Single cell type - YWHAG - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	YWHAG
Gene descriptionⁱ Full gene name according to HGNC.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Keratinocytes - Keratinization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

YWHAG is part of cluster 28 Keratinocytes - Keratinization with confidenceⁱ 1
89 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CLEC2A	C-type lectin domain family 2 member A	0.6798	28
KRT14	Keratin 14	0.6474	28
DSC1	Desmocollin 1	0.6355	28
LIPM	Lipase family member M	0.6305	28
LCE1F	Late cornified envelope 1F	0.6221	28
LCE1B	Late cornified envelope 1B	0.6145	28
KPRP	Keratinocyte proline rich protein	0.6101	28
LCE1E	Late cornified envelope 1E	0.6096	28
SERPINA12	Serpin family A member 12	0.6085	28
WTAP	WT1 associated protein	0.6084	48
CCL27	C-C motif chemokine ligand 27	0.6062	28
KRT77	Keratin 77	0.6062	28
LCE2B	Late cornified envelope 2B	0.6040	28
KRT1	Keratin 1	0.6029	28
LCE1A	Late cornified envelope 1A	0.6022	28

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	73.7 nTPM
Adipose tissue	106.5 nTPM
Breast	40.8 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	26.4 nTPM
Lung	26.4 nTPM

Astrocytes	23.2 nTPM
Brain	23.2 nTPM

B-cells	51.8 nTPM
Lymph node	82.3 nTPM
Adipose tissue	69.2 nTPM
Liver	67.9 nTPM
Spleen	66.1 nTPM
Colon	57.5 nTPM
Bone marrow	44.2 nTPM
Stomach	43.2 nTPM
Kidney	38.1 nTPM
Breast	25.5 nTPM
PBMC	24.3 nTPM

Basal squamous epithelial cells	126.9 nTPM
Esophagus	126.9 nTPM

Dendritic cells	39.3 nTPM
Adipose tissue	50.3 nTPM
PBMC	43.8 nTPM
Breast	23.6 nTPM

Endothelial cells	92.0 nTPM
Skin	259.1 nTPM
Prostate	206.6 nTPM
Endometrium	109.3 nTPM
Esophagus	98.0 nTPM
Ovary	82.6 nTPM
Liver	81.7 nTPM
Breast	80.1 nTPM
Heart muscle	68.7 nTPM
Lung	68.6 nTPM
Skeletal muscle	55.2 nTPM
Placenta	52.8 nTPM
Eye	49.3 nTPM
Testis	45.6 nTPM
Pancreas	30.9 nTPM

Enteroendocrine cells	85.4 nTPM
Colon	110.1 nTPM
Rectum	60.6 nTPM

Fibroblasts	97.4 nTPM
Skin	260.4 nTPM
Prostate	184.2 nTPM
Adipose tissue	98.8 nTPM
Heart muscle	91.8 nTPM
Skeletal muscle	88.3 nTPM
Lung	82.7 nTPM
Stomach	66.9 nTPM
Esophagus	58.5 nTPM
Breast	53.6 nTPM
Ovary	52.1 nTPM
Placenta	34.4 nTPM

Intestinal goblet cells	35.7 nTPM
Colon	43.6 nTPM
Rectum	34.0 nTPM
Small intestine	29.4 nTPM

Macrophages	87.8 nTPM
Adipose tissue	134.3 nTPM
Spleen	121.3 nTPM
Bone marrow	119.9 nTPM
Stomach	117.2 nTPM
Prostate	111.2 nTPM
Kidney	92.3 nTPM
Skeletal muscle	85.9 nTPM
Lung	79.3 nTPM
Esophagus	77.1 nTPM
Endometrium	75.5 nTPM
Ovary	74.6 nTPM
Pancreas	68.9 nTPM
Testis	61.0 nTPM
PBMC	54.6 nTPM
Breast	44.1 nTPM

Paneth cells	29.9 nTPM
Rectum	41.8 nTPM
Colon	32.9 nTPM
Small intestine	15.0 nTPM

Plasma cells	56.6 nTPM
Spleen	72.2 nTPM
Bone marrow	67.6 nTPM
Stomach	53.1 nTPM
Adipose tissue	47.1 nTPM
Esophagus	43.0 nTPM

Respiratory ciliated cells	47.2 nTPM
Bronchus	69.6 nTPM
Lung	24.8 nTPM

Cholangiocytes	40.0 nTPM
Liver	40.0 nTPM

Collecting duct cells	38.6 nTPM
Kidney	38.6 nTPM

Cone photoreceptor cells	12.5 nTPM
Eye	12.5 nTPM

Cytotrophoblasts	36.5 nTPM
Placenta	36.5 nTPM

Smooth muscle cells	91.5 nTPM
Prostate	188.5 nTPM
Skin	163.9 nTPM
Adipose tissue	103.5 nTPM
Bronchus	95.1 nTPM
Pancreas	81.8 nTPM
Skeletal muscle	81.1 nTPM
Endometrium	75.3 nTPM
Ovary	63.2 nTPM
Esophagus	60.4 nTPM
Heart muscle	54.9 nTPM
Breast	39.2 nTPM

T-cells	41.5 nTPM
Prostate	89.9 nTPM
Skin	83.8 nTPM
Adipose tissue	72.3 nTPM
Endometrium	50.5 nTPM
Lymph node	49.7 nTPM
Esophagus	45.9 nTPM
Colon	45.1 nTPM
Spleen	39.9 nTPM
Stomach	36.7 nTPM
Breast	34.8 nTPM
Skeletal muscle	30.1 nTPM
Kidney	29.4 nTPM
Bone marrow	28.5 nTPM
Liver	23.0 nTPM
Lung	19.7 nTPM
PBMC	18.1 nTPM
Ovary	8.9 nTPM

Undifferentiated cells	45.1 nTPM
Colon	59.3 nTPM
Rectum	39.3 nTPM
Small intestine	36.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC