Single cell type - MLLT3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MLLT3
Gene descriptionⁱ Full gene name according to HGNC.	MLLT3 super elongation complex subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mucus-secreting cells - Mucin production (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes, Microglial cells, Intestinal goblet cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (HEL)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Oligodendrocytes, Astrocytes, Microglial cells, Intestinal goblet cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MLLT3 is part of cluster 27 Mucus-secreting cells - Mucin production with confidenceⁱ 1
121 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC12A8	Solute carrier family 12 member 8	0.7160	27
COG5	Component of oligomeric golgi complex 5	0.6712	8
CHRM1	Cholinergic receptor muscarinic 1	0.6526	8
SLC35A1	Solute carrier family 35 member A1	0.6398	27
SLC2A13	Solute carrier family 2 member 13	0.6154	8
SPDYE6	Speedy/RINGO cell cycle regulator family member E6	0.6001	8
ARMCX5-GPRASP2	ARMCX5-GPRASP2 readthrough	0.5951	8
SHISA9	Shisa family member 9	0.5940	8
GPR19	G protein-coupled receptor 19	0.5787	8
SPDYE11	Speedy/RINGO cell cycle regulator family member E11	0.5715	42
DPP6	Dipeptidyl peptidase like 6	0.5685	8
CBFA2T2	CBFA2/RUNX1 partner transcriptional co-repressor 2	0.5662	17
BEST2	Bestrophin 2	0.5636	27
NPR2	Natriuretic peptide receptor 2	0.5612	8
TMEM178B	Transmembrane protein 178B	0.5603	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.0 nTPM
Adipose tissue	25.0 nTPM
Breast	15.0 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	30.0 nTPM
Lung	30.0 nTPM

B-cells	8.0 nTPM
Kidney	19.0 nTPM
Breast	17.3 nTPM
Adipose tissue	8.5 nTPM
Liver	8.3 nTPM
Colon	6.4 nTPM
PBMC	5.7 nTPM
Lymph node	4.7 nTPM
Stomach	4.1 nTPM
Bone marrow	3.2 nTPM
Spleen	2.8 nTPM

Basal keratinocytes	8.3 nTPM
Skin	8.3 nTPM

Dendritic cells	17.3 nTPM
Breast	25.9 nTPM
Adipose tissue	21.9 nTPM
PBMC	4.0 nTPM

Endothelial cells	13.7 nTPM
Skeletal muscle	29.1 nTPM
Skin	28.9 nTPM
Esophagus	20.7 nTPM
Breast	20.6 nTPM
Heart muscle	18.9 nTPM
Eye	14.6 nTPM
Prostate	9.9 nTPM
Endometrium	9.4 nTPM
Lung	9.3 nTPM
Liver	9.2 nTPM
Testis	6.8 nTPM
Placenta	5.7 nTPM
Ovary	5.1 nTPM
Pancreas	3.9 nTPM

Fibroblasts	18.0 nTPM
Placenta	46.3 nTPM
Esophagus	21.9 nTPM
Prostate	19.0 nTPM
Skin	18.8 nTPM
Adipose tissue	18.0 nTPM
Skeletal muscle	17.3 nTPM
Ovary	13.9 nTPM
Stomach	13.4 nTPM
Breast	12.0 nTPM
Heart muscle	11.1 nTPM
Lung	6.7 nTPM

Intestinal goblet cells	112.3 nTPM
Colon	129.4 nTPM
Small intestine	105.0 nTPM
Rectum	102.6 nTPM

Macrophages	7.1 nTPM
PBMC	40.9 nTPM
Breast	9.7 nTPM
Bone marrow	8.7 nTPM
Skeletal muscle	6.0 nTPM
Adipose tissue	6.0 nTPM
Endometrium	5.8 nTPM
Spleen	5.2 nTPM
Lung	5.0 nTPM
Kidney	4.6 nTPM
Ovary	4.4 nTPM
Prostate	3.4 nTPM
Stomach	2.9 nTPM
Testis	2.3 nTPM
Esophagus	1.6 nTPM
Pancreas	0.0 nTPM

Paneth cells	23.6 nTPM
Rectum	39.8 nTPM
Colon	19.7 nTPM
Small intestine	11.3 nTPM

Plasma cells	18.2 nTPM
Esophagus	36.9 nTPM
Stomach	19.5 nTPM
Adipose tissue	15.5 nTPM
Bone marrow	13.2 nTPM
Spleen	5.9 nTPM

Respiratory ciliated cells	11.7 nTPM
Bronchus	13.1 nTPM
Lung	10.2 nTPM

Smooth muscle cells	21.6 nTPM
Bronchus	57.5 nTPM
Heart muscle	40.1 nTPM
Adipose tissue	23.1 nTPM
Skin	19.8 nTPM
Skeletal muscle	19.5 nTPM
Ovary	16.7 nTPM
Prostate	15.3 nTPM
Endometrium	14.8 nTPM
Breast	14.8 nTPM
Esophagus	9.3 nTPM
Pancreas	6.6 nTPM

T-cells	33.3 nTPM
Lymph node	54.0 nTPM
PBMC	52.6 nTPM
Colon	42.3 nTPM
Spleen	42.3 nTPM
Breast	40.5 nTPM
Endometrium	39.2 nTPM
Stomach	37.5 nTPM
Adipose tissue	37.1 nTPM
Bone marrow	34.0 nTPM
Skeletal muscle	33.4 nTPM
Prostate	28.4 nTPM
Skin	28.1 nTPM
Esophagus	26.2 nTPM
Liver	23.9 nTPM
Kidney	17.8 nTPM
Ovary	15.6 nTPM
Lung	13.6 nTPM

Astrocytes	144.6 nTPM
Brain	144.6 nTPM

Cholangiocytes	18.6 nTPM
Liver	18.6 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Cytotrophoblasts	0.9 nTPM
Placenta	0.9 nTPM

Undifferentiated cells	27.0 nTPM
Colon	33.6 nTPM
Rectum	31.2 nTPM
Small intestine	16.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC