Single cell type - DPY19L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DPY19L1
Gene descriptionⁱ Full gene name according to HGNC.	Dpy-19 like C-mannosyltransferase 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Early spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Excitatory neurons, Oligodendrocytes, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Excitatory neurons, Oligodendrocytes, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DPY19L1 is part of cluster 29 Early spermatids - Spermatogenesis with confidenceⁱ 1
337 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NPIPB4	Nuclear pore complex interacting protein family member B4	0.6984	29
HDAC4	Histone deacetylase 4	0.6952	21
RGS21	Regulator of G protein signaling 21	0.6807	29
TECTA	Tectorin alpha	0.6690	21
SNX31	Sorting nexin 31	0.6537	29
KBTBD12	Kelch repeat and BTB domain containing 12	0.6446	29
TDRD5	Tudor domain containing 5	0.6225	29
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	0.6204	29
ELAVL4	ELAV like RNA binding protein 4	0.5910	21
TCF20	Transcription factor 20	0.5802	29
OR1F1	Olfactory receptor family 1 subfamily F member 1	0.5758	8
SLC36A1	Solute carrier family 36 member 1	0.5750	21
ZC2HC1B	Zinc finger C2HC-type containing 1B	0.5728	8
ERCC8	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	0.5702	29
FANCC	FA complementation group C	0.5698	29

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.1 nTPM
Adipose tissue	13.4 nTPM
Breast	10.8 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	16.4 nTPM
Lung	16.4 nTPM

Astrocytes	42.7 nTPM
Brain	42.7 nTPM

B-cells	3.9 nTPM
Adipose tissue	9.0 nTPM
Breast	6.6 nTPM
Liver	5.9 nTPM
Kidney	4.8 nTPM
PBMC	4.3 nTPM
Spleen	3.5 nTPM
Lymph node	2.4 nTPM
Bone marrow	1.7 nTPM
Stomach	0.5 nTPM
Colon	0.0 nTPM

Dendritic cells	10.2 nTPM
Adipose tissue	15.0 nTPM
PBMC	8.0 nTPM
Breast	7.6 nTPM

Endothelial cells	13.9 nTPM
Endometrium	28.8 nTPM
Ovary	20.2 nTPM
Testis	19.3 nTPM
Placenta	17.0 nTPM
Esophagus	16.5 nTPM
Pancreas	15.5 nTPM
Skeletal muscle	14.8 nTPM
Liver	12.8 nTPM
Heart muscle	12.7 nTPM
Eye	10.5 nTPM
Prostate	9.9 nTPM
Skin	9.0 nTPM
Breast	7.4 nTPM
Lung	0.0 nTPM

Fibroblasts	11.3 nTPM
Heart muscle	23.0 nTPM
Adipose tissue	14.3 nTPM
Skeletal muscle	13.9 nTPM
Ovary	12.6 nTPM
Lung	10.1 nTPM
Placenta	9.1 nTPM
Stomach	8.9 nTPM
Skin	8.7 nTPM
Breast	8.5 nTPM
Prostate	8.2 nTPM
Esophagus	7.0 nTPM

Intestinal goblet cells	5.1 nTPM
Rectum	5.3 nTPM
Colon	5.0 nTPM
Small intestine	4.9 nTPM

Macrophages	8.0 nTPM
Spleen	13.5 nTPM
Esophagus	12.6 nTPM
Stomach	11.7 nTPM
Skeletal muscle	11.6 nTPM
Testis	11.1 nTPM
Adipose tissue	11.0 nTPM
Endometrium	10.6 nTPM
Ovary	10.4 nTPM
Bone marrow	10.0 nTPM
Breast	6.9 nTPM
Lung	6.4 nTPM
Kidney	3.8 nTPM
Prostate	1.2 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	4.5 nTPM
Rectum	7.0 nTPM
Colon	6.5 nTPM
Small intestine	0.0 nTPM

Plasma cells	8.0 nTPM
Adipose tissue	14.9 nTPM
Esophagus	12.3 nTPM
Spleen	6.2 nTPM
Bone marrow	5.0 nTPM
Stomach	1.5 nTPM

Respiratory ciliated cells	12.4 nTPM
Bronchus	13.1 nTPM
Lung	11.7 nTPM

Smooth muscle cells	8.5 nTPM
Adipose tissue	20.3 nTPM
Endometrium	15.9 nTPM
Pancreas	7.8 nTPM
Prostate	7.5 nTPM
Skeletal muscle	7.3 nTPM
Ovary	7.3 nTPM
Bronchus	6.8 nTPM
Breast	6.2 nTPM
Skin	5.9 nTPM
Esophagus	4.6 nTPM
Heart muscle	3.9 nTPM

T-cells	6.9 nTPM
Adipose tissue	19.3 nTPM
Endometrium	14.7 nTPM
Skeletal muscle	14.2 nTPM
Breast	7.9 nTPM
Liver	7.7 nTPM
Colon	7.6 nTPM
Esophagus	6.6 nTPM
Lung	6.1 nTPM
Bone marrow	5.9 nTPM
Spleen	5.0 nTPM
Prostate	4.7 nTPM
Skin	4.6 nTPM
Ovary	4.5 nTPM
Stomach	3.6 nTPM
PBMC	3.5 nTPM
Lymph node	1.4 nTPM
Kidney	0.7 nTPM

Basal keratinocytes	7.1 nTPM
Skin	7.1 nTPM

Basal prostatic cells	5.6 nTPM
Prostate	5.6 nTPM

Basal respiratory cells	4.4 nTPM
Bronchus	4.4 nTPM

Basal squamous epithelial cells	2.2 nTPM
Esophagus	2.2 nTPM

Undifferentiated cells	8.5 nTPM
Colon	11.0 nTPM
Rectum	8.4 nTPM
Small intestine	6.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC