Single cell type - TMEM43 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM43
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 43
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 1)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 1)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM43 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MXRA8	Matrix remodeling associated 8	0.7256	50
MFAP5	Microfibril associated protein 5	0.7012	50
FSTL1	Follistatin like 1	0.6995	50
PCOLCE2	Procollagen C-endopeptidase enhancer 2	0.6948	50
OMD	Osteomodulin	0.6848	50
ACKR3	Atypical chemokine receptor 3	0.6848	50
XG	Xg glycoprotein (Xg blood group)	0.6842	50
CFD	Complement factor D	0.6783	50
COL6A3	Collagen type VI alpha 3 chain	0.6653	50
VIT	Vitrin	0.6629	50
TNXB	Tenascin XB	0.6619	50
ECM2	Extracellular matrix protein 2	0.6608	50
CCDC80	Coiled-coil domain containing 80	0.6601	50
CLEC3B	C-type lectin domain family 3 member B	0.6595	50
BOC	BOC cell adhesion associated, oncogene regulated	0.6579	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	44.2 nTPM
Adipose tissue	51.1 nTPM
Breast	37.2 nTPM

Alveolar cells type 2	46.8 nTPM
Lung	46.8 nTPM

Astrocytes	17.9 nTPM
Brain	17.9 nTPM

B-cells	16.8 nTPM
Stomach	25.9 nTPM
Bone marrow	22.9 nTPM
Lymph node	22.0 nTPM
Spleen	19.7 nTPM
Adipose tissue	19.5 nTPM
Breast	14.7 nTPM
PBMC	12.9 nTPM
Colon	12.8 nTPM
Kidney	9.5 nTPM
Liver	8.3 nTPM

Basal keratinocytes	43.7 nTPM
Skin	43.7 nTPM

Dendritic cells	43.2 nTPM
PBMC	59.8 nTPM
Breast	37.1 nTPM
Adipose tissue	32.7 nTPM

Endothelial cells	37.4 nTPM
Esophagus	53.3 nTPM
Skin	46.8 nTPM
Endometrium	45.3 nTPM
Heart muscle	44.6 nTPM
Lung	40.6 nTPM
Skeletal muscle	39.8 nTPM
Testis	39.1 nTPM
Liver	36.7 nTPM
Breast	33.4 nTPM
Prostate	32.8 nTPM
Ovary	31.3 nTPM
Pancreas	30.9 nTPM
Placenta	27.8 nTPM
Eye	21.0 nTPM

Fibroblasts	68.0 nTPM
Adipose tissue	136.1 nTPM
Skin	83.0 nTPM
Skeletal muscle	82.4 nTPM
Heart muscle	74.8 nTPM
Lung	71.5 nTPM
Breast	69.2 nTPM
Stomach	55.0 nTPM
Placenta	54.7 nTPM
Esophagus	53.5 nTPM
Prostate	39.7 nTPM
Ovary	27.7 nTPM

Intestinal goblet cells	8.3 nTPM
Rectum	10.6 nTPM
Colon	7.8 nTPM
Small intestine	6.6 nTPM

Macrophages	19.8 nTPM
Lung	43.1 nTPM
Adipose tissue	37.9 nTPM
Testis	30.3 nTPM
Skeletal muscle	27.4 nTPM
Breast	22.5 nTPM
Kidney	21.9 nTPM
Prostate	20.7 nTPM
Ovary	20.0 nTPM
Esophagus	18.9 nTPM
Endometrium	16.1 nTPM
Spleen	12.5 nTPM
Bone marrow	10.0 nTPM
Stomach	8.8 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	9.7 nTPM
Colon	13.2 nTPM
Rectum	12.2 nTPM
Small intestine	3.7 nTPM

Plasma cells	15.6 nTPM
Adipose tissue	32.8 nTPM
Stomach	16.5 nTPM
Spleen	12.6 nTPM
Bone marrow	9.9 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	16.2 nTPM
Lung	20.4 nTPM
Bronchus	12.0 nTPM

Smooth muscle cells	39.3 nTPM
Adipose tissue	60.5 nTPM
Breast	49.1 nTPM
Skeletal muscle	45.0 nTPM
Esophagus	44.9 nTPM
Heart muscle	43.0 nTPM
Pancreas	39.7 nTPM
Skin	38.0 nTPM
Endometrium	34.8 nTPM
Ovary	34.7 nTPM
Prostate	34.0 nTPM
Bronchus	8.4 nTPM

T-cells	32.1 nTPM
Skin	44.7 nTPM
Stomach	44.6 nTPM
Skeletal muscle	43.3 nTPM
Adipose tissue	42.4 nTPM
Lung	39.5 nTPM
Spleen	36.9 nTPM
Esophagus	32.8 nTPM
Breast	32.6 nTPM
Endometrium	31.3 nTPM
Ovary	31.1 nTPM
Liver	26.9 nTPM
Lymph node	26.2 nTPM
Kidney	25.3 nTPM
Bone marrow	24.3 nTPM
Colon	22.8 nTPM
PBMC	21.7 nTPM
Prostate	19.0 nTPM

Cholangiocytes	15.7 nTPM
Liver	15.7 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Cone photoreceptor cells	14.6 nTPM
Eye	14.6 nTPM

Cytotrophoblasts	31.2 nTPM
Placenta	31.2 nTPM

Undifferentiated cells	11.5 nTPM
Rectum	13.6 nTPM
Small intestine	11.8 nTPM
Colon	9.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC