Single cell type - EID2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EID2
Gene descriptionⁱ Full gene name according to HGNC.	EP300 interacting inhibitor of differentiation 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EID2 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZFPM1	Zinc finger protein, FOG family member 1	0.5749	7
ZCCHC3	Zinc finger CCHC-type containing 3	0.5743	7
UBE2M	Ubiquitin conjugating enzyme E2 M	0.5601	7
MXD4	MAX dimerization protein 4	0.5510	7
USP27X	Ubiquitin specific peptidase 27 X-linked	0.5477	47
ADRB1	Adrenoceptor beta 1	0.5415	47
FOXO4	Forkhead box O4	0.5402	47
RRP36	Ribosomal RNA processing 36	0.5367	7
SPINDOC	Spindlin interactor and repressor of chromatin binding	0.5361	7
PGAP6	Post-glycosylphosphatidylinositol attachment to proteins 6	0.5122	18
RTL8B	Retrotransposon Gag like 8B	0.5114	47
PEG10	Paternally expressed 10	0.5103	47
XKR8	XK related 8	0.5101	47
PAGE4	PAGE family member 4	0.5096	47
RADX	RPA1 related single stranded DNA binding protein, X-linked	0.5092	18

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.4 nTPM
Breast	17.8 nTPM
Adipose tissue	15.0 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	9.2 nTPM
Lung	9.2 nTPM

Astrocytes	2.6 nTPM
Brain	2.6 nTPM

B-cells	7.3 nTPM
Adipose tissue	19.1 nTPM
PBMC	11.5 nTPM
Breast	10.7 nTPM
Liver	9.6 nTPM
Kidney	9.5 nTPM
Spleen	4.2 nTPM
Lymph node	3.2 nTPM
Stomach	1.8 nTPM
Bone marrow	1.7 nTPM
Colon	1.6 nTPM

Dendritic cells	14.0 nTPM
Adipose tissue	26.7 nTPM
Breast	15.3 nTPM
PBMC	0.0 nTPM

Endothelial cells	14.4 nTPM
Endometrium	27.5 nTPM
Eye	21.0 nTPM
Ovary	20.9 nTPM
Testis	17.4 nTPM
Skin	13.2 nTPM
Skeletal muscle	13.2 nTPM
Placenta	13.1 nTPM
Heart muscle	12.5 nTPM
Prostate	12.5 nTPM
Breast	11.7 nTPM
Liver	11.0 nTPM
Esophagus	10.7 nTPM
Lung	9.3 nTPM
Pancreas	7.7 nTPM

Fibroblasts	10.0 nTPM
Ovary	21.2 nTPM
Skeletal muscle	13.2 nTPM
Adipose tissue	12.4 nTPM
Breast	11.8 nTPM
Placenta	10.1 nTPM
Skin	10.1 nTPM
Prostate	9.9 nTPM
Heart muscle	7.5 nTPM
Esophagus	6.9 nTPM
Lung	4.5 nTPM
Stomach	3.0 nTPM

Intestinal goblet cells	5.3 nTPM
Rectum	7.3 nTPM
Small intestine	5.7 nTPM
Colon	2.9 nTPM

Macrophages	7.8 nTPM
Adipose tissue	15.7 nTPM
Breast	14.9 nTPM
Endometrium	14.7 nTPM
Ovary	13.1 nTPM
Bone marrow	10.0 nTPM
Skeletal muscle	9.4 nTPM
Pancreas	7.7 nTPM
Kidney	6.1 nTPM
Testis	5.2 nTPM
Esophagus	4.8 nTPM
Prostate	4.6 nTPM
Spleen	4.2 nTPM
Lung	4.1 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	7.4 nTPM
Rectum	8.2 nTPM
Small intestine	7.5 nTPM
Colon	6.5 nTPM

Plasma cells	7.2 nTPM
Adipose tissue	12.2 nTPM
Bone marrow	8.2 nTPM
Esophagus	6.1 nTPM
Stomach	4.9 nTPM
Spleen	4.8 nTPM

Respiratory ciliated cells	5.5 nTPM
Lung	7.3 nTPM
Bronchus	3.8 nTPM

Smooth muscle cells	12.7 nTPM
Ovary	26.8 nTPM
Endometrium	25.3 nTPM
Breast	18.6 nTPM
Skin	17.1 nTPM
Adipose tissue	14.9 nTPM
Pancreas	12.5 nTPM
Skeletal muscle	9.6 nTPM
Prostate	6.2 nTPM
Heart muscle	4.1 nTPM
Esophagus	3.1 nTPM
Bronchus	1.9 nTPM

T-cells	11.3 nTPM
Ovary	31.1 nTPM
Adipose tissue	30.3 nTPM
Endometrium	18.8 nTPM
Breast	13.1 nTPM
PBMC	12.8 nTPM
Skeletal muscle	10.7 nTPM
Skin	9.7 nTPM
Prostate	9.5 nTPM
Liver	9.3 nTPM
Kidney	7.5 nTPM
Colon	7.1 nTPM
Esophagus	6.6 nTPM
Lung	6.1 nTPM
Spleen	5.5 nTPM
Stomach	5.2 nTPM
Bone marrow	4.9 nTPM
Lymph node	3.6 nTPM

Basal respiratory cells	2.4 nTPM
Bronchus	2.4 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Cone photoreceptor cells	10.4 nTPM
Eye	10.4 nTPM

Endometrial stromal cells	23.3 nTPM
Endometrium	23.3 nTPM

Undifferentiated cells	7.5 nTPM
Rectum	9.6 nTPM
Small intestine	7.1 nTPM
Colon	5.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC