Single cell type - FES - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FES
Gene descriptionⁱ Full gene name according to HGNC.	FES proto-oncogene, tyrosine kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, monocytes, Macrophages, Hofbauer cells, Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HEL, HL-60, HMC-1, NB-4, THP-1, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells, monocytes, Macrophages, Hofbauer cells, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FES is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PPP1R2B	PPP1R2 family member B	0.7773	10
ACTBL2	Actin beta like 2	0.7766	10
SMIM35	Small integral membrane protein 35	0.7506	10
PF4V1	Platelet factor 4 variant 1	0.7467	10
ETV3L	ETS variant transcription factor 3 like	0.7163	10
SNX6	Sorting nexin 6	0.7087	10
POTEE	POTE ankyrin domain family member E	0.6900	10
HNRNPCL2	Heterogeneous nuclear ribonucleoprotein C like 2	0.6846	10
RNF130	Ring finger protein 130	0.6827	10
LTC4S	Leukotriene C4 synthase	0.6652	10
CYFIP1	Cytoplasmic FMR1 interacting protein 1	0.6630	10
CLTA	Clathrin light chain A	0.6626	10
RAP1A	RAP1A, member of RAS oncogene family	0.6556	10
UBE2Q1	Ubiquitin conjugating enzyme E2 Q1	0.6547	10
NHSL2	NHS like 2	0.6467	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	5.8 nTPM
Lung	5.8 nTPM

Astrocytes	3.6 nTPM
Brain	3.6 nTPM

B-cells	5.0 nTPM
Colon	12.8 nTPM
Kidney	9.5 nTPM
PBMC	8.5 nTPM
Liver	4.2 nTPM
Breast	4.0 nTPM
Adipose tissue	2.5 nTPM
Bone marrow	2.5 nTPM
Spleen	2.4 nTPM
Lymph node	2.2 nTPM
Stomach	1.8 nTPM

Basal keratinocytes	3.8 nTPM
Skin	3.8 nTPM

Dendritic cells	25.6 nTPM
PBMC	47.8 nTPM
Adipose tissue	19.5 nTPM
Breast	9.5 nTPM

Endothelial cells	29.1 nTPM
Skeletal muscle	47.1 nTPM
Testis	34.0 nTPM
Ovary	33.5 nTPM
Heart muscle	32.9 nTPM
Esophagus	32.0 nTPM
Pancreas	30.9 nTPM
Prostate	28.9 nTPM
Placenta	27.3 nTPM
Lung	24.9 nTPM
Endometrium	24.9 nTPM
Liver	24.7 nTPM
Skin	24.3 nTPM
Breast	23.8 nTPM
Eye	18.6 nTPM

Fibroblasts	9.0 nTPM
Lung	12.3 nTPM
Adipose tissue	12.1 nTPM
Skeletal muscle	11.6 nTPM
Breast	11.4 nTPM
Esophagus	11.0 nTPM
Ovary	9.8 nTPM
Skin	8.6 nTPM
Stomach	7.4 nTPM
Placenta	6.2 nTPM
Heart muscle	5.7 nTPM
Prostate	3.1 nTPM

Intestinal goblet cells	2.0 nTPM
Rectum	3.3 nTPM
Colon	1.4 nTPM
Small intestine	1.4 nTPM

Macrophages	51.9 nTPM
Ovary	89.5 nTPM
Stomach	88.0 nTPM
Adipose tissue	76.2 nTPM
Spleen	68.5 nTPM
Bone marrow	65.0 nTPM
Skeletal muscle	59.8 nTPM
Testis	52.3 nTPM
Esophagus	44.1 nTPM
Pancreas	43.4 nTPM
Kidney	43.2 nTPM
Prostate	38.9 nTPM
Breast	37.9 nTPM
Lung	35.7 nTPM
Endometrium	35.6 nTPM
PBMC	0.0 nTPM

Paneth cells	2.0 nTPM
Rectum	6.1 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	4.0 nTPM
Adipose tissue	18.8 nTPM
Stomach	1.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	0.2 nTPM
Bronchus	0.3 nTPM
Lung	0.0 nTPM

Smooth muscle cells	12.9 nTPM
Bronchus	54.7 nTPM
Heart muscle	20.9 nTPM
Breast	13.7 nTPM
Ovary	9.8 nTPM
Skin	9.7 nTPM
Adipose tissue	8.9 nTPM
Skeletal muscle	6.6 nTPM
Endometrium	5.6 nTPM
Pancreas	4.5 nTPM
Prostate	4.1 nTPM
Esophagus	3.1 nTPM

T-cells	6.7 nTPM
Colon	17.1 nTPM
Ovary	15.6 nTPM
Prostate	14.2 nTPM
Lung	12.2 nTPM
Stomach	10.1 nTPM
Liver	6.9 nTPM
Skeletal muscle	6.2 nTPM
Endometrium	5.7 nTPM
PBMC	5.3 nTPM
Skin	4.6 nTPM
Spleen	3.9 nTPM
Bone marrow	3.8 nTPM
Kidney	3.4 nTPM
Breast	2.4 nTPM
Lymph node	1.4 nTPM
Adipose tissue	1.0 nTPM
Esophagus	0.0 nTPM

Distal enterocytes	0.6 nTPM
Rectum	0.7 nTPM
Colon	0.5 nTPM

Early spermatids	1.7 nTPM
Testis	1.7 nTPM

Excitatory neurons	2.8 nTPM
Brain	2.8 nTPM

Exocrine glandular cells	4.3 nTPM
Pancreas	4.3 nTPM

Undifferentiated cells	3.7 nTPM
Rectum	4.6 nTPM
Small intestine	3.9 nTPM
Colon	2.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC