Single cell type - ZNF32 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF32
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 32
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZNF32 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BOLA1	BolA family member 1	0.5786	39
TMEM203	Transmembrane protein 203	0.5696	10
THAP11	THAP domain containing 11	0.5546	32
DNAJC19	DnaJ heat shock protein family (Hsp40) member C19	0.5466	39
ZNF22	Zinc finger protein 22	0.5390	32
HDDC2	HD domain containing 2	0.5322	39
PEX2	Peroxisomal biogenesis factor 2	0.5176	39
C6orf226	Chromosome 6 open reading frame 226	0.5157	39
THYN1	Thymocyte nuclear protein 1	0.5097	39
TYW3	TRNA-yW synthesizing protein 3 homolog	0.5044	39
ZNF580	Zinc finger protein 580	0.4923	48
NUDT2	Nudix hydrolase 2	0.4917	39
RBM43	RNA binding motif protein 43	0.4894	50
RNF187	Ring finger protein 187	0.4881	52
HSCB	HscB mitochondrial iron-sulfur cluster cochaperone	0.4851	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.1 nTPM
Breast	37.1 nTPM
Adipose tissue	15.1 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	14.3 nTPM
Lung	14.3 nTPM

Astrocytes	14.0 nTPM
Brain	14.0 nTPM

B-cells	18.8 nTPM
PBMC	29.9 nTPM
Colon	23.9 nTPM
Breast	22.8 nTPM
Spleen	20.1 nTPM
Kidney	19.0 nTPM
Adipose tissue	18.0 nTPM
Bone marrow	15.5 nTPM
Stomach	13.2 nTPM
Liver	12.9 nTPM
Lymph node	12.4 nTPM

Dendritic cells	31.9 nTPM
PBMC	39.8 nTPM
Breast	33.5 nTPM
Adipose tissue	22.5 nTPM

Endothelial cells	23.8 nTPM
Liver	51.3 nTPM
Testis	36.7 nTPM
Breast	31.0 nTPM
Placenta	27.8 nTPM
Esophagus	25.0 nTPM
Eye	24.2 nTPM
Skin	22.1 nTPM
Ovary	21.9 nTPM
Prostate	21.8 nTPM
Skeletal muscle	21.4 nTPM
Endometrium	20.8 nTPM
Pancreas	15.5 nTPM
Lung	9.3 nTPM
Heart muscle	4.6 nTPM

Fibroblasts	27.3 nTPM
Breast	48.7 nTPM
Ovary	39.4 nTPM
Adipose tissue	35.5 nTPM
Esophagus	34.6 nTPM
Skeletal muscle	30.9 nTPM
Prostate	25.3 nTPM
Placenta	21.8 nTPM
Skin	21.7 nTPM
Stomach	20.8 nTPM
Lung	16.8 nTPM
Heart muscle	5.4 nTPM

Intestinal goblet cells	16.0 nTPM
Rectum	23.6 nTPM
Small intestine	19.5 nTPM
Colon	5.0 nTPM

Macrophages	19.0 nTPM
Ovary	30.2 nTPM
Breast	29.2 nTPM
Prostate	27.5 nTPM
Testis	27.4 nTPM
Spleen	22.8 nTPM
Esophagus	20.4 nTPM
Kidney	17.5 nTPM
Lung	16.3 nTPM
Pancreas	15.3 nTPM
Bone marrow	15.0 nTPM
Stomach	14.7 nTPM
Skeletal muscle	13.9 nTPM
PBMC	13.6 nTPM
Adipose tissue	10.6 nTPM
Endometrium	9.9 nTPM

Paneth cells	10.3 nTPM
Rectum	15.9 nTPM
Small intestine	15.0 nTPM
Colon	0.0 nTPM

Plasma cells	9.5 nTPM
Stomach	18.4 nTPM
Esophagus	12.3 nTPM
Adipose tissue	10.3 nTPM
Bone marrow	3.3 nTPM
Spleen	2.9 nTPM

Respiratory ciliated cells	12.6 nTPM
Lung	14.6 nTPM
Bronchus	10.5 nTPM

Smooth muscle cells	34.2 nTPM
Bronchus	51.7 nTPM
Breast	49.2 nTPM
Esophagus	44.9 nTPM
Skeletal muscle	37.8 nTPM
Ovary	35.8 nTPM
Prostate	31.9 nTPM
Adipose tissue	28.6 nTPM
Heart muscle	27.0 nTPM
Pancreas	26.2 nTPM
Endometrium	24.8 nTPM
Skin	18.8 nTPM

T-cells	27.1 nTPM
PBMC	54.9 nTPM
Kidney	45.8 nTPM
Ovary	40.0 nTPM
Liver	38.9 nTPM
Breast	29.5 nTPM
Bone marrow	29.4 nTPM
Spleen	27.6 nTPM
Lung	24.3 nTPM
Lymph node	24.3 nTPM
Colon	23.7 nTPM
Stomach	21.0 nTPM
Skeletal muscle	20.1 nTPM
Adipose tissue	19.1 nTPM
Prostate	19.0 nTPM
Endometrium	15.7 nTPM
Skin	13.8 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	11.0 nTPM
Skin	11.0 nTPM

Basal prostatic cells	24.4 nTPM
Prostate	24.4 nTPM

Basal squamous epithelial cells	33.0 nTPM
Esophagus	33.0 nTPM

Cone photoreceptor cells	8.4 nTPM
Eye	8.4 nTPM

Undifferentiated cells	17.9 nTPM
Rectum	24.7 nTPM
Small intestine	23.2 nTPM
Colon	5.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC