Single cell type - PIGG - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIGG
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol glycan anchor biosynthesis class G
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PIGG is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCNL2	Cyclin L2	0.5501	52
MYSM1	Myb like, SWIRM and MPN domains 1	0.5311	52
CDK13	Cyclin dependent kinase 13	0.5222	52
DMTF1	Cyclin D binding myb like transcription factor 1	0.5023	52
ZNF708	Zinc finger protein 708	0.4985	52
ARGLU1	Arginine and glutamate rich 1	0.4942	52
PABPC1L	Poly(A) binding protein cytoplasmic 1 like	0.4838	52
SPICE1	Spindle and centriole associated protein 1	0.4599	52
DEPDC5	DEP domain containing 5, GATOR1 subcomplex subunit	0.4592	52
STRADA	STE20 related adaptor alpha	0.4518	42
GOLGA6L7	Golgin A6 family like 7	0.4500	40
LUC7L	LUC7 like	0.4461	52
ZNF701	Zinc finger protein 701	0.4458	52
SPG7	SPG7 matrix AAA peptidase subunit, paraplegin	0.4445	52
MED23	Mediator complex subunit 23	0.4400	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.4 nTPM
Adipose tissue	16.4 nTPM
Breast	12.4 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	12.6 nTPM
Lung	12.6 nTPM

Astrocytes	21.9 nTPM
Brain	21.9 nTPM

B-cells	12.6 nTPM
Bone marrow	18.0 nTPM
Lymph node	17.0 nTPM
PBMC	14.3 nTPM
Stomach	14.1 nTPM
Adipose tissue	13.0 nTPM
Spleen	11.8 nTPM
Liver	11.4 nTPM
Colon	11.2 nTPM
Breast	10.7 nTPM
Kidney	4.8 nTPM

Dendritic cells	14.8 nTPM
Adipose tissue	17.1 nTPM
PBMC	16.0 nTPM
Breast	11.3 nTPM

Endothelial cells	13.1 nTPM
Heart muscle	22.8 nTPM
Pancreas	19.3 nTPM
Eye	16.2 nTPM
Ovary	15.8 nTPM
Lung	15.6 nTPM
Endometrium	14.3 nTPM
Skeletal muscle	14.2 nTPM
Breast	12.9 nTPM
Testis	11.2 nTPM
Placenta	10.8 nTPM
Prostate	10.3 nTPM
Esophagus	7.3 nTPM
Skin	7.1 nTPM
Liver	6.4 nTPM

Fibroblasts	10.2 nTPM
Adipose tissue	14.4 nTPM
Skeletal muscle	12.7 nTPM
Esophagus	12.2 nTPM
Breast	11.3 nTPM
Lung	11.1 nTPM
Heart muscle	10.7 nTPM
Prostate	9.9 nTPM
Ovary	9.6 nTPM
Placenta	9.0 nTPM
Stomach	6.0 nTPM
Skin	5.9 nTPM

Intestinal goblet cells	8.5 nTPM
Small intestine	9.1 nTPM
Rectum	8.4 nTPM
Colon	7.8 nTPM

Macrophages	9.5 nTPM
Lung	15.7 nTPM
Breast	13.6 nTPM
Adipose tissue	13.0 nTPM
Pancreas	12.8 nTPM
Esophagus	12.6 nTPM
Ovary	12.4 nTPM
Skeletal muscle	11.2 nTPM
Testis	10.5 nTPM
Endometrium	9.6 nTPM
Bone marrow	8.7 nTPM
Spleen	8.3 nTPM
Stomach	5.9 nTPM
Kidney	5.3 nTPM
Prostate	3.4 nTPM
PBMC	0.0 nTPM

Paneth cells	12.8 nTPM
Colon	19.7 nTPM
Rectum	11.1 nTPM
Small intestine	7.5 nTPM

Plasma cells	14.9 nTPM
Esophagus	18.4 nTPM
Adipose tissue	18.1 nTPM
Stomach	17.4 nTPM
Spleen	10.7 nTPM
Bone marrow	9.9 nTPM

Respiratory ciliated cells	19.9 nTPM
Bronchus	23.8 nTPM
Lung	16.0 nTPM

Smooth muscle cells	11.5 nTPM
Heart muscle	21.1 nTPM
Esophagus	17.0 nTPM
Pancreas	16.1 nTPM
Ovary	13.9 nTPM
Adipose tissue	12.0 nTPM
Endometrium	10.3 nTPM
Skeletal muscle	9.2 nTPM
Breast	8.8 nTPM
Bronchus	7.7 nTPM
Prostate	6.5 nTPM
Skin	4.2 nTPM

T-cells	14.2 nTPM
Prostate	23.6 nTPM
Ovary	20.1 nTPM
Lung	18.2 nTPM
Spleen	18.0 nTPM
Lymph node	17.4 nTPM
Adipose tissue	17.3 nTPM
Stomach	17.1 nTPM
Breast	16.2 nTPM
Liver	14.6 nTPM
Bone marrow	13.3 nTPM
Endometrium	12.5 nTPM
Skin	11.1 nTPM
PBMC	9.6 nTPM
Colon	9.5 nTPM
Skeletal muscle	8.2 nTPM
Kidney	7.5 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	8.9 nTPM
Skin	8.9 nTPM

Basal prostatic cells	10.9 nTPM
Prostate	10.9 nTPM

Basal respiratory cells	17.7 nTPM
Bronchus	17.7 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Undifferentiated cells	9.7 nTPM
Rectum	10.7 nTPM
Small intestine	9.8 nTPM
Colon	8.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC