21.3 nTPM
Breast	20.4 nTPM
Skin	20.3 nTPM
Lung	20.1 nTPM
Skeletal muscle	17.2 nTPM
Prostate	9.5 nTPM
Heart muscle	1.2 nTPM

Intestinal goblet cells	28.4 nTPM
Small intestine	32.4 nTPM
Rectum	27.1 nTPM
Colon	25.7 nTPM

Macrophages	24.0 nTPM
Pancreas	51.0 nTPM
Bone marrow	36.3 nTPM
Esophagus	36.2 nTPM
Kidney	29.5 nTPM
Breast	27.9 nTPM
Testis	27.8 nTPM
Lung	23.1 nTPM
Endometrium	22.9 nTPM
Stomach	20.5 nTPM
Skeletal muscle	19.7 nTPM
Adipose tissue	19.4 nTPM
Spleen	17.6 nTPM
Ovary	15.1 nTPM
Prostate	13.8 nTPM
PBMC	0.0 nTPM

Paneth cells	39.7 nTPM
Colon	59.3 nTPM
Small intestine	30.0 nTPM
Rectum	29.7 nTPM

Plasma cells	35.2 nTPM
Spleen	46.7 nTPM
Stomach	40.1 nTPM
Esophagus	36.9 nTPM
Bone marrow	33.0 nTPM
Adipose tissue	19.4 nTPM

Respiratory ciliated cells	19.7 nTPM
Bronchus	27.6 nTPM
Lung	11.7 nTPM

Smooth muscle cells	23.1 nTPM
Esophagus	46.5 nTPM
Pancreas	43.2 nTPM
Breast	27.1 nTPM
Skin	26.8 nTPM
Skeletal muscle	24.6 nTPM
Adipose tissue	24.3 nTPM
Endometrium	17.0 nTPM
Ovary	16.4 nTPM
Prostate	15.7 nTPM
Bronchus	12.2 nTPM
Heart muscle	0.6 nTPM

T-cells	30.9 nTPM
Lymph node	45.6 nTPM
Spleen	45.6 nTPM
Stomach	43.6 nTPM
Bone marrow	40.8 nTPM
Liver	33.3 nTPM
Breast	32.9 nTPM
Esophagus	32.8 nTPM
Colon	31.8 nTPM
Skin	29.5 nTPM
Prostate	28.4 nTPM
PBMC	26.6 nTPM
Lung	25.8 nTPM
Ovary	24.5 nTPM
Skeletal muscle	23.1 nTPM
Kidney	21.2 nTPM
Endometrium	20.3 nTPM
Adipose tissue	20.0 nTPM

Basal keratinocytes	14.8 nTPM
Skin	14.8 nTPM

Basal prostatic cells	19.1 nTPM
Prostate	19.1 nTPM

Basal squamous epithelial cells	37.0 nTPM
Esophagus	37.0 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Undifferentiated cells	31.6 nTPM
Small intestine	35.5 nTPM
Rectum	30.7 nTPM
Colon	28.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC