Single cell type - PLRG1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLRG1
Gene descriptionⁱ Full gene name according to HGNC.	Pleiotropic regulator 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLRG1 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
S100A7	S100 calcium binding protein A7	0.7706	26
PTHLH	Parathyroid hormone like hormone	0.7534	26
SERPINB3	Serpin family B member 3	0.7498	26
MMP13	Matrix metallopeptidase 13	0.7405	26
CDC123	Cell division cycle 123	0.7364	26
FAM83A	Family with sequence similarity 83 member A	0.7331	26
KRTAP19-3	Keratin associated protein 19-3	0.7318	26
MFSD10	Major facilitator superfamily domain containing 10	0.7302	26
SPRR2D	Small proline rich protein 2D	0.7287	26
TMEM45A	Transmembrane protein 45A	0.7278	26
PGLYRP4	Peptidoglycan recognition protein 4	0.7267	26
BPIFA2	BPI fold containing family A member 2	0.7232	26
IL36G	Interleukin 36 gamma	0.7188	26
RAET1G	Retinoic acid early transcript 1G	0.7127	26
SERPINB4	Serpin family B member 4	0.7108	26

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	26.9 nTPM
Breast	29.0 nTPM
Adipose tissue	24.9 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	18.1 nTPM
Lung	18.1 nTPM

Astrocytes	29.0 nTPM
Brain	29.0 nTPM

B-cells	26.9 nTPM
Liver	36.0 nTPM
PBMC	35.7 nTPM
Kidney	33.4 nTPM
Stomach	29.0 nTPM
Colon	28.7 nTPM
Bone marrow	28.6 nTPM
Spleen	22.2 nTPM
Lymph node	21.6 nTPM
Adipose tissue	19.5 nTPM
Breast	14.7 nTPM

Dendritic cells	23.6 nTPM
Adipose tissue	30.1 nTPM
Breast	28.8 nTPM
PBMC	12.0 nTPM

Endothelial cells	27.5 nTPM
Pancreas	77.2 nTPM
Ovary	31.8 nTPM
Heart muscle	29.5 nTPM
Testis	26.4 nTPM
Endometrium	25.7 nTPM
Lung	24.9 nTPM
Skeletal muscle	23.9 nTPM
Liver	23.8 nTPM
Placenta	23.3 nTPM
Esophagus	22.8 nTPM
Breast	22.7 nTPM
Prostate	18.3 nTPM
Skin	17.4 nTPM
Eye	17.0 nTPM

Fibroblasts	30.9 nTPM
Lung	44.6 nTPM
Adipose tissue	35.6 nTPM
Ovary	34.7 nTPM
Heart muscle	34.5 nTPM
Placenta	32.8 nTPM
Skeletal muscle	30.6 nTPM
Esophagus	29.4 nTPM
Breast	29.3 nTPM
Skin	22.9 nTPM
Prostate	22.8 nTPM
Stomach	22.3 nTPM

Intestinal goblet cells	15.9 nTPM
Rectum	16.9 nTPM
Colon	16.5 nTPM
Small intestine	14.3 nTPM

Macrophages	17.2 nTPM
Pancreas	35.7 nTPM
Breast	25.6 nTPM
Lung	22.7 nTPM
Testis	22.1 nTPM
Ovary	21.3 nTPM
Endometrium	19.1 nTPM
Adipose tissue	18.1 nTPM
Kidney	17.5 nTPM
Bone marrow	17.5 nTPM
Skeletal muscle	16.9 nTPM
Prostate	13.8 nTPM
Esophagus	11.0 nTPM
Stomach	8.8 nTPM
Spleen	8.3 nTPM
PBMC	0.0 nTPM

Paneth cells	20.9 nTPM
Small intestine	26.3 nTPM
Rectum	23.1 nTPM
Colon	13.2 nTPM

Plasma cells	21.8 nTPM
Bone marrow	33.0 nTPM
Spleen	25.9 nTPM
Adipose tissue	19.4 nTPM
Stomach	18.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	45.2 nTPM
Bronchus	49.6 nTPM
Lung	40.8 nTPM

Smooth muscle cells	40.8 nTPM
Bronchus	135.6 nTPM
Pancreas	66.7 nTPM
Ovary	39.4 nTPM
Breast	35.4 nTPM
Skeletal muscle	28.5 nTPM
Adipose tissue	28.0 nTPM
Prostate	27.8 nTPM
Endometrium	26.3 nTPM
Skin	23.0 nTPM
Esophagus	21.7 nTPM
Heart muscle	16.2 nTPM

T-cells	26.9 nTPM
Ovary	48.9 nTPM
Stomach	36.3 nTPM
Kidney	33.6 nTPM
PBMC	32.3 nTPM
Lung	31.9 nTPM
Bone marrow	29.9 nTPM
Adipose tissue	29.6 nTPM
Breast	28.5 nTPM
Liver	27.4 nTPM
Lymph node	24.6 nTPM
Spleen	24.5 nTPM
Colon	24.2 nTPM
Skin	23.5 nTPM
Endometrium	21.4 nTPM
Skeletal muscle	20.6 nTPM
Prostate	14.2 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	16.3 nTPM
Skin	16.3 nTPM

Basal prostatic cells	31.2 nTPM
Prostate	31.2 nTPM

Basal respiratory cells	98.7 nTPM
Bronchus	98.7 nTPM

Cholangiocytes	20.0 nTPM
Liver	20.0 nTPM

Undifferentiated cells	22.3 nTPM
Small intestine	25.3 nTPM
Colon	21.9 nTPM
Rectum	19.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC