Single cell type - CLTB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLTB
Gene descriptionⁱ Full gene name according to HGNC.	Clathrin light chain B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Pancreatic endocrine cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HBEC3-KT, MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CLTB is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C19orf33	Chromosome 19 open reading frame 33	0.8845	16
RHOC	Ras homolog family member C	0.8648	16
LAMA3	Laminin subunit alpha 3	0.8600	16
SDCBP2	Syndecan binding protein 2	0.8351	16
KPNA7	Karyopherin subunit alpha 7	0.8153	16
RHOD	Ras homolog family member D	0.8095	16
MYEOV	Myeloma overexpressed	0.7983	16
LAMC2	Laminin subunit gamma 2	0.7972	16
MUCL3	Mucin like 3	0.7953	16
S100A6	S100 calcium binding protein A6	0.7907	16
MMP1	Matrix metallopeptidase 1	0.7868	16
FAM25G	Family with sequence similarity 25 member G	0.7836	16
TFF1	Trefoil factor 1	0.7830	16
ARPC1A	Actin related protein 2/3 complex subunit 1A	0.7805	16
LYNX1-SLURP2	LYNX1-SLURP2 readthrough	0.7798	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	113.7 nTPM
Breast	148.2 nTPM
Adipose tissue	79.1 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	19.8 nTPM
Lung	19.8 nTPM

Astrocytes	8.5 nTPM
Brain	8.5 nTPM

B-cells	54.7 nTPM
Colon	81.5 nTPM
Liver	72.9 nTPM
Kidney	66.6 nTPM
Breast	61.5 nTPM
Stomach	48.6 nTPM
Spleen	46.8 nTPM
PBMC	45.7 nTPM
Lymph node	42.7 nTPM
Adipose tissue	40.7 nTPM
Bone marrow	40.0 nTPM

Basal squamous epithelial cells	180.4 nTPM
Esophagus	180.4 nTPM

Dendritic cells	82.3 nTPM
Breast	122.8 nTPM
Adipose tissue	72.4 nTPM
PBMC	51.8 nTPM

Endothelial cells	102.2 nTPM
Skin	221.0 nTPM
Prostate	186.1 nTPM
Pancreas	154.4 nTPM
Skeletal muscle	113.6 nTPM
Breast	111.3 nTPM
Ovary	97.5 nTPM
Eye	97.1 nTPM
Testis	84.7 nTPM
Esophagus	81.2 nTPM
Heart muscle	80.9 nTPM
Placenta	65.4 nTPM
Liver	64.2 nTPM
Endometrium	64.2 nTPM
Lung	9.3 nTPM

Enteroendocrine cells	151.8 nTPM
Colon	184.8 nTPM
Rectum	118.9 nTPM

Fibroblasts	136.7 nTPM
Skin	264.4 nTPM
Prostate	230.9 nTPM
Breast	165.5 nTPM
Adipose tissue	162.3 nTPM
Stomach	127.7 nTPM
Heart muscle	119.7 nTPM
Placenta	115.2 nTPM
Skeletal muscle	108.3 nTPM
Ovary	96.6 nTPM
Esophagus	95.3 nTPM
Lung	17.9 nTPM

Intestinal goblet cells	348.5 nTPM
Colon	567.5 nTPM
Small intestine	266.0 nTPM
Rectum	212.0 nTPM

Macrophages	88.4 nTPM
Pancreas	158.2 nTPM
Kidney	155.8 nTPM
Prostate	110.0 nTPM
Ovary	107.9 nTPM
Stomach	99.6 nTPM
Spleen	93.4 nTPM
Breast	88.3 nTPM
Bone marrow	85.0 nTPM
Adipose tissue	80.3 nTPM
Testis	79.0 nTPM
Endometrium	76.2 nTPM
Esophagus	73.9 nTPM
Skeletal muscle	61.8 nTPM
PBMC	40.9 nTPM
Lung	16.3 nTPM

Paneth cells	786.9 nTPM
Colon	1502.0 nTPM
Small intestine	563.2 nTPM
Rectum	295.6 nTPM

Plasma cells	76.4 nTPM
Spleen	117.1 nTPM
Esophagus	80.1 nTPM
Stomach	79.4 nTPM
Bone marrow	56.0 nTPM
Adipose tissue	49.1 nTPM

Respiratory ciliated cells	49.6 nTPM
Bronchus	88.9 nTPM
Lung	10.2 nTPM

Collecting duct cells	82.8 nTPM
Kidney	82.8 nTPM

Cone photoreceptor cells	64.6 nTPM
Eye	64.6 nTPM

Cytotrophoblasts	141.1 nTPM
Placenta	141.1 nTPM

Distal enterocytes	794.5 nTPM
Colon	926.9 nTPM
Rectum	662.1 nTPM

Smooth muscle cells	161.4 nTPM
Prostate	270.7 nTPM
Pancreas	257.6 nTPM
Skin	228.4 nTPM
Skeletal muscle	220.3 nTPM
Breast	151.3 nTPM
Bronchus	133.9 nTPM
Esophagus	133.4 nTPM
Ovary	131.9 nTPM
Heart muscle	102.5 nTPM
Adipose tissue	85.2 nTPM
Endometrium	60.4 nTPM

T-cells	81.3 nTPM
Skin	152.9 nTPM
Colon	142.1 nTPM
Kidney	108.9 nTPM
Stomach	101.9 nTPM
Breast	101.0 nTPM
Prostate	99.4 nTPM
Ovary	80.1 nTPM
Bone marrow	78.4 nTPM
Spleen	77.2 nTPM
Adipose tissue	76.5 nTPM
Liver	74.1 nTPM
PBMC	64.7 nTPM
Skeletal muscle	64.0 nTPM
Endometrium	59.2 nTPM
Lymph node	57.7 nTPM
Esophagus	32.8 nTPM
Lung	10.6 nTPM

Undifferentiated cells	289.7 nTPM
Colon	477.6 nTPM
Rectum	215.6 nTPM
Small intestine	175.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC