Single cell type - TOMM20 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TOMM20
Gene descriptionⁱ Full gene name according to HGNC.	Translocase of outer mitochondrial membrane 20
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TOMM20 is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RPL13	Ribosomal protein L13	0.7389	32
RPS24	Ribosomal protein S24	0.7341	32
NACA	Nascent polypeptide associated complex subunit alpha	0.7336	32
RPL37	Ribosomal protein L37	0.6950	32
RPL24	Ribosomal protein L24	0.6940	32
RPS3A	Ribosomal protein S3A	0.6931	32
RPL14	Ribosomal protein L14	0.6777	32
RPL9	Ribosomal protein L9	0.6726	32
RPS7	Ribosomal protein S7	0.6721	32
RPL5	Ribosomal protein L5	0.6676	32
RPL32	Ribosomal protein L32	0.6578	32
RPL37A	Ribosomal protein L37a	0.6514	32
RPL19	Ribosomal protein L19	0.6436	32
RPS23	Ribosomal protein S23	0.6432	32
RPL7A	Ribosomal protein L7a	0.6417	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	167.2 nTPM
Breast	181.9 nTPM
Adipose tissue	152.4 nTPM

Alveolar cells type 1	137.8 nTPM
Lung	137.8 nTPM

Alveolar cells type 2	163.5 nTPM
Lung	163.5 nTPM

Astrocytes	25.1 nTPM
Brain	25.1 nTPM

B-cells	201.9 nTPM
Adipose tissue	336.4 nTPM
PBMC	244.1 nTPM
Breast	226.1 nTPM
Colon	210.8 nTPM
Liver	201.9 nTPM
Lymph node	182.8 nTPM
Spleen	181.7 nTPM
Stomach	180.3 nTPM
Kidney	128.5 nTPM
Bone marrow	126.7 nTPM

Basal squamous epithelial cells	251.6 nTPM
Esophagus	251.6 nTPM

Dendritic cells	195.5 nTPM
PBMC	211.2 nTPM
Adipose tissue	206.6 nTPM
Breast	168.8 nTPM

Endothelial cells	156.8 nTPM
Prostate	255.0 nTPM
Pancreas	204.6 nTPM
Testis	184.3 nTPM
Breast	175.6 nTPM
Endometrium	168.2 nTPM
Liver	164.2 nTPM
Skin	152.7 nTPM
Eye	145.7 nTPM
Ovary	144.3 nTPM
Esophagus	142.7 nTPM
Lung	140.4 nTPM
Skeletal muscle	131.8 nTPM
Placenta	130.1 nTPM
Heart muscle	56.1 nTPM

Enteroendocrine cells	160.5 nTPM
Colon	170.5 nTPM
Rectum	150.5 nTPM

Erythroid cells	127.0 nTPM
Bone marrow	190.0 nTPM
Liver	64.0 nTPM

Fibroblasts	139.9 nTPM
Prostate	238.7 nTPM
Adipose tissue	188.3 nTPM
Lung	167.5 nTPM
Ovary	144.1 nTPM
Breast	140.9 nTPM
Placenta	131.4 nTPM
Skin	124.1 nTPM
Skeletal muscle	116.2 nTPM
Esophagus	114.5 nTPM
Heart muscle	90.1 nTPM
Stomach	83.2 nTPM

Intestinal goblet cells	273.4 nTPM
Colon	337.4 nTPM
Rectum	280.2 nTPM
Small intestine	202.7 nTPM

Macrophages	175.7 nTPM
Adipose tissue	304.2 nTPM
Ovary	275.7 nTPM
Testis	259.2 nTPM
Endometrium	209.8 nTPM
Prostate	208.6 nTPM
Breast	188.8 nTPM
Spleen	163.8 nTPM
Kidney	158.1 nTPM
Skeletal muscle	156.3 nTPM
Lung	151.5 nTPM
Bone marrow	141.2 nTPM
Stomach	134.8 nTPM
Pancreas	130.2 nTPM
Esophagus	125.9 nTPM
PBMC	27.3 nTPM

Paneth cells	172.3 nTPM
Rectum	268.7 nTPM
Small intestine	142.7 nTPM
Colon	105.4 nTPM

Plasma cells	176.7 nTPM
Esophagus	209.4 nTPM
Spleen	192.5 nTPM
Stomach	168.2 nTPM
Adipose tissue	165.1 nTPM
Bone marrow	148.3 nTPM

Cholangiocytes	160.2 nTPM
Liver	160.2 nTPM

Collecting duct cells	49.7 nTPM
Kidney	49.7 nTPM

Cone photoreceptor cells	29.2 nTPM
Eye	29.2 nTPM

Cytotrophoblasts	171.3 nTPM
Placenta	171.3 nTPM

Respiratory ciliated cells	99.7 nTPM
Lung	107.8 nTPM
Bronchus	91.6 nTPM

Smooth muscle cells	207.5 nTPM
Bronchus	438.6 nTPM
Breast	239.9 nTPM
Prostate	230.4 nTPM
Adipose tissue	224.6 nTPM
Endometrium	194.3 nTPM
Ovary	193.6 nTPM
Skin	186.3 nTPM
Pancreas	181.7 nTPM
Skeletal muscle	150.5 nTPM
Esophagus	133.4 nTPM
Heart muscle	109.5 nTPM

T-cells	179.5 nTPM
Adipose tissue	323.6 nTPM
PBMC	298.8 nTPM
Breast	232.6 nTPM
Lymph node	224.7 nTPM
Skin	214.6 nTPM
Colon	198.1 nTPM
Ovary	186.9 nTPM
Skeletal muscle	174.4 nTPM
Endometrium	167.8 nTPM
Spleen	161.6 nTPM
Prostate	161.0 nTPM
Stomach	146.3 nTPM
Liver	131.6 nTPM
Kidney	117.1 nTPM
Bone marrow	115.7 nTPM
Lung	110.8 nTPM
Esophagus	85.2 nTPM

Undifferentiated cells	272.6 nTPM
Colon	281.4 nTPM
Rectum	281.0 nTPM
Small intestine	255.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC