Single cell type - TSHZ2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TSHZ2
Gene descriptionⁱ Full gene name according to HGNC.	Teashirt zinc finger homeobox 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells, Leydig cells, Theca cells, Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (naive CD4 T-cell, T-reg)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (AN3-CA, ASC diff, HeLa, SiHa, U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells, Leydig cells, Theca cells, Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TSHZ2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF83	Zinc finger protein 83	0.6173	52
OR52H1	Olfactory receptor family 52 subfamily H member 1	0.6146	52
FOXL2NB	FOXL2 neighbor	0.5917	40
MAP3K15	Mitogen-activated protein kinase kinase kinase 15	0.5883	52
ZNF630	Zinc finger protein 630	0.5835	52
ARMH4	Armadillo like helical domain containing 4	0.5792	52
LRP8	LDL receptor related protein 8	0.5762	40
VPS8	VPS8 subunit of CORVET complex	0.5747	40
ZC3H7B	Zinc finger CCCH-type containing 7B	0.5718	52
TAS2R20	Taste 2 receptor member 20	0.5654	52
HSPG2	Heparan sulfate proteoglycan 2	0.5651	40
SCUBE1	Signal peptide, CUB domain and EGF like domain containing 1	0.5648	40
CCDC194	Coiled-coil domain containing 194	0.5608	52
TMEM150C	Transmembrane protein 150C	0.5598	40
IFNA13	Interferon alpha 13	0.5587	40

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	171.4 nTPM
Adipose tissue	194.1 nTPM
Breast	148.7 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.6 nTPM
Lung	0.6 nTPM

Astrocytes	32.7 nTPM
Brain	32.7 nTPM

B-cells	7.0 nTPM
PBMC	20.0 nTPM
Breast	13.4 nTPM
Adipose tissue	8.1 nTPM
Colon	6.4 nTPM
Liver	6.4 nTPM
Lymph node	4.5 nTPM
Bone marrow	4.1 nTPM
Stomach	3.7 nTPM
Spleen	3.5 nTPM
Kidney	0.0 nTPM

Dendritic cells	1.3 nTPM
Breast	3.6 nTPM
Adipose tissue	0.3 nTPM
PBMC	0.0 nTPM

Endothelial cells	125.7 nTPM
Skin	354.7 nTPM
Esophagus	333.1 nTPM
Liver	294.4 nTPM
Breast	199.3 nTPM
Prostate	126.3 nTPM
Skeletal muscle	125.7 nTPM
Placenta	100.6 nTPM
Lung	71.7 nTPM
Endometrium	56.0 nTPM
Testis	35.0 nTPM
Heart muscle	27.0 nTPM
Eye	17.0 nTPM
Ovary	15.3 nTPM
Pancreas	3.9 nTPM

Fibroblasts	93.3 nTPM
Adipose tissue	206.6 nTPM
Breast	140.1 nTPM
Ovary	135.8 nTPM
Skeletal muscle	131.0 nTPM
Esophagus	98.5 nTPM
Prostate	92.8 nTPM
Skin	77.9 nTPM
Stomach	75.7 nTPM
Heart muscle	36.8 nTPM
Lung	21.2 nTPM
Placenta	9.7 nTPM

Intestinal goblet cells	1.9 nTPM
Small intestine	4.3 nTPM
Colon	0.7 nTPM
Rectum	0.6 nTPM

Macrophages	2.8 nTPM
Testis	8.8 nTPM
Endometrium	7.9 nTPM
Skeletal muscle	6.8 nTPM
Esophagus	6.3 nTPM
Breast	5.5 nTPM
Ovary	4.1 nTPM
Lung	1.2 nTPM
Adipose tissue	0.9 nTPM
Kidney	0.8 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	2.7 nTPM
Small intestine	7.5 nTPM
Rectum	0.6 nTPM
Colon	0.0 nTPM

Plasma cells	16.0 nTPM
Esophagus	43.0 nTPM
Stomach	14.3 nTPM
Bone marrow	11.5 nTPM
Adipose tissue	9.1 nTPM
Spleen	2.2 nTPM

Respiratory ciliated cells	19.9 nTPM
Bronchus	34.0 nTPM
Lung	5.8 nTPM

Smooth muscle cells	48.2 nTPM
Ovary	191.9 nTPM
Adipose tissue	140.8 nTPM
Skeletal muscle	57.2 nTPM
Endometrium	54.4 nTPM
Breast	28.3 nTPM
Pancreas	15.1 nTPM
Skin	14.7 nTPM
Bronchus	11.2 nTPM
Prostate	8.8 nTPM
Heart muscle	8.2 nTPM
Esophagus	0.0 nTPM

T-cells	24.2 nTPM
PBMC	85.1 nTPM
Lymph node	65.5 nTPM
Skin	46.5 nTPM
Kidney	44.5 nTPM
Colon	25.2 nTPM
Skeletal muscle	22.6 nTPM
Spleen	22.2 nTPM
Breast	15.2 nTPM
Adipose tissue	12.4 nTPM
Lung	12.2 nTPM
Endometrium	11.8 nTPM
Bone marrow	11.6 nTPM
Stomach	11.1 nTPM
Prostate	9.5 nTPM
Ovary	6.7 nTPM
Esophagus	6.6 nTPM
Liver	3.3 nTPM

Basal keratinocytes	45.4 nTPM
Skin	45.4 nTPM

Basal respiratory cells	43.8 nTPM
Bronchus	43.8 nTPM

Basal squamous epithelial cells	37.0 nTPM
Esophagus	37.0 nTPM

Cholangiocytes	54.3 nTPM
Liver	54.3 nTPM

Undifferentiated cells	2.6 nTPM
Small intestine	6.4 nTPM
Colon	1.0 nTPM
Rectum	0.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC