Single cell type - UCP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UCP2
Gene descriptionⁱ Full gene name according to HGNC.	Uncoupling protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Human disease related genes Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells, monocytes, NK-cells, Hofbauer cells, dendritic cells, Kupffer cells, Enteroendocrine cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, SK-BR-3, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells, monocytes, NK-cells, Hofbauer cells, dendritic cells, Kupffer cells, Enteroendocrine cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UCP2 is part of cluster 6 Erythroid cells - Oxygen transport with confidenceⁱ 1
151 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DCK	Deoxycytidine kinase	0.6933	6
TANGO2	Transport and golgi organization 2 homolog	0.6426	6
DBNL	Drebrin like	0.6400	3
LSP1	Lymphocyte specific protein 1	0.6312	3
IRF5	Interferon regulatory factor 5	0.6278	3
TCEANC	Transcription elongation factor A N-terminal and central domain containing	0.5972	6
TWF2	Twinfilin actin binding protein 2	0.5896	3
MYO1G	Myosin IG	0.5882	3
KLHDC7B	Kelch domain containing 7B	0.5732	3
FOXD4L1	Forkhead box D4 like 1	0.5729	3
GPSM3	G protein signaling modulator 3	0.5724	63
EPB42	Erythrocyte membrane protein band 4.2	0.5627	6
TALDO1	Transaldolase 1	0.5602	3
ST6GALNAC4	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	0.5596	6
DEFA4	Defensin alpha 4	0.5545	58

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.7 nTPM
Breast	6.2 nTPM
Adipose tissue	3.1 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	27.6 nTPM
Lung	27.6 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	287.4 nTPM
Stomach	605.9 nTPM
PBMC	461.1 nTPM
Bone marrow	376.9 nTPM
Colon	308.3 nTPM
Kidney	266.6 nTPM
Spleen	255.7 nTPM
Adipose tissue	195.4 nTPM
Liver	164.9 nTPM
Lymph node	143.0 nTPM
Breast	96.4 nTPM

Dendritic cells	404.4 nTPM
PBMC	828.8 nTPM
Adipose tissue	207.3 nTPM
Breast	177.1 nTPM

Endothelial cells	8.9 nTPM
Skin	28.7 nTPM
Lung	28.1 nTPM
Eye	20.3 nTPM
Breast	10.7 nTPM
Liver	9.2 nTPM
Esophagus	7.4 nTPM
Placenta	5.7 nTPM
Heart muscle	4.7 nTPM
Skeletal muscle	3.3 nTPM
Endometrium	3.0 nTPM
Ovary	2.2 nTPM
Testis	0.9 nTPM
Prostate	0.7 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	297.3 nTPM
Colon	298.4 nTPM
Rectum	296.1 nTPM

Erythroid cells	695.6 nTPM
Liver	1182.0 nTPM
Bone marrow	209.3 nTPM

Fibroblasts	9.9 nTPM
Placenta	22.0 nTPM
Lung	21.2 nTPM
Adipose tissue	14.0 nTPM
Stomach	11.9 nTPM
Esophagus	9.9 nTPM
Breast	9.4 nTPM
Ovary	6.7 nTPM
Skin	6.4 nTPM
Skeletal muscle	3.8 nTPM
Prostate	3.6 nTPM
Heart muscle	0.4 nTPM

Intestinal goblet cells	31.5 nTPM
Small intestine	42.4 nTPM
Rectum	35.1 nTPM
Colon	17.2 nTPM

Macrophages	232.3 nTPM
Pancreas	393.1 nTPM
Spleen	378.5 nTPM
Bone marrow	368.6 nTPM
Ovary	330.7 nTPM
Prostate	314.1 nTPM
Kidney	287.3 nTPM
Breast	203.2 nTPM
Adipose tissue	195.3 nTPM
PBMC	190.9 nTPM
Stomach	172.9 nTPM
Skeletal muscle	159.5 nTPM
Esophagus	152.6 nTPM
Endometrium	120.3 nTPM
Testis	112.7 nTPM
Lung	105.3 nTPM

Paneth cells	45.9 nTPM
Small intestine	86.3 nTPM
Rectum	41.5 nTPM
Colon	9.9 nTPM

Plasma cells	117.9 nTPM
Bone marrow	181.3 nTPM
Spleen	146.5 nTPM
Stomach	103.1 nTPM
Adipose tissue	96.8 nTPM
Esophagus	61.7 nTPM

Respiratory ciliated cells	137.6 nTPM
Bronchus	173.2 nTPM
Lung	102.0 nTPM

Basal keratinocytes	3.4 nTPM
Skin	3.4 nTPM

Basal prostatic cells	2.7 nTPM
Prostate	2.7 nTPM

Basal respiratory cells	20.2 nTPM
Bronchus	20.2 nTPM

Basal squamous epithelial cells	0.6 nTPM
Esophagus	0.6 nTPM

Smooth muscle cells	11.2 nTPM
Bronchus	58.0 nTPM
Pancreas	19.5 nTPM
Esophagus	9.3 nTPM
Breast	8.1 nTPM
Prostate	6.0 nTPM
Skin	5.9 nTPM
Adipose tissue	4.5 nTPM
Heart muscle	4.1 nTPM
Endometrium	4.1 nTPM
Ovary	2.2 nTPM
Skeletal muscle	1.6 nTPM

T-cells	189.9 nTPM
PBMC	317.6 nTPM
Liver	306.3 nTPM
Kidney	275.9 nTPM
Stomach	269.0 nTPM
Ovary	264.7 nTPM
Bone marrow	242.0 nTPM
Lung	214.1 nTPM
Adipose tissue	206.4 nTPM
Colon	187.7 nTPM
Spleen	175.8 nTPM
Skeletal muscle	168.2 nTPM
Esophagus	150.6 nTPM
Lymph node	129.7 nTPM
Skin	102.2 nTPM
Breast	88.7 nTPM
Prostate	80.4 nTPM
Endometrium	48.1 nTPM

Undifferentiated cells	21.7 nTPM
Small intestine	24.2 nTPM
Rectum	23.6 nTPM
Colon	17.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC