Single cell type - MOB3A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MOB3A
Gene descriptionⁱ Full gene name according to HGNC.	MOB kinase activator 3A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Langerhans cells, monocytes, NK-cells, Kupffer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Langerhans cells, monocytes, NK-cells, Kupffer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MOB3A is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FMNL1	Formin like 1	0.6879	63
RIN3	Ras and Rab interactor 3	0.6452	63
C1orf162	Chromosome 1 open reading frame 162	0.6066	19
HLA-DQA2	Major histocompatibility complex, class II, DQ alpha 2	0.5941	41
ADAM8	ADAM metallopeptidase domain 8	0.5896	63
HAVCR2	Hepatitis A virus cellular receptor 2	0.5767	63
FGD2	FYVE, RhoGEF and PH domain containing 2	0.5725	57
CDC42SE1	CDC42 small effector 1	0.5699	24
RASSF5	Ras association domain family member 5	0.5684	41
SERPINB9	Serpin family B member 9	0.5654	41
COTL1	Coactosin like F-actin binding protein 1	0.5646	19
CPVL	Carboxypeptidase vitellogenic like	0.5554	41
EMP3	Epithelial membrane protein 3	0.5492	41
TSPAN33	Tetraspanin 33	0.5491	41
PLEK	Pleckstrin	0.5453	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.6 nTPM
Breast	10.5 nTPM
Adipose tissue	6.7 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	4.5 nTPM
Lung	4.5 nTPM

Astrocytes	8.8 nTPM
Brain	8.8 nTPM

B-cells	50.6 nTPM
Adipose tissue	92.3 nTPM
Colon	79.9 nTPM
Stomach	63.6 nTPM
PBMC	48.5 nTPM
Lymph node	46.1 nTPM
Spleen	45.4 nTPM
Liver	34.7 nTPM
Kidney	33.4 nTPM
Bone marrow	31.1 nTPM
Breast	30.7 nTPM

Dendritic cells	50.8 nTPM
Adipose tissue	87.1 nTPM
Breast	53.5 nTPM
PBMC	12.0 nTPM

Endothelial cells	11.7 nTPM
Liver	22.9 nTPM
Ovary	19.5 nTPM
Placenta	15.9 nTPM
Endometrium	13.5 nTPM
Skin	13.4 nTPM
Testis	12.8 nTPM
Prostate	12.4 nTPM
Esophagus	9.8 nTPM
Breast	9.8 nTPM
Skeletal muscle	9.2 nTPM
Pancreas	7.7 nTPM
Eye	7.3 nTPM
Lung	6.2 nTPM
Heart muscle	3.0 nTPM

Fibroblasts	12.0 nTPM
Adipose tissue	18.5 nTPM
Skin	16.1 nTPM
Skeletal muscle	16.0 nTPM
Prostate	14.6 nTPM
Placenta	14.1 nTPM
Stomach	13.4 nTPM
Breast	11.7 nTPM
Esophagus	11.6 nTPM
Ovary	10.0 nTPM
Lung	4.5 nTPM
Heart muscle	1.9 nTPM

Intestinal goblet cells	12.2 nTPM
Colon	13.6 nTPM
Rectum	11.9 nTPM
Small intestine	11.1 nTPM

Macrophages	50.1 nTPM
Adipose tissue	127.7 nTPM
Stomach	85.0 nTPM
Skeletal muscle	71.9 nTPM
Bone marrow	61.2 nTPM
Spleen	56.0 nTPM
Ovary	52.7 nTPM
Kidney	50.6 nTPM
Pancreas	40.8 nTPM
Prostate	37.9 nTPM
Endometrium	37.9 nTPM
Testis	36.6 nTPM
Esophagus	33.1 nTPM
Lung	25.2 nTPM
Breast	21.7 nTPM
PBMC	13.6 nTPM

Paneth cells	12.6 nTPM
Small intestine	18.8 nTPM
Colon	9.9 nTPM
Rectum	9.1 nTPM

Plasma cells	38.0 nTPM
Adipose tissue	100.7 nTPM
Stomach	44.3 nTPM
Esophagus	24.6 nTPM
Spleen	13.9 nTPM
Bone marrow	6.6 nTPM

Respiratory ciliated cells	10.1 nTPM
Bronchus	11.4 nTPM
Lung	8.7 nTPM

Smooth muscle cells	11.2 nTPM
Pancreas	19.8 nTPM
Prostate	13.4 nTPM
Skin	12.9 nTPM
Breast	12.8 nTPM
Esophagus	12.4 nTPM
Skeletal muscle	11.8 nTPM
Adipose tissue	11.8 nTPM
Endometrium	9.1 nTPM
Ovary	8.2 nTPM
Heart muscle	6.5 nTPM
Bronchus	4.8 nTPM

T-cells	37.3 nTPM
Skin	68.6 nTPM
Liver	60.4 nTPM
PBMC	52.4 nTPM
Skeletal muscle	44.3 nTPM
Colon	43.2 nTPM
Endometrium	42.4 nTPM
Adipose tissue	41.9 nTPM
Kidney	41.1 nTPM
Spleen	36.2 nTPM
Bone marrow	35.5 nTPM
Prostate	28.4 nTPM
Stomach	26.9 nTPM
Breast	26.8 nTPM
Lymph node	25.3 nTPM
Ovary	22.3 nTPM
Esophagus	19.7 nTPM
Lung	18.2 nTPM

Basal keratinocytes	15.0 nTPM
Skin	15.0 nTPM

Basal prostatic cells	10.9 nTPM
Prostate	10.9 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Undifferentiated cells	9.5 nTPM
Colon	12.3 nTPM
Small intestine	8.4 nTPM
Rectum	7.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC