Single cell type - UGP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UGP2
Gene descriptionⁱ Full gene name according to HGNC.	UDP-glucose pyrophosphorylase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mammary glandular cells - Lactation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Hepatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Hepatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UGP2 is part of cluster 30 Mammary glandular cells - Lactation with confidenceⁱ 1
85 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
XDH	Xanthine dehydrogenase	0.7274	30
FASN	Fatty acid synthase	0.6472	30
MROH6	Maestro heat like repeat family member 6	0.6408	53
SERINC2	Serine incorporator 2	0.6267	53
CA6	Carbonic anhydrase 6	0.6260	30
CSN1S1	Casein alpha s1	0.6250	30
CSN3	Casein kappa	0.6244	30
CSN2	Casein beta	0.6243	30
LALBA	Lactalbumin alpha	0.6243	30
CCL28	C-C motif chemokine ligand 28	0.6231	30
CIDEA	Cell death inducing DFFA like effector a	0.6219	30
BTN1A1	Butyrophilin subfamily 1 member A1	0.6210	30
C6orf15	Chromosome 6 open reading frame 15	0.6208	30
ELF5	E74 like ETS transcription factor 5	0.6206	30
STATH	Statherin	0.6179	30

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	73.4 nTPM
Breast	76.1 nTPM
Adipose tissue	70.7 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	54.0 nTPM
Lung	54.0 nTPM

Astrocytes	107.4 nTPM
Brain	107.4 nTPM

B-cells	65.3 nTPM
PBMC	101.4 nTPM
Kidney	100.0 nTPM
Liver	71.0 nTPM
Lymph node	70.0 nTPM
Colon	62.3 nTPM
Adipose tissue	60.2 nTPM
Spleen	51.2 nTPM
Stomach	48.6 nTPM
Bone marrow	44.2 nTPM
Breast	44.1 nTPM

Dendritic cells	81.1 nTPM
Adipose tissue	114.6 nTPM
Breast	68.9 nTPM
PBMC	59.8 nTPM

Endothelial cells	69.8 nTPM
Lung	112.3 nTPM
Skin	99.6 nTPM
Breast	96.1 nTPM
Prostate	74.9 nTPM
Heart muscle	69.5 nTPM
Liver	68.8 nTPM
Esophagus	66.1 nTPM
Placenta	66.0 nTPM
Testis	63.7 nTPM
Skeletal muscle	61.9 nTPM
Pancreas	61.8 nTPM
Eye	55.8 nTPM
Endometrium	40.8 nTPM
Ovary	40.1 nTPM

Fibroblasts	159.3 nTPM
Adipose tissue	411.7 nTPM
Lung	218.9 nTPM
Placenta	181.5 nTPM
Skin	177.0 nTPM
Heart muscle	147.9 nTPM
Esophagus	129.7 nTPM
Skeletal muscle	129.0 nTPM
Breast	113.0 nTPM
Prostate	101.9 nTPM
Stomach	75.7 nTPM
Ovary	66.0 nTPM

Intestinal goblet cells	179.8 nTPM
Colon	307.4 nTPM
Rectum	162.8 nTPM
Small intestine	69.3 nTPM

Macrophages	89.1 nTPM
Pancreas	201.6 nTPM
PBMC	122.7 nTPM
Prostate	100.9 nTPM
Testis	100.5 nTPM
Lung	100.0 nTPM
Kidney	99.1 nTPM
Adipose tissue	94.0 nTPM
Bone marrow	81.2 nTPM
Breast	81.2 nTPM
Ovary	78.0 nTPM
Endometrium	70.4 nTPM
Spleen	66.4 nTPM
Skeletal muscle	56.5 nTPM
Esophagus	42.5 nTPM
Stomach	41.0 nTPM

Paneth cells	313.9 nTPM
Colon	685.1 nTPM
Rectum	185.3 nTPM
Small intestine	71.4 nTPM

Plasma cells	60.7 nTPM
Adipose tissue	79.3 nTPM
Bone marrow	69.2 nTPM
Spleen	52.8 nTPM
Stomach	52.8 nTPM
Esophagus	49.4 nTPM

Respiratory ciliated cells	139.3 nTPM
Bronchus	198.4 nTPM
Lung	80.2 nTPM

Smooth muscle cells	129.2 nTPM
Bronchus	252.3 nTPM
Esophagus	165.9 nTPM
Pancreas	143.9 nTPM
Prostate	140.4 nTPM
Skin	138.1 nTPM
Heart muscle	127.3 nTPM
Breast	121.6 nTPM
Adipose tissue	111.2 nTPM
Endometrium	93.1 nTPM
Skeletal muscle	80.0 nTPM
Ovary	47.1 nTPM

T-cells	143.1 nTPM
Adipose tissue	351.1 nTPM
Prostate	321.9 nTPM
Skin	153.3 nTPM
Kidney	145.1 nTPM
Lymph node	143.9 nTPM
PBMC	139.7 nTPM
Stomach	138.1 nTPM
Liver	127.0 nTPM
Ovary	126.8 nTPM
Colon	122.6 nTPM
Skeletal muscle	121.4 nTPM
Esophagus	117.9 nTPM
Spleen	110.3 nTPM
Breast	94.9 nTPM
Bone marrow	77.0 nTPM
Lung	74.4 nTPM
Endometrium	67.5 nTPM

Basal keratinocytes	75.8 nTPM
Skin	75.8 nTPM

Basal prostatic cells	87.8 nTPM
Prostate	87.8 nTPM

Basal respiratory cells	245.9 nTPM
Bronchus	245.9 nTPM

Basal squamous epithelial cells	34.7 nTPM
Esophagus	34.7 nTPM

Undifferentiated cells	189.5 nTPM
Colon	315.9 nTPM
Rectum	166.4 nTPM
Small intestine	86.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC