Single cell type - EPS8L2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EPS8L2
Gene descriptionⁱ Full gene name according to HGNC.	EPS8 like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (A-431, BEWO, CAPAN-2, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EPS8L2 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMEM184A	Transmembrane protein 184A	0.7766	53
KRTAP5-2	Keratin associated protein 5-2	0.7195	53
IL22RA1	Interleukin 22 receptor subunit alpha 1	0.7129	53
TRIM40	Tripartite motif containing 40	0.7083	53
PKP3	Plakophilin 3	0.6916	53
MYH14	Myosin heavy chain 14	0.6901	53
CGN	Cingulin	0.6898	53
AKR1B10	Aldo-keto reductase family 1 member B10	0.6759	45
CDC42BPG	CDC42 binding protein kinase gamma	0.6696	61
PTPRH	Protein tyrosine phosphatase receptor type H	0.6646	53
TRIM15	Tripartite motif containing 15	0.6565	53
PTK6	Protein tyrosine kinase 6	0.6552	53
MISP	Mitotic spindle positioning	0.6511	53
MVP	Major vault protein	0.6391	53
TP53I3	Tumor protein p53 inducible protein 3	0.6359	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1.8 nTPM
Breast	2.4 nTPM
Adipose tissue	1.2 nTPM

Alveolar cells type 1	141.1 nTPM
Lung	141.1 nTPM

Alveolar cells type 2	51.8 nTPM
Lung	51.8 nTPM

Astrocytes	3.9 nTPM
Brain	3.9 nTPM

B-cells	11.2 nTPM
Breast	26.8 nTPM
Colon	22.3 nTPM
Liver	13.1 nTPM
Stomach	11.3 nTPM
Kidney	9.5 nTPM
Bone marrow	7.4 nTPM
Spleen	7.2 nTPM
Lymph node	5.3 nTPM
Adipose tissue	5.0 nTPM
PBMC	4.3 nTPM

Dendritic cells	21.6 nTPM
PBMC	43.8 nTPM
Breast	12.8 nTPM
Adipose tissue	8.1 nTPM

Endothelial cells	4.7 nTPM
Placenta	10.8 nTPM
Esophagus	10.3 nTPM
Breast	7.9 nTPM
Endometrium	7.7 nTPM
Prostate	7.4 nTPM
Lung	6.2 nTPM
Skin	4.6 nTPM
Eye	3.3 nTPM
Testis	2.7 nTPM
Heart muscle	1.9 nTPM
Liver	1.8 nTPM
Skeletal muscle	0.5 nTPM
Ovary	0.1 nTPM
Pancreas	0.0 nTPM

Fibroblasts	11.5 nTPM
Lung	30.1 nTPM
Adipose tissue	19.2 nTPM
Breast	14.9 nTPM
Skin	14.8 nTPM
Esophagus	10.5 nTPM
Skeletal muscle	9.1 nTPM
Stomach	8.9 nTPM
Placenta	7.8 nTPM
Ovary	5.2 nTPM
Prostate	3.8 nTPM
Heart muscle	2.7 nTPM

Intestinal goblet cells	76.8 nTPM
Colon	101.5 nTPM
Rectum	74.8 nTPM
Small intestine	54.3 nTPM

Macrophages	2.7 nTPM
Endometrium	8.9 nTPM
Kidney	7.6 nTPM
Breast	6.7 nTPM
Prostate	4.6 nTPM
Lung	3.5 nTPM
Stomach	2.9 nTPM
Pancreas	2.5 nTPM
Esophagus	1.6 nTPM
Adipose tissue	1.2 nTPM
Skeletal muscle	1.1 nTPM
Ovary	0.1 nTPM
PBMC	0.0 nTPM
Testis	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	175.3 nTPM
Colon	339.2 nTPM
Small intestine	105.1 nTPM
Rectum	81.5 nTPM

Plasma cells	7.6 nTPM
Esophagus	12.3 nTPM
Adipose tissue	12.2 nTPM
Stomach	9.1 nTPM
Spleen	2.6 nTPM
Bone marrow	1.7 nTPM

Respiratory ciliated cells	60.9 nTPM
Bronchus	85.3 nTPM
Lung	36.5 nTPM

Smooth muscle cells	7.5 nTPM
Bronchus	31.7 nTPM
Esophagus	12.4 nTPM
Pancreas	10.7 nTPM
Skin	6.3 nTPM
Breast	5.5 nTPM
Prostate	5.3 nTPM
Heart muscle	4.8 nTPM
Endometrium	3.1 nTPM
Skeletal muscle	1.6 nTPM
Ovary	0.7 nTPM
Adipose tissue	0.7 nTPM

T-cells	18.6 nTPM
Skin	36.4 nTPM
Colon	35.6 nTPM
Breast	26.3 nTPM
Stomach	23.4 nTPM
Kidney	22.6 nTPM
Liver	21.7 nTPM
Endometrium	20.6 nTPM
Prostate	19.0 nTPM
Lung	18.2 nTPM
Ovary	17.8 nTPM
Bone marrow	17.6 nTPM
PBMC	17.1 nTPM
Skeletal muscle	11.9 nTPM
Spleen	11.1 nTPM
Adipose tissue	10.7 nTPM
Lymph node	6.5 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	19.8 nTPM
Skin	19.8 nTPM

Basal prostatic cells	26.2 nTPM
Prostate	26.2 nTPM

Basal respiratory cells	48.8 nTPM
Bronchus	48.8 nTPM

Cholangiocytes	57.2 nTPM
Liver	57.2 nTPM

Undifferentiated cells	77.2 nTPM
Colon	102.5 nTPM
Small intestine	67.2 nTPM
Rectum	61.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC