Single cell type - ARL6IP6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARL6IP6
Gene descriptionⁱ Full gene name according to HGNC.	ADP ribosylation factor like GTPase 6 interacting protein 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (basophil, eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ARL6IP6 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RPIA	Ribose 5-phosphate isomerase A	0.6806	47
RAB38	RAB38, member RAS oncogene family	0.6683	47
MAB21L4	Mab-21 like 4	0.6413	47
SHISA5	Shisa family member 5	0.6357	47
GPR143	G protein-coupled receptor 143	0.6347	47
AC091959.1	Novel readthrough transcript	0.6273	38
SNRNP40	Small nuclear ribonucleoprotein U5 subunit 40	0.6180	12
RMI2	RecQ mediated genome instability 2	0.6018	47
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.6013	47
CBY2	Chibby family member 2	0.5987	47
IL36RN	Interleukin 36 receptor antagonist	0.5966	47
ATP6V1B1	ATPase H+ transporting V1 subunit B1	0.5946	47
DYNC2I2	Dynein 2 intermediate chain 2	0.5925	38
XKR8	XK related 8	0.5914	47
MTARC1	Mitochondrial amidoxime reducing component 1	0.5876	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.3 nTPM
Adipose tissue	43.0 nTPM
Breast	25.7 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	10.0 nTPM
Lung	10.0 nTPM

Astrocytes	30.7 nTPM
Brain	30.7 nTPM

B-cells	41.9 nTPM
Stomach	54.5 nTPM
Lymph node	52.5 nTPM
Spleen	51.9 nTPM
Bone marrow	51.5 nTPM
PBMC	38.6 nTPM
Kidney	38.1 nTPM
Liver	38.0 nTPM
Colon	36.7 nTPM
Adipose tissue	34.5 nTPM
Breast	22.8 nTPM

Dendritic cells	42.4 nTPM
PBMC	67.8 nTPM
Breast	32.4 nTPM
Adipose tissue	27.1 nTPM

Endothelial cells	31.3 nTPM
Pancreas	50.2 nTPM
Skin	48.9 nTPM
Liver	45.8 nTPM
Placenta	43.8 nTPM
Breast	31.8 nTPM
Skeletal muscle	31.6 nTPM
Ovary	30.5 nTPM
Testis	29.6 nTPM
Esophagus	28.4 nTPM
Prostate	26.7 nTPM
Lung	24.9 nTPM
Endometrium	18.0 nTPM
Eye	15.4 nTPM
Heart muscle	12.3 nTPM

Fibroblasts	27.9 nTPM
Placenta	72.4 nTPM
Skin	43.2 nTPM
Adipose tissue	28.8 nTPM
Esophagus	25.6 nTPM
Ovary	24.7 nTPM
Breast	24.4 nTPM
Stomach	22.3 nTPM
Prostate	20.6 nTPM
Skeletal muscle	18.2 nTPM
Heart muscle	13.4 nTPM
Lung	13.4 nTPM

Intestinal goblet cells	22.2 nTPM
Rectum	26.2 nTPM
Small intestine	22.4 nTPM
Colon	17.9 nTPM

Macrophages	33.6 nTPM
PBMC	122.7 nTPM
Kidney	43.2 nTPM
Testis	40.1 nTPM
Adipose tissue	33.4 nTPM
Esophagus	29.9 nTPM
Lung	29.2 nTPM
Spleen	27.9 nTPM
Bone marrow	27.5 nTPM
Stomach	26.4 nTPM
Prostate	26.3 nTPM
Breast	22.9 nTPM
Ovary	21.2 nTPM
Skeletal muscle	20.7 nTPM
Endometrium	17.5 nTPM
Pancreas	15.3 nTPM

Paneth cells	18.6 nTPM
Rectum	27.2 nTPM
Small intestine	18.8 nTPM
Colon	9.9 nTPM

Plasma cells	33.8 nTPM
Esophagus	43.0 nTPM
Bone marrow	37.9 nTPM
Spleen	36.3 nTPM
Stomach	32.3 nTPM
Adipose tissue	19.4 nTPM

Respiratory ciliated cells	29.2 nTPM
Bronchus	39.5 nTPM
Lung	19.0 nTPM

Smooth muscle cells	24.9 nTPM
Ovary	38.0 nTPM
Skin	37.3 nTPM
Pancreas	30.2 nTPM
Adipose tissue	27.8 nTPM
Heart muscle	23.2 nTPM
Skeletal muscle	21.4 nTPM
Bronchus	20.9 nTPM
Endometrium	19.9 nTPM
Esophagus	18.6 nTPM
Prostate	18.5 nTPM
Breast	18.0 nTPM

T-cells	45.2 nTPM
Skin	71.3 nTPM
Stomach	67.6 nTPM
Kidney	64.3 nTPM
Spleen	64.3 nTPM
Ovary	60.1 nTPM
Bone marrow	57.0 nTPM
Lymph node	51.6 nTPM
Colon	49.0 nTPM
Adipose tissue	44.3 nTPM
Breast	41.8 nTPM
Liver	38.6 nTPM
Lung	33.4 nTPM
Skeletal muscle	32.1 nTPM
PBMC	28.9 nTPM
Prostate	23.6 nTPM
Endometrium	21.3 nTPM
Esophagus	19.7 nTPM

Basal keratinocytes	106.6 nTPM
Skin	106.6 nTPM

Basal prostatic cells	48.5 nTPM
Prostate	48.5 nTPM

Basal respiratory cells	74.0 nTPM
Bronchus	74.0 nTPM

Basal squamous epithelial cells	50.7 nTPM
Esophagus	50.7 nTPM

Undifferentiated cells	24.5 nTPM
Small intestine	28.2 nTPM
Rectum	25.5 nTPM
Colon	20.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC