Single cell type - TIMM22 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TIMM22
Gene descriptionⁱ Full gene name according to HGNC.	Translocase of inner mitochondrial membrane 22
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TIMM22 is part of cluster 33 Fibroblasts - ECM organization with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMSB15B	Thymosin beta 15B	0.5638	33
C8orf58	Chromosome 8 open reading frame 58	0.5284	18
AC073610.1	Novel protein	0.5218	33
POLR2E	RNA polymerase II, I and III subunit E	0.5160	3
FBXO8	F-box protein 8	0.5151	33
CTHRC1	Collagen triple helix repeat containing 1	0.5086	33
MATR3	Matrin 3	0.5080	33
RAB38	RAB38, member RAS oncogene family	0.5055	47
ARSI	Arylsulfatase family member I	0.5049	33
MEST	Mesoderm specific transcript	0.5017	33
TRIAP1	TP53 regulated inhibitor of apoptosis 1	0.5003	47
IGF2	Insulin like growth factor 2	0.4995	33
TMEM185A	Transmembrane protein 185A	0.4951	51
PLAC1	Placenta enriched 1	0.4922	33
SDHAF2	Succinate dehydrogenase complex assembly factor 2	0.4867	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.2 nTPM
Breast	27.5 nTPM
Adipose tissue	12.9 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	15.9 nTPM
Lung	15.9 nTPM

Astrocytes	2.0 nTPM
Brain	2.0 nTPM

B-cells	21.7 nTPM
Kidney	42.9 nTPM
Colon	36.7 nTPM
Liver	29.0 nTPM
PBMC	21.4 nTPM
Stomach	20.9 nTPM
Spleen	18.0 nTPM
Breast	17.3 nTPM
Bone marrow	13.1 nTPM
Adipose tissue	9.0 nTPM
Lymph node	8.3 nTPM

Dendritic cells	16.3 nTPM
Breast	21.1 nTPM
Adipose tissue	19.9 nTPM
PBMC	8.0 nTPM

Endothelial cells	28.2 nTPM
Placenta	55.2 nTPM
Pancreas	54.0 nTPM
Ovary	42.4 nTPM
Skin	38.2 nTPM
Testis	31.2 nTPM
Endometrium	30.0 nTPM
Breast	23.9 nTPM
Eye	23.5 nTPM
Liver	22.9 nTPM
Heart muscle	21.9 nTPM
Prostate	18.1 nTPM
Skeletal muscle	16.1 nTPM
Esophagus	14.7 nTPM
Lung	3.1 nTPM

Fibroblasts	26.9 nTPM
Placenta	66.6 nTPM
Ovary	42.4 nTPM
Skin	28.2 nTPM
Breast	27.3 nTPM
Stomach	23.7 nTPM
Adipose tissue	21.4 nTPM
Skeletal muscle	19.8 nTPM
Lung	17.9 nTPM
Esophagus	17.4 nTPM
Heart muscle	16.8 nTPM
Prostate	14.8 nTPM

Intestinal goblet cells	11.9 nTPM
Colon	12.9 nTPM
Rectum	12.2 nTPM
Small intestine	10.7 nTPM

Macrophages	14.6 nTPM
PBMC	40.9 nTPM
Testis	23.2 nTPM
Pancreas	23.0 nTPM
Kidney	17.5 nTPM
Ovary	16.9 nTPM
Breast	13.8 nTPM
Bone marrow	12.5 nTPM
Prostate	10.3 nTPM
Endometrium	10.3 nTPM
Skeletal muscle	10.1 nTPM
Spleen	9.3 nTPM
Stomach	8.8 nTPM
Adipose tissue	8.2 nTPM
Esophagus	7.9 nTPM
Lung	5.9 nTPM

Paneth cells	8.6 nTPM
Rectum	15.0 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	13.2 nTPM
Spleen	23.2 nTPM
Bone marrow	19.8 nTPM
Stomach	16.7 nTPM
Adipose tissue	6.4 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	10.2 nTPM
Bronchus	16.1 nTPM
Lung	4.4 nTPM

Smooth muscle cells	21.4 nTPM
Pancreas	54.5 nTPM
Ovary	36.0 nTPM
Breast	24.4 nTPM
Skin	22.7 nTPM
Endometrium	18.7 nTPM
Esophagus	15.5 nTPM
Skeletal muscle	15.2 nTPM
Bronchus	14.0 nTPM
Heart muscle	13.0 nTPM
Prostate	12.9 nTPM
Adipose tissue	8.5 nTPM

T-cells	19.0 nTPM
Colon	36.1 nTPM
PBMC	28.4 nTPM
Skin	27.1 nTPM
Ovary	26.7 nTPM
Liver	22.6 nTPM
Bone marrow	20.2 nTPM
Stomach	19.9 nTPM
Kidney	19.8 nTPM
Esophagus	19.7 nTPM
Breast	18.8 nTPM
Adipose tissue	18.6 nTPM
Endometrium	16.4 nTPM
Lung	12.2 nTPM
Spleen	11.4 nTPM
Skeletal muscle	11.0 nTPM
Lymph node	9.9 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	43.6 nTPM
Skin	43.6 nTPM

Basal respiratory cells	31.5 nTPM
Bronchus	31.5 nTPM

Basal squamous epithelial cells	17.1 nTPM
Esophagus	17.1 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Undifferentiated cells	16.8 nTPM
Colon	17.5 nTPM
Small intestine	16.4 nTPM
Rectum	16.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC