Single cell type - FAM131A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM131A
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 131 member A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAM131A is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCKBR	Cholecystokinin B receptor	0.6923	40
ARHGEF28	Rho guanine nucleotide exchange factor 28	0.6914	40
GRB14	Growth factor receptor bound protein 14	0.6730	40
C2CD2	C2 calcium dependent domain containing 2	0.6707	40
VPS8	VPS8 subunit of CORVET complex	0.6658	40
HUWE1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	0.6552	40
NPAP1	Nuclear pore associated protein 1	0.6429	40
NEIL1	Nei like DNA glycosylase 1	0.6422	40
TMEM150C	Transmembrane protein 150C	0.6416	40
INHA	Inhibin subunit alpha	0.6405	40
GREB1	Growth regulating estrogen receptor binding 1	0.6361	40
HSD17B1	Hydroxysteroid 17-beta dehydrogenase 1	0.6308	40
IFNA13	Interferon alpha 13	0.6241	40
ALG1L2	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2	0.6118	40
ZNF83	Zinc finger protein 83	0.6093	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	15.5 nTPM
Adipose tissue	15.5 nTPM
Breast	15.5 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	5.0 nTPM
Lung	5.0 nTPM

Astrocytes	13.7 nTPM
Brain	13.7 nTPM

B-cells	5.5 nTPM
Kidney	14.3 nTPM
Colon	11.2 nTPM
Adipose tissue	6.0 nTPM
Spleen	5.8 nTPM
Breast	5.3 nTPM
PBMC	4.3 nTPM
Liver	2.6 nTPM
Lymph node	2.4 nTPM
Stomach	1.8 nTPM
Bone marrow	0.8 nTPM

Dendritic cells	4.6 nTPM
Adipose tissue	7.9 nTPM
Breast	5.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	11.5 nTPM
Eye	17.0 nTPM
Prostate	16.0 nTPM
Ovary	15.7 nTPM
Skeletal muscle	15.2 nTPM
Testis	13.0 nTPM
Endometrium	12.7 nTPM
Breast	11.9 nTPM
Pancreas	11.6 nTPM
Skin	9.4 nTPM
Lung	9.3 nTPM
Placenta	8.6 nTPM
Liver	8.2 nTPM
Heart muscle	7.4 nTPM
Esophagus	5.2 nTPM

Fibroblasts	9.7 nTPM
Prostate	17.7 nTPM
Lung	14.5 nTPM
Breast	14.0 nTPM
Ovary	13.1 nTPM
Skeletal muscle	10.2 nTPM
Adipose tissue	8.9 nTPM
Skin	7.6 nTPM
Stomach	7.4 nTPM
Placenta	5.5 nTPM
Heart muscle	4.5 nTPM
Esophagus	3.4 nTPM

Intestinal goblet cells	7.5 nTPM
Colon	9.3 nTPM
Small intestine	7.3 nTPM
Rectum	6.1 nTPM

Macrophages	7.7 nTPM
Adipose tissue	13.3 nTPM
Breast	12.9 nTPM
Endometrium	10.3 nTPM
Pancreas	10.2 nTPM
Spleen	9.3 nTPM
Kidney	9.1 nTPM
Prostate	9.1 nTPM
Skeletal muscle	9.1 nTPM
Testis	8.1 nTPM
Ovary	8.0 nTPM
Lung	6.9 nTPM
Bone marrow	3.7 nTPM
Esophagus	3.1 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	9.6 nTPM
Rectum	11.3 nTPM
Colon	9.9 nTPM
Small intestine	7.5 nTPM

Plasma cells	2.5 nTPM
Adipose tissue	9.1 nTPM
Stomach	2.3 nTPM
Spleen	1.3 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	15.8 nTPM
Lung	17.5 nTPM
Bronchus	14.1 nTPM

Smooth muscle cells	14.4 nTPM
Ovary	23.9 nTPM
Skeletal muscle	23.6 nTPM
Skin	18.2 nTPM
Breast	18.2 nTPM
Prostate	16.6 nTPM
Adipose tissue	16.6 nTPM
Heart muscle	11.3 nTPM
Esophagus	10.9 nTPM
Endometrium	10.4 nTPM
Bronchus	5.6 nTPM
Pancreas	3.2 nTPM

T-cells	5.0 nTPM
Skin	17.1 nTPM
Ovary	8.9 nTPM
Breast	7.2 nTPM
Adipose tissue	6.7 nTPM
Endometrium	6.5 nTPM
Kidney	6.2 nTPM
Colon	5.2 nTPM
Skeletal muscle	5.2 nTPM
Prostate	4.7 nTPM
PBMC	4.4 nTPM
Spleen	3.4 nTPM
Stomach	2.9 nTPM
Liver	2.8 nTPM
Lung	1.5 nTPM
Lymph node	1.5 nTPM
Bone marrow	1.4 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	11.1 nTPM
Skin	11.1 nTPM

Basal prostatic cells	20.0 nTPM
Prostate	20.0 nTPM

Basal squamous epithelial cells	5.7 nTPM
Esophagus	5.7 nTPM

Collecting duct cells	14.7 nTPM
Kidney	14.7 nTPM

Undifferentiated cells	8.7 nTPM
Small intestine	8.9 nTPM
Colon	8.7 nTPM
Rectum	8.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC