Single cell type - ZNF518A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF518A
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 518A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZNF518A is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CSAD	Cysteine sulfinic acid decarboxylase	0.5703	52
KIAA2026	KIAA2026	0.5666	52
JRK	Jrk helix-turn-helix protein	0.5314	52
ATXN2	Ataxin 2	0.5117	52
DLL3	Delta like canonical Notch ligand 3	0.5114	20
BTBD8	BTB domain containing 8	0.5038	8
TMTC4	Transmembrane O-mannosyltransferase targeting cadherins 4	0.4996	42
KNOP1	Lysine rich nucleolar protein 1	0.4981	20
ZNF662	Zinc finger protein 662	0.4973	52
ZNF572	Zinc finger protein 572	0.4964	40
FRS3	Fibroblast growth factor receptor substrate 3	0.4885	20
L3MBTL1	L3MBTL histone methyl-lysine binding protein 1	0.4792	8
ZNF678	Zinc finger protein 678	0.4722	68
DBX2	Developing brain homeobox 2	0.4717	68
RHOXF2B	Rhox homeobox family member 2B	0.4655	20

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.1 nTPM
Adipose tissue	34.0 nTPM
Breast	28.2 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	28.2 nTPM
Lung	28.2 nTPM

Astrocytes	136.8 nTPM
Brain	136.8 nTPM

B-cells	26.1 nTPM
Kidney	38.1 nTPM
PBMC	37.1 nTPM
Colon	36.7 nTPM
Adipose tissue	32.6 nTPM
Breast	28.1 nTPM
Liver	18.6 nTPM
Stomach	18.6 nTPM
Lymph node	17.7 nTPM
Bone marrow	17.2 nTPM
Spleen	16.0 nTPM

Dendritic cells	31.6 nTPM
PBMC	35.8 nTPM
Adipose tissue	32.7 nTPM
Breast	26.3 nTPM

Endothelial cells	24.0 nTPM
Heart muscle	57.4 nTPM
Skeletal muscle	34.7 nTPM
Liver	33.9 nTPM
Endometrium	32.4 nTPM
Testis	31.4 nTPM
Placenta	29.0 nTPM
Ovary	27.8 nTPM
Breast	26.3 nTPM
Eye	18.6 nTPM
Prostate	14.1 nTPM
Lung	12.5 nTPM
Esophagus	10.3 nTPM
Pancreas	7.7 nTPM
Skin	0.0 nTPM

Fibroblasts	21.6 nTPM
Heart muscle	34.5 nTPM
Breast	34.5 nTPM
Skeletal muscle	30.3 nTPM
Adipose tissue	28.8 nTPM
Placenta	28.0 nTPM
Ovary	27.6 nTPM
Esophagus	20.0 nTPM
Stomach	16.3 nTPM
Prostate	9.1 nTPM
Lung	8.9 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	35.8 nTPM
Rectum	41.6 nTPM
Colon	32.9 nTPM
Small intestine	32.8 nTPM

Macrophages	31.3 nTPM
Lung	47.7 nTPM
Kidney	42.4 nTPM
Skeletal muscle	42.0 nTPM
Bone marrow	38.8 nTPM
Testis	38.3 nTPM
Ovary	38.3 nTPM
Adipose tissue	35.8 nTPM
Spleen	34.2 nTPM
Breast	33.8 nTPM
Prostate	29.8 nTPM
Endometrium	29.0 nTPM
Stomach	20.5 nTPM
Esophagus	20.4 nTPM
Pancreas	17.8 nTPM
PBMC	0.0 nTPM

Paneth cells	52.4 nTPM
Colon	65.8 nTPM
Small intestine	48.8 nTPM
Rectum	42.4 nTPM

Plasma cells	18.3 nTPM
Adipose tissue	34.2 nTPM
Esophagus	18.4 nTPM
Bone marrow	18.2 nTPM
Stomach	11.3 nTPM
Spleen	9.4 nTPM

Respiratory ciliated cells	10.2 nTPM
Lung	20.4 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	23.2 nTPM
Heart muscle	53.5 nTPM
Adipose tissue	38.7 nTPM
Endometrium	33.9 nTPM
Skeletal muscle	29.4 nTPM
Ovary	25.6 nTPM
Breast	25.0 nTPM
Prostate	18.1 nTPM
Esophagus	17.0 nTPM
Pancreas	14.2 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	23.3 nTPM
PBMC	45.2 nTPM
Liver	33.5 nTPM
Skeletal muscle	32.6 nTPM
Colon	32.3 nTPM
Endometrium	30.1 nTPM
Kidney	29.4 nTPM
Prostate	28.4 nTPM
Lung	25.8 nTPM
Breast	25.0 nTPM
Adipose tissue	24.9 nTPM
Ovary	24.5 nTPM
Bone marrow	16.8 nTPM
Stomach	15.6 nTPM
Spleen	13.2 nTPM
Lymph node	12.0 nTPM
Esophagus	6.6 nTPM
Skin	0.0 nTPM

Basal prostatic cells	17.1 nTPM
Prostate	17.1 nTPM

Basal squamous epithelial cells	13.1 nTPM
Esophagus	13.1 nTPM

Cholangiocytes	30.0 nTPM
Liver	30.0 nTPM

Collecting duct cells	40.5 nTPM
Kidney	40.5 nTPM

Undifferentiated cells	35.2 nTPM
Colon	37.9 nTPM
Rectum	34.6 nTPM
Small intestine	33.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC