Single cell type - STAP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STAP2
Gene descriptionⁱ Full gene name according to HGNC.	Signal transducing adaptor family member 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Enterocytes - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Paneth cells, Distal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (NK-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (A-431, HaCaT, MCF7, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Paneth cells, Distal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

STAP2 is part of cluster 45 Enterocytes - Digestion with confidenceⁱ 1
268 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CBLC	Cbl proto-oncogene C	0.7932	53
TMEM45B	Transmembrane protein 45B	0.7303	53
SDCBP2	Syndecan binding protein 2	0.7193	16
MALL	Mal, T cell differentiation protein like	0.7067	53
UGT1A8	UDP glucuronosyltransferase family 1 member A8	0.7062	26
PPP1R14D	Protein phosphatase 1 regulatory inhibitor subunit 14D	0.6966	53
TMIGD1	Transmembrane and immunoglobulin domain containing 1	0.6963	45
B3GNT8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	0.6943	45
CLDN7	Claudin 7	0.6942	53
C11orf86	Chromosome 11 open reading frame 86	0.6938	45
SLC51B	Solute carrier family 51 subunit beta	0.6923	45
TSPAN8	Tetraspanin 8	0.6752	45
SULT1A2	Sulfotransferase family 1A member 2	0.6747	45
LGALS3BP	Galectin 3 binding protein	0.6725	53
ETHE1	ETHE1 persulfide dioxygenase	0.6723	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	6.7 nTPM
Breast	8.4 nTPM
Adipose tissue	5.0 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	14.4 nTPM
Lung	14.4 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	2.4 nTPM
Colon	9.6 nTPM
Kidney	4.8 nTPM
Liver	4.1 nTPM
Breast	4.0 nTPM
Stomach	0.9 nTPM
Spleen	0.7 nTPM
Lymph node	0.2 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Bone marrow	0.0 nTPM

Dendritic cells	2.3 nTPM
PBMC	4.0 nTPM
Breast	2.5 nTPM
Adipose tissue	0.4 nTPM

Endothelial cells	10.1 nTPM
Pancreas	23.1 nTPM
Ovary	21.8 nTPM
Skin	14.6 nTPM
Prostate	13.7 nTPM
Breast	12.4 nTPM
Esophagus	10.2 nTPM
Lung	9.3 nTPM
Testis	8.0 nTPM
Placenta	7.3 nTPM
Endometrium	5.9 nTPM
Heart muscle	5.5 nTPM
Liver	3.7 nTPM
Skeletal muscle	3.4 nTPM
Eye	2.4 nTPM

Fibroblasts	4.5 nTPM
Prostate	9.5 nTPM
Ovary	8.9 nTPM
Esophagus	6.1 nTPM
Breast	5.7 nTPM
Heart muscle	5.6 nTPM
Skin	5.5 nTPM
Placenta	2.5 nTPM
Adipose tissue	2.4 nTPM
Skeletal muscle	1.6 nTPM
Lung	1.2 nTPM
Stomach	0.0 nTPM

Intestinal goblet cells	147.5 nTPM
Colon	167.2 nTPM
Small intestine	142.0 nTPM
Rectum	133.4 nTPM

Macrophages	1.8 nTPM
Kidney	8.3 nTPM
Stomach	2.9 nTPM
Breast	2.6 nTPM
Pancreas	2.5 nTPM
Prostate	2.2 nTPM
Lung	2.1 nTPM
Ovary	1.8 nTPM
Endometrium	1.7 nTPM
Spleen	1.0 nTPM
Skeletal muscle	0.8 nTPM
Testis	0.6 nTPM
Adipose tissue	0.3 nTPM
PBMC	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	343.4 nTPM
Colon	418.4 nTPM
Rectum	311.5 nTPM
Small intestine	300.4 nTPM

Plasma cells	1.4 nTPM
Bone marrow	3.3 nTPM
Stomach	1.5 nTPM
Adipose tissue	1.3 nTPM
Spleen	0.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	44.9 nTPM
Bronchus	73.8 nTPM
Lung	16.0 nTPM

Smooth muscle cells	7.9 nTPM
Bronchus	44.9 nTPM
Esophagus	7.8 nTPM
Prostate	6.9 nTPM
Ovary	5.7 nTPM
Breast	5.4 nTPM
Pancreas	4.7 nTPM
Skin	3.5 nTPM
Heart muscle	3.0 nTPM
Adipose tissue	2.1 nTPM
Endometrium	2.0 nTPM
Skeletal muscle	1.4 nTPM

T-cells	3.3 nTPM
Colon	10.5 nTPM
Kidney	9.6 nTPM
Prostate	9.5 nTPM
Liver	4.7 nTPM
Breast	3.4 nTPM
Stomach	3.2 nTPM
Endometrium	2.9 nTPM
Skin	2.8 nTPM
Ovary	2.2 nTPM
PBMC	2.1 nTPM
Lymph node	1.3 nTPM
Spleen	1.3 nTPM
Bone marrow	0.8 nTPM
Skeletal muscle	0.5 nTPM
Adipose tissue	0.4 nTPM
Lung	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	40.5 nTPM
Skin	40.5 nTPM

Basal prostatic cells	59.8 nTPM
Prostate	59.8 nTPM

Basal respiratory cells	171.4 nTPM
Bronchus	171.4 nTPM

Basal squamous epithelial cells	42.7 nTPM
Esophagus	42.7 nTPM

Undifferentiated cells	173.2 nTPM
Colon	216.0 nTPM
Rectum	160.4 nTPM
Small intestine	143.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC