Single cell type - CRIP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CRIP2
Gene descriptionⁱ Full gene name according to HGNC.	Cysteine rich protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Nuclear processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Endothelial cells, Adipocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (T-reg, naive B-cell, memory CD4 T-cell, memory B-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (EFO-21, MCF7, SK-BR-3, T-47d, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Endothelial cells, Adipocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CRIP2 is part of cluster 43 Cardiomyocytes - Nuclear processes with confidenceⁱ 1
192 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PEAR1	Platelet endothelial aggregation receptor 1	0.7667	48
PGM5	Phosphoglucomutase 5	0.7226	14
SMIM10	Small integral membrane protein 10	0.6799	48
SERF1B	Small EDRK-rich factor 1B	0.6434	43
DAZ2	Deleted in azoospermia 2	0.6405	43
IRAG1	Inositol 1,4,5-triphosphate receptor associated 1	0.6326	43
PPIAL4C	Peptidylprolyl isomerase A like 4C	0.6103	43
EHD2	EH domain containing 2	0.5990	48
SEPTIN4	Septin 4	0.5984	43
MCAM	Melanoma cell adhesion molecule	0.5949	48
NES	Nestin	0.5878	48
FMC1-LUC7L2	FMC1-LUC7L2 readthrough	0.5856	43
SEPTIN5	Septin 5	0.5833	43
GPR4	G protein-coupled receptor 4	0.5830	48
BMX	BMX non-receptor tyrosine kinase	0.5799	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Alveolar cells type 1	157.0 nTPM
Lung	157.0 nTPM

Alveolar cells type 2	33.7 nTPM
Lung	33.7 nTPM

Astrocytes	17.9 nTPM
Brain	17.9 nTPM

B-cells	15.0 nTPM
Adipose tissue	59.1 nTPM
Breast	30.7 nTPM
Stomach	14.5 nTPM
Bone marrow	13.1 nTPM
Spleen	7.2 nTPM
Liver	6.8 nTPM
Colon	4.8 nTPM
Kidney	4.8 nTPM
Lymph node	4.6 nTPM
PBMC	4.3 nTPM

Basal keratinocytes	153.2 nTPM
Skin	153.2 nTPM

Adipocytes	459.4 nTPM
Adipose tissue	479.6 nTPM
Breast	439.3 nTPM

Dendritic cells	8.2 nTPM
Breast	12.8 nTPM
Adipose tissue	11.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	510.4 nTPM
Esophagus	857.8 nTPM
Heart muscle	817.3 nTPM
Skin	621.0 nTPM
Ovary	604.7 nTPM
Placenta	562.7 nTPM
Breast	505.9 nTPM
Testis	478.8 nTPM
Skeletal muscle	471.4 nTPM
Pancreas	467.1 nTPM
Liver	437.5 nTPM
Lung	374.3 nTPM
Prostate	347.4 nTPM
Eye	302.6 nTPM
Endometrium	297.0 nTPM

Fibroblasts	132.9 nTPM
Heart muscle	647.7 nTPM
Stomach	201.9 nTPM
Lung	182.0 nTPM
Skin	178.7 nTPM
Skeletal muscle	58.5 nTPM
Adipose tissue	49.1 nTPM
Breast	42.4 nTPM
Placenta	39.5 nTPM
Esophagus	30.0 nTPM
Prostate	21.1 nTPM
Ovary	10.5 nTPM

Intestinal goblet cells	0.3 nTPM
Colon	0.7 nTPM
Rectum	0.1 nTPM
Small intestine	0.0 nTPM

Macrophages	9.3 nTPM
Adipose tissue	31.7 nTPM
Skeletal muscle	20.5 nTPM
Lung	17.9 nTPM
Esophagus	14.2 nTPM
Prostate	11.5 nTPM
Endometrium	9.9 nTPM
Breast	9.1 nTPM
Stomach	8.8 nTPM
Kidney	8.3 nTPM
Testis	3.5 nTPM
Pancreas	2.5 nTPM
Spleen	2.1 nTPM
Ovary	0.2 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	7.0 nTPM
Esophagus	18.4 nTPM
Adipose tissue	15.5 nTPM
Stomach	1.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	155.7 nTPM
Bronchus	196.1 nTPM
Lung	115.2 nTPM

Smooth muscle cells	339.5 nTPM
Heart muscle	1315.2 nTPM
Esophagus	586.1 nTPM
Breast	342.3 nTPM
Skeletal muscle	289.3 nTPM
Skin	282.5 nTPM
Adipose tissue	268.0 nTPM
Prostate	223.1 nTPM
Endometrium	151.0 nTPM
Pancreas	141.4 nTPM
Ovary	87.8 nTPM
Bronchus	48.1 nTPM

Cholangiocytes	107.2 nTPM
Liver	107.2 nTPM

Collecting duct cells	189.4 nTPM
Kidney	189.4 nTPM

Cone photoreceptor cells	4.2 nTPM
Eye	4.2 nTPM

Cytotrophoblasts	2.6 nTPM
Placenta	2.6 nTPM

T-cells	32.5 nTPM
Skin	177.8 nTPM
Skeletal muscle	82.3 nTPM
Adipose tissue	62.4 nTPM
Esophagus	45.9 nTPM
Kidney	39.1 nTPM
Lung	25.8 nTPM
Breast	23.5 nTPM
Spleen	18.8 nTPM
Endometrium	18.5 nTPM
Bone marrow	15.9 nTPM
PBMC	12.9 nTPM
Lymph node	10.0 nTPM
Liver	6.2 nTPM
Prostate	4.7 nTPM
Stomach	3.3 nTPM
Colon	2.9 nTPM
Ovary	2.2 nTPM

Undifferentiated cells	0.2 nTPM
Colon	0.3 nTPM
Rectum	0.2 nTPM
Small intestine	0.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC